FOXH1 and LRRC14

Data Source: HiPPIP (Novel)

		FOXH1	LRRC14
Name		forkhead box H1	leucine rich repeat containing 14
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Activin Responsive Factor Complex	Cytoplasm Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding SMAD Binding Nuclear Androgen Receptor Binding Co-SMAD Binding R-SMAD Binding DNA-binding Transcription Factor Binding	Protein Binding Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Looping Secondary Heart Field Specification Determination Of Left/right Asymmetry In Lateral Mesoderm Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Determination Of Left/right Symmetry Anterior/posterior Pattern Specification Embryonic Heart Tube Anterior/posterior Pattern Specification Aorta Morphogenesis Nodal Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Negative Regulation Of Androgen Receptor Signaling Pathway Hepatocyte Differentiation Cellular Response To Cytokine Stimulus	Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Toll-like Receptor Signaling Pathway
Pathways		Signaling by NODAL Signaling by Activin Germ layer formation at gastrulation Formation of axial mesoderm	Regulation of NF-kappa B signaling
GWAS		Blood metabolite levels ( 26401656 ) Educational attainment ( 25201988 ) General cognitive ability ( 29844566 )	Blood metabolite levels ( 26401656 ) Cognitive ability (MTAG) ( 29186694 ) Educational attainment ( 25201988 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Red cell distribution width ( 32888494 )
Novel Interactors		4 novel interactors: LRRC14 RECQL4 RPL8 SUPT20H	2 novel interactors: FOXH1 GPAA1
Interacting Genes		68 interacting genes: ACTMAP AOC1 ARID5A ATP23 ATXN1L BATF2 C10orf55 CEACAM6 CFAP68 CREBBP CRX CRYBA1 CYSRT1 DAZAP2 DRAP1 FAM168B FAM83A FOXD2 FOXG1 HDHD3 HEY1 HLX HOXA1 HSF4 KLHL26 KRTAP11-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP7-1 LASP1 MAGED1 MGAT5B MSX2 NKX2-5 NOTO OXER1 PLA2G10 PNMA5 PPP1R37 PRR20A PRR20B PRR20C PRR20D PRR20E PRR22 RBM46 RBPMS2 RNF144B SERGEF SMAD2 SMAD3 SMAD4 SOX14 SOX4 TEKT5 TFG TLX3 TSC1 UBAP2 UFSP1 ZC3H10 ZIC1 ZNF34 ZNF503	None recorded
Entrez ID		8928	9684
HPRD ID		04689	14312
Ensembl ID		ENSG00000160973	ENSG00000160959
Uniprot IDs		O75593	Q15048
PDB IDs		5XOC 7YZB	Not available
GO Terms Enriched among Interactors		Transcription Regulator Complex Embryonic Morphogenesis Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intermediate Filament Cardiac Conduction System Development DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding SMAD Protein Complex Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Heteromeric SMAD Protein Complex Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Cardiac Septum Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Regionalization Negative Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Ventricular Septum Morphogenesis I-SMAD Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Pattern Specification Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Activin Responsive Factor Complex Gastrulation Paraxial Mesoderm Morphogenesis Heart Valve Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Differentiation Embryonic Pattern Specification Cardiac Muscle Tissue Development SMAD Protein Signal Transduction Chromatin Binding Mesoderm Morphogenesis R-SMAD Binding Outflow Tract Septum Morphogenesis Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Muscle Cell Differentiation Regulation Of Gene Expression RNA Polymerase II Transcription Regulator Complex Tube Morphogenesis	GPI-anchor Transamidase Activity GPI-anchor Transamidase Complex Maintenance Of Protein Localization In Endoplasmic Reticulum Attachment Of GPI Anchor To Protein GPI Anchor Binding GPI Anchored Protein Biosynthesis Protein Retention In ER Lumen Axial Mesoderm Development Activin Responsive Factor Complex Embryonic Heart Tube Anterior/posterior Pattern Specification Nodal Signaling Pathway Cardiac Right Ventricle Morphogenesis Determination Of Left/right Asymmetry In Lateral Mesoderm Ventricular Trabecula Myocardium Morphogenesis Co-SMAD Binding Hepatocyte Differentiation Heart Field Specification Secondary Heart Field Specification Specification Of Animal Organ Identity Negative Regulation Of Androgen Receptor Signaling Pathway GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Nuclear Androgen Receptor Binding Heart Trabecula Morphogenesis Aorta Morphogenesis Activin Receptor Signaling Pathway BHLH Transcription Factor Binding Cardiac Ventricle Morphogenesis R-SMAD Binding Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Maintenance Of Protein Localization In Organelle Ventricular Cardiac Muscle Tissue Morphogenesis SMAD Binding Maintenance Of Protein Location In Cell Mesoderm Development Cardiac Muscle Tissue Morphogenesis Maintenance Of Protein Location Artery Morphogenesis Outflow Tract Morphogenesis Heart Looping Glycolipid Biosynthetic Process Embryonic Heart Tube Morphogenesis Maintenance Of Location In Cell Muscle Tissue Morphogenesis Maintenance Of Location Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cis-regulatory Region Sequence-specific DNA Binding Glycolipid Metabolic Process Determination Of Bilateral Symmetry