NKX2-5 and TRIP10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NKX2-5	TRIP10
Description		NK2 homeobox 5	thyroid hormone receptor interactor 10
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Protein-containing Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex Nkx-2.5 Complex	Phagocytic Cup Nucleoplasm Cytoplasm Lysosome Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Cortex Membrane Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Atrioventricular Node Development Bundle Of His Development Purkinje Myocyte Differentiation Aortic Valve Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Ventricle Formation Right Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Atrial Cardiac Muscle Tissue Development Apoptotic Process Involved In Heart Morphogenesis Septum Secundum Development Proepicardium Development Pulmonary Myocardium Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Heart Development Adult Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Sodium Ion Transport Negative Regulation Of Myotube Differentiation Hemopoiesis Cell Differentiation Epithelial Cell Differentiation Thyroid Gland Development Embryonic Heart Tube Development Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Heart Contraction Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Cardiac Muscle Tissue Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cardioblast Differentiation Ventricular Cardiac Myofibril Assembly Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Pharyngeal System Development Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Heart Contraction Cardiac Muscle Contraction Positive Regulation Of Transcription Initiation By RNA Polymerase II Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Atrioventricular Node Cell Development Atrioventricular Node Cell Fate Commitment Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cardiac Conduction Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process	Endocytosis Cell Communication Signal Transduction Actin Cytoskeleton Organization
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Cardiogenesis Cardiogenesis	Clathrin-mediated endocytosis RHOQ GTPase cycle
Drugs
Diseases		Tetralogy of Fallot Congenital nongoitrous hypothyroidism (CHNG) Atrial septal defect
GWAS		Atrial fibrillation ( 29892015 30061737) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate ( 23583979) Infantile hypertrophic pyloric stenosis ( 22306654) PR interval ( 20062060 30046033 32439900) Resting heart rate ( 27798624) Stroke ( 26089329) TPE interval (resting) ( 32386560)
Interacting Genes		19 interacting genes: CAMTA2 CSNK2A1 FBXO25 FOXH1 GATA4 HDAC1 HIPK1 HIPK2 JARID2 KDM6A KPNA4 KRTAP8-1 RBPMS SHOX SRF TBX2 TBX5 TLE1 TRIP10	43 interacting genes: ABI1 ABL2 AKAP9 ARHGAP12 ARHGAP17 CDC42 CREBBP CTNNB1 DNM2 DTX3 HOXC11 HTT JRK LYN MEOX1 MEOX2 NKX2-5 PAX6 PDE6G POT1 PRKACA RHOJ RHOQ RIN1 RXRA SF3A2 SH3BP1 SHANK3 SMARCE1 SMURF1 SRC STAT3 TERF1 THAP1 THRB TINF2 UTF1 WAS WASF1 WASL WBP11 WWP2 ZBTB7B
Entrez ID		1482	9322
HPRD ID		02787	05142
Ensembl ID		ENSG00000183072	ENSG00000125733
Uniprot IDs		A0A0S2Z383 A0A0S2Z3K2 E5RH49 P52952	Q15642 W4VSQ9
PDB IDs		3RKQ 4S0H 6WC2 6WC5	2CT4 2EFK 2KE4
Enriched GO Terms of Interacting Partners?		Embryonic Morphogenesis DNA-binding Transcription Factor Binding Cardiocyte Differentiation Sequence-specific DNA Binding Embryonic Camera-type Eye Morphogenesis Heart Looping Nucleoplasm Embryonic Heart Tube Morphogenesis Chromatin Nucleus Anatomical Structure Morphogenesis Anatomical Structure Formation Involved In Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Aorta Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Blood Vessel Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Heart Tube Anterior/posterior Pattern Specification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Positive Regulation Of Biosynthetic Process Epithelial Tube Morphogenesis Muscle Cell Differentiation Transcription Regulator Complex Lens Induction In Camera-type Eye Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Histone Deacetylase Binding Positive Regulation Of Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Macromolecule Biosynthetic Process Tube Morphogenesis Animal Organ Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Muscle Tissue Development Embryonic Retina Morphogenesis In Camera-type Eye Morphogenesis Of An Epithelium Anterior/posterior Pattern Specification Iris Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Eye Morphogenesis Positive Regulation Of Cell Population Proliferation	Positive Regulation Of Cellular Component Organization Actin Filament Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Supramolecular Fiber Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Organelle Organization SH3 Domain Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Cell Projection Organization Shelterin Complex Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Signal Transduction Regulation Of Cell Projection Organization Transcription By RNA Polymerase II Actin Filament-based Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Transmembrane Transporter Binding Nuclear Telomere Cap Complex Developmental Process Regulation Of Actin Cytoskeleton Organization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Telomere Maintenance Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Primary Metabolic Process Telomere Capping Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Positive Regulation Of Signal Transduction Establishment Of Organelle Localization Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cytoskeleton Organization Membrane Invagination Ectoderm Development Regulation Of Cell Communication Regulation Of Signaling Cell Projection Morphogenesis Positive Regulation Of DNA Metabolic Process Intracellular Signaling Cassette
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