FOXH1 and FOXG1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (in vivo, in vitro)

		FOXH1	FOXG1
Gene Name		forkhead box H1	forkhead box G1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Activin Responsive Factor Complex	Nucleus
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Transcription Cofactor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Enhancer Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding SMAD Binding Androgen Receptor Binding Co-SMAD Binding R-SMAD Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Heart Looping Secondary Heart Field Specification Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Embryonic Heart Tube Anterior/posterior Pattern Specification Aorta Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Axial Mesoderm Development Negative Regulation Of Androgen Receptor Signaling Pathway Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Negative Regulation Of Androgen Receptor Activity	Transcription, DNA-templated Brain Development Aging Negative Regulation Of Transcription, DNA-templated
Pathways		Signaling by Activin Signaling by NODAL
Drugs
Diseases
GWAS			Longevity ( 20834067) Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		6 interactors: DRAP1 FOXG1 NKX2-5 SMAD2 SMAD3 SMAD4	16 interactors: APOE EEF1G FOXH1 FOXO1 FOXO3 FOXO4 GDF9 HDAC1 HES1 KDM5B SMAD1 SMAD2 SMAD3 SMAD4 TLE1 TLE3
Entrez ID		8928	2290
HPRD ID		04689	01283
Ensembl ID		ENSG00000160973	ENSG00000176165
Uniprot IDs		O75593	P55316
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stem Cell Differentiation SMAD Protein Complex Assembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Mesenchyme Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Endoderm Development Primary MiRNA Processing Embryonic Pattern Specification Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Tube Morphogenesis Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Regulation Of Transforming Growth Factor Beta2 Production Paraxial Mesoderm Morphogenesis Pattern Specification Process Mesonephros Development Growth Positive Regulation Of Cell Development Heart Development Transforming Growth Factor Beta Receptor Signaling Pathway Mesoderm Development Kidney Epithelium Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Nodal Signaling Pathway RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Embryonic Morphogenesis Embryonic Foregut Morphogenesis Tissue Morphogenesis Response To Transforming Growth Factor Beta Foregut Morphogenesis Gastrulation Regulation Of Cellular Response To Growth Factor Stimulus Paraxial Mesoderm Development Gene Expression Tube Development Production Of MiRNAs Involved In Gene Silencing By MiRNA	Cellular Response To Growth Factor Stimulus Response To Growth Factor Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Cellular Macromolecule Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Macromolecule Biosynthetic Process Response To Transforming Growth Factor Beta Transcription, DNA-templated Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway RNA Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Proliferation Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter Primary MiRNA Processing Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Differentiation Mesonephros Development Organ Development Mesoderm Development Anatomical Structure Development Cardiovascular System Development
Tagcloud ?		alphav antiangiogenic beta3 bioactivities dextran dishes epas1 epc epcs erg exponentially floating fosl1 gata1 hey1 hhex hif1a icam1 id1 medicines mmp9 nfkb1 r1 smad1 tie2 transductions vasculogenesis vcam1 ve	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Difference) ?		alphav antiangiogenic beta3 bioactivities dextran dishes epas1 epc epcs erg exponentially floating fosl1 gata1 hey1 hhex hif1a icam1 id1 medicines mmp9 nfkb1 r1 smad1 tie2 transductions vasculogenesis vcam1 ve	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Intersection) ?