FOXH1 and SUPT20H

		FOXH1	SUPT20H
Description		forkhead box H1	SPT20 homolog, SAGA complex component
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GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Activin Responsive Factor Complex	SAGA Complex Nucleus SAGA-type Complex
	Molecular Function	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding SMAD Binding Nuclear Androgen Receptor Binding Co-SMAD Binding R-SMAD Binding DNA-binding Transcription Factor Binding	Transcription Coregulator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Looping Secondary Heart Field Specification Determination Of Left/right Asymmetry In Lateral Mesoderm Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Determination Of Left/right Symmetry Anterior/posterior Pattern Specification Embryonic Heart Tube Anterior/posterior Pattern Specification Aorta Morphogenesis Nodal Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Negative Regulation Of Androgen Receptor Signaling Pathway Hepatocyte Differentiation Cellular Response To Cytokine Stimulus	Regulation Of DNA Repair Regulation Of Transcription By RNA Polymerase II Autophagy Gastrulation Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription
Pathways		Signaling by NODAL Signaling by Activin Germ layer formation at gastrulation Formation of axial mesoderm	HATs acetylate histones
Drugs
Diseases
GWAS		Blood metabolite levels ( 26401656) Educational attainment ( 25201988) General cognitive ability ( 29844566)	Platelet distribution width ( 32888494)
Interacting Genes		68 interacting genes: ACTMAP AOC1 ARID5A ATP23 ATXN1L BATF2 C10orf55 CEACAM6 CFAP68 CREBBP CRX CRYBA1 CYSRT1 DAZAP2 DRAP1 FAM168B FAM83A FOXD2 FOXG1 HDHD3 HEY1 HLX HOXA1 HSF4 KLHL26 KRTAP11-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP7-1 LASP1 MAGED1 MGAT5B MSX2 NKX2-5 NOTO OXER1 PLA2G10 PNMA5 PPP1R37 PRR20A PRR20B PRR20C PRR20D PRR20E PRR22 RBM46 RBPMS2 RNF144B SERGEF SMAD2 SMAD3 SMAD4 SOX14 SOX4 TEKT5 TFG TLX3 TSC1 UBAP2 UFSP1 ZC3H10 ZIC1 ZNF34 ZNF503	10 interacting genes: AQP2 ATXN1 AURKA H3-4 LCOR MAP3K7 MAPK1 MAPK14 STAT3 UBQLN4
Entrez ID		8928	55578
HPRD ID		04689	10135
Ensembl ID		ENSG00000160973	ENSG00000102710
Uniprot IDs		O75593	A8K8L1 Q8NEM7 R4GND2
PDB IDs		5XOC 7YZB	7KTR 7KTS 8H7G
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Embryonic Morphogenesis Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intermediate Filament Cardiac Conduction System Development DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding SMAD Protein Complex Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Heteromeric SMAD Protein Complex Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Cardiac Septum Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Regionalization Negative Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Ventricular Septum Morphogenesis I-SMAD Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Pattern Specification Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Activin Responsive Factor Complex Gastrulation Paraxial Mesoderm Morphogenesis Heart Valve Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Differentiation Embryonic Pattern Specification Cardiac Muscle Tissue Development SMAD Protein Signal Transduction Chromatin Binding Mesoderm Morphogenesis R-SMAD Binding Outflow Tract Septum Morphogenesis Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Muscle Cell Differentiation Regulation Of Gene Expression RNA Polymerase II Transcription Regulator Complex Tube Morphogenesis	MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Cytokine Stimulus Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Peptide Response To Cytokine Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Tumor Necrosis Factor Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Metabolic Process Protein Serine Kinase Activity Response To Tumor Necrosis Factor Phosphorylation Protein Serine/threonine Kinase Activity Cytokine-mediated Signaling Pathway P38MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Astrocyte Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway DNA-binding Transcription Factor Binding Insulin-like Growth Factor Receptor Signaling Pathway Protein Kinase Activity Positive Regulation Of Erythrocyte Differentiation Lipopolysaccharide-mediated Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Biological Quality Carbohydrate Transmembrane Transport Regulation Of Primary Metabolic Process MAPK Cascade Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Nucleus Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Locomotion Carbohydrate Transport Kinase Activity Regulation Of Erythrocyte Differentiation Canonical NF-kappaB Signal Transduction Nucleoplasm Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Transcription By RNA Polymerase II Regulation Of Signal Transduction Response To Growth Factor
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