CWF19L2 and TRIM37

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CWF19L2	TRIM37
Gene Name		CWF19-like 2, cell cycle control (S. pombe)	tripartite motif containing 37
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Cytoplasm Peroxisome Cytosol Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Catalytic Activity	Chromatin Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of NF-kappaB Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of Centriole Replication Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Aggresome Assembly
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		27 interactors: APP BRCA1 CALCOCO1 CALCOCO2 CARD9 CCDC136 CCDC57 FAM9B HOOK2 KRT40 LHX9 LZTS2 MAD1L1 MEOX1 MTUS2 NAB2 NDEL1 RINT1 SF3B4 STX11 TAX1BP1 TP53BP2 TRIM27 TRIM37 TRIM54 TRIM9 VIM	59 interactors: ANKRD11 APEX2 APTX ARNT2 BYSL CCDC33 CDC20B CDK5RAP2 COPB1 CWF19L2 DDX6 DLGAP5 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RPL9 SCNM1 SSX2IP TANK TCEB3B TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZMAT2 ZNF329 ZNF417 ZNF655
Entrez ID		143884	4591
HPRD ID		13102	05463
Ensembl ID		ENSG00000152404	ENSG00000108395
Uniprot IDs		Q2TBE0	A8K0V9 A8K8U4 F8WEE6 O94972
PDB IDs			3LRQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Centriole Replication Intracellular Receptor Signaling Pathway Regulation Of Centriole Replication Regulation Of Cell Cycle Process Innate Immune Response Negative Regulation Of Centrosome Duplication Regulation Of Organelle Organization Regulation Of Cell Cycle Regulation Of Cellular Component Organization Regulation Of Transcription From RNA Polymerase III Promoter Establishment Of Localization In Cell Intracellular Transport Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cellular Process Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule-based Process Microtubule-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Negative Regulation Of Cell Cycle Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Centrosome Duplication Protein Autoubiquitination Establishment Of Vesicle Localization Immune Response Cellular Localization Vesicle Localization Regulation Of Centrosome Cycle Axon Cargo Transport Centrosome Cycle Cell Cycle Defense Response Gonad Morphogenesis Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Regulation Of Metaphase Plate Congression Regulation Of Cytoskeleton Organization Secretion By Cell Organelle Organization Synaptic Vesicle Exocytosis Regulation Of Cytokine Production Vesicle-mediated Transport Cellular Process Apoptotic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Protein Ubiquitination Regulation Of Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Gene Expression	Protein Polyubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Innate Immune Response Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K63-linked Ubiquitination Cellular Response To Stress Catabolic Process Polynucleotide 3' Dephosphorylation Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA-templated Transcription In Response To Stress Programmed Cell Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Regulation Of Cell Cycle Phase Transition Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cell Death Death Activation Of NF-kappaB-inducing Kinase Activity Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Cellular Protein Catabolic Process DNA Repair Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Stress-activated MAPK Cascade NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of Metabolic Process
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