CWF19L2 and AXIN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CWF19L2	AXIN2
Description		CWF19 like cell cycle control factor 2	axin 2
Image
GO Annotations	Cellular Component	Nucleoplasm Post-mRNA Release Spliceosomal Complex	Nucleus Cytoplasm Centrosome Cytosol Plasma Membrane Beta-catenin Destruction Complex Protein-containing Complex
	Molecular Function	Protein Binding	Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Molecular Adaptor Activity I-SMAD Binding
	Biological Process	MRNA Splicing, Via Spliceosome	Osteoblast Differentiation Somitogenesis Intramembranous Ossification Secondary Heart Field Specification Aortic Valve Morphogenesis Mitral Valve Morphogenesis Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Intracellular Protein Localization Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Dorsal/ventral Axis Specification Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Bone Mineralization Regulation Of Mismatch Repair Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Osteoblast Proliferation Negative Regulation Of Osteoblast Proliferation Odontogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Maintenance Of DNA Repeat Elements Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation MRNA Stabilization Cell Development Response To Steroid Hormone Canonical Wnt Signaling Pathway Regulation Of Chondrocyte Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Dexamethasone Stimulus Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Extracellular Matrix Organization
Pathways		mRNA Splicing - Major Pathway	TCF dependent signaling in response to WNT Binding of TCF/LEF:CTNNB1 to target gene promoters Degradation of AXIN Ub-specific processing proteases
Drugs
Diseases			Oligodontia-colorectal cancer syndrome Tooth agenesis; Hypodontia
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Coronary artery disease ( 29212778) Cortex volume ( 31530798) Diastolic blood pressure ( 27841878) Fourth ventricle volume ( 31530798) Parkinson's disease progression (cognitive) ( 33111402) Pars opercularis volume ( 31530798) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)	Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Refractive error ( 32231278)
Interacting Genes		80 interacting genes: ABLIM3 APP AXIN2 BACH2 BRCA1 CALCOCO1 CALCOCO2 CARD10 CARD9 CCDC102B CCDC136 CCDC57 CCDC88B CEP63 CEP70 CEP76 CFAP53 CNTROB CWF19L1 DES DISC1 DRC4 EXOC8 FAM9B FCHO1 FSD2 FXR1 FXR2 GFAP GOLGA2 GOLGA6L9 GRIPAP1 HOMER3 HOOK1 HOOK2 HSF2BP IKBKG IKZF1 KANK2 KASH5 KIF24 KIFC3 KRT40 LHX3 LHX9 LIMS1 LMNA LZTS1 LZTS2 M1AP MAD1L1 MEOX1 MTUS2 NAB2 NDEL1 PDE4DIP PIBF1 PICK1 PSTPIP1 RINT1 SF3B4 SNW1 STX11 TAX1BP1 TBC1D1 TFIP11 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM37 TRIM54 TRIM9 VIM VPS52 ZBTB8A ZMYND12 ZNF35 ZNF655 ZRANB1	56 interacting genes: AMOT ANKRD6 AP1M1 APC APC2 BARD1 BTRC BYSL C2orf68 CAPN7 CCDC112 CHIC2 CSNK1E CTAG2 CTNNB1 CWF19L2 ELOA FAM161A FBP1 FBP2 FXR1 FXR2 GSK3B HEMGN HOXB5 KCNK12 KIFC3 KRTAP10-10 KRTAP10-8 KRTAP4-5 KRTAP9-2 LNX1 MCRS1 PPP2R5A PRDX1 PSMB2 RANGAP1 SCNM1 SIAH1 SMAD1 SMAD3 SMAD7 SNCA STX11 TCEA2 TCEANC TGFB1 TOP3B TSGA10 TXLNA TXLNB ZNF124 ZNF189 ZNF417 ZNF587 ZNF648
Entrez ID		143884	8313
HPRD ID		13102	04935
Ensembl ID		ENSG00000152404	ENSG00000168646
Uniprot IDs		Q2TBE0	B7ZKL5 E7ES00 Q9Y2T1
PDB IDs		6ID0 6ID1 8RO2	8HEO
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytoskeleton Microtubule-based Process Identical Protein Binding Microtubule Cytoskeleton Organization Organelle Organization Cytoskeleton Organization Centrosome Protein Binding Microtubule Binding Microtubule Organizing Center Microtubule Supramolecular Fiber Organization Microtubule Organizing Center Organization Perinuclear Region Of Cytoplasm Organelle Assembly Cellular Component Assembly Centriole Intracellular Transport Cytosol Cellular Localization Establishment Of Localization In Cell Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Protein Domain Specific Binding Regulation Of Cellular Component Organization Regulation Of Organelle Organization Positive Regulation Of Gene Expression Plasma Membrane Bounded Cell Projection Organization Centriole Replication Regulation Of Centriole Replication Nuclear Pore Localization CBM Complex FHF Complex Regulation Of Long-term Neuronal Synaptic Plasticity Glial Cell Development Negative Regulation Of Cell Cycle Cytoplasmic Microtubule Organization Cilium Assembly Dynein Light Intermediate Chain Binding Negative Regulation Of Cell Cycle Process Membraneless Organelle Assembly Radial Glia-guided Pyramidal Neuron Migration Regulation Of Autophagy Microtubule Nucleation Centriole Assembly Regulation Of Synaptic Plasticity Intermediate Filament Organization	Beta-catenin Destruction Complex Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Binding Regulation Of Wnt Signaling Pathway I-SMAD Binding Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Cell-cell Junction Organization Heteromeric SMAD Protein Complex Regulation Of Cartilage Development Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signalosome Centrosome Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Ureteric Bud Development Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nucleus Cell Junction Organization Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway Mesonephric Epithelium Development Mesonephric Tubule Development Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Protein Localization Cellular Response To Growth Factor Stimulus Regulation Of Epithelial To Mesenchymal Transition Regulation Of Nucleocytoplasmic Transport Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process SMAD Protein Signal Transduction Positive Regulation Of Catabolic Process Response To Growth Factor Regulation Of Long-term Neuronal Synaptic Plasticity Kidney Epithelium Development Catenin Complex Regulation Of Intracellular Protein Transport Regulation Of Osteoblast Differentiation Identical Protein Binding Protein Binding Positive Regulation Of Cartilage Development Regulation Of Protein Localization To Nucleus Protein Catabolic Process Positive Regulation Of Protein Localization To Centrosome SMAD Protein Complex Regulation Of Protein Export From Nucleus
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?