ZSCAN20 and ZKSCAN4

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ZSCAN20	ZKSCAN4
Description		zinc finger and SCAN domain containing 20	zinc finger with KRAB and SCAN domains 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways			Generic Transcription Pathway
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 29403010) Neuropathic pain in type 2 diabetes ( 26629533) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)	Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278) Schizophrenia ( 30285260) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: CRYAA RIPK3 SCAND1 ZKSCAN4	19 interacting genes: CABP5 IL36RN LXN MAP1LC3A MDM4 MEOX2 OGT OSGIN1 PSMA6 TIAM1 TRIM39 ZKSCAN7 ZNF397 ZNF483 ZNF496 ZSCAN20 ZSCAN22 ZSCAN30 ZSCAN32
Entrez ID		7579	387032
HPRD ID		15769	15768
Ensembl ID		ENSG00000121903	ENSG00000187626
Uniprot IDs		P17040	A0A0S2Z658 B7Z7H3 Q969J2
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Hydrogen Peroxide Response To Reactive Oxygen Species Identical Protein Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway T Cell Differentiation Execution Phase Of Necroptosis Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Tubulin Complex Assembly Regulation Of Macromolecule Biosynthetic Process Lens Fiber Cell Morphogenesis Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Gamma-delta T Cell Activation Peptidyl-tyrosine Autophosphorylation CD8 Receptor Binding Phospholipase Activator Activity CD4 Receptor Binding CD27 Signaling Pathway Gamma-delta T Cell Differentiation Lymphocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Protein Antigen Binding T Cell Activation Necroptotic Signaling Pathway Regulation Of Activation-induced Cell Death Of T Cells Positive Regulation Of Necroptotic Process Positive Regulation Of Programmed Necrotic Cell Death Response To UV-A Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Receptor Binding Mononuclear Cell Differentiation Response To Oxidative Stress Embryonic Camera-type Eye Morphogenesis Lens Morphogenesis In Camera-type Eye Necroptotic Process Regulation Of Apoptotic Process Regulation Of Metabolic Process Leukocyte Differentiation Phosphatidylinositol 3-kinase Binding Regulation Of Apoptotic Signaling Pathway Regulation Of T Cell Activation Regulation Of Programmed Cell Death Positive Regulation Of T Cell Receptor Signaling Pathway Lymph Node Development Structural Constituent Of Eye Lens Gamma-delta T Cell Activation Phospholipase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Zinc Ion Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Protein Catabolic Process Metal Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Purine Ribonucleoside Triphosphate Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Primary Metabolic Process Mitophagy Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process
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