QRICH1 and IP6K2

		QRICH1	IP6K2
Description		glutamine rich 1	inositol hexakisphosphate kinase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cell Junction
	Molecular Function	DNA Binding Protein Binding	Nucleotide Binding Inositol-1,3,4,5,6-pentakisphosphate Kinase Activity Inositol Hexakisphosphate Kinase Activity Diphosphoinositol Pentakisphosphate Kinase Activity Inositol Hexakisphosphate 5-kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Inositol 5-diphosphate Pentakisphosphate 5-kinase Activity Diphosphoinositol Tetrakisphosphate Kinase Activity Flavonoid Binding
	Biological Process	Response To Unfolded Protein Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Integrated Stress Response Signaling	Lipid Metabolic Process Negative Regulation Of Cell Growth Inositol Phosphate Biosynthetic Process Positive Regulation Of Apoptotic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Phosphate Biosynthetic Process Protein Stabilization Organophosphate Biosynthetic Process Cellular Response To Flavonoid
Pathways			Synthesis of IPs in the nucleus Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Femur bone mineral density x serum urate levels interaction ( 34046847) General factor of neuroticism ( 30867560) Inflammatory bowel disease ( 28067908) Refractive error ( 32231278) Resting heart rate ( 27798624) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)	Adult body size ( 32376654) Age at first birth ( 34211149) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diastolic blood pressure ( 27841878) Eosinophil count ( 32888494) Experiencing mood swings ( 29500382) Feeling fed-up ( 29500382) General cognitive ability ( 29844566) HDL cholesterol ( 30275531) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 23128233 28067908) Lipoprotein (a) levels ( 33730874) Morning person ( 30696823) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		55 interacting genes: ACTL9 ACTMAP ARID5A ATF7IP ATXN1 BICRAL CEACAM6 CIMIP2B CRX CRYAA CYSRT1 DNAAF6 DSCR9 FHL2 FHL3 FHL5 GMCL1 HIVEP1 HSFY1 HSPB8 KHDC4 KLHDC7B LASP1 LBX1 LHX3 LHX4 LMO3 LMO4 MEOX1 MYH7B NFIX NFYA NLK PAX6 PIERCE2 POGZ POU6F2 PRKAR1B PUF60 RBM17 SELENOV SEPHS1 SIAH1 SMAP1 SP2 SRARP TEKT5 TOX4 TRAF1 TRAF2 USP54 YPEL3 ZDHHC17 ZMAT1 ZYX	7 interacting genes: HSP90AA1 LNX2 MEOX2 PLOD3 PLSCR1 RBPMS ZBTB2
Entrez ID		54870	51447
HPRD ID		13372	07380
Ensembl ID		ENSG00000198218	ENSG00000068745
Uniprot IDs		A1L3Z9 Q2TAL8	B2RCP4 C9JRM0 Q9UHH9
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin Medial Motor Column Neuron Differentiation Cell Differentiation In Spinal Cord Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of RNA Metabolic Process Motor Neuron Axon Guidance Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Transcription Regulator Complex DNA Binding Spinal Cord Motor Neuron Cell Fate Specification DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Nucleobase-containing Compound Metabolic Process Thioesterase Binding Spinal Cord Association Neuron Differentiation HMG Box Domain Binding	Response To Unfolded Protein Rho GDP-dissociation Inhibitor Binding CTP Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process DATP Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Phosphatidylserine Biosynthetic Process Mercury Ion Binding Lead Ion Binding Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Hydroxylysine Biosynthetic Process Procollagen Glucosyltransferase Activity Procollagen-lysine 5-dioxygenase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Basement Membrane Assembly Procollagen Galactosyltransferase Activity MRNA CDS Binding
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