SULF1

Name	sulfatase 1
Structure	No pdb structure
Interactors	5 interactors: APP CRYAA DSCR9 DYRK1A NEDD4
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Apparatus Golgi Stack Plasma Membrane Cell Surface Extracellular Matrix Membrane Raft
	Molecular Function	Arylsulfatase Activity Calcium Ion Binding Glycosaminoglycan Binding N-acetylglucosamine-6-sulfatase Activity Sulfuric Ester Hydrolase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Kidney Development Negative Regulation Of Endothelial Cell Proliferation Chondrocyte Development Glomerular Filtration Apoptotic Process Positive Regulation Of Vascular Endothelial Growth Factor Production Esophagus Smooth Muscle Contraction Negative Regulation Of Angiogenesis Positive Regulation Of Wnt Signaling Pathway Heparan Sulfate Proteoglycan Metabolic Process Negative Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Glomerular Basement Membrane Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Embryonic Skeletal System Development Cartilage Development Bone Development Innervation Negative Regulation Of Prostatic Bud Formation
GWAS	Cervical cancer ( 28806749 ) Crohn's disease ( 32581322 ) Dupuytren's disease ( 21732829 ) Evening vs. morning chronotype (sMEQ score) ( 32579418 ) Fasting blood insulin (BMI interaction) ( 22581228 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Height ( 21998595 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Thyroid stimulating hormone levels ( 30367059 32769997 )
Entrez ID	23213
HPRD ID	15450
Ensembl ID	ENSG00000137573
Uniprot IDs	Q8IWU6
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Response To Light Stimulus Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Radiation Histone H3T45 Kinase Activity Formation Of Structure Involved In A Symbiotic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Spontaneous Synaptic Transmission Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Catabolic Process Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endothelin Production Negative Regulation Of Macromolecule Biosynthetic Process Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Protein-containing Complex Negative Regulation Of Biosynthetic Process Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Response To UV Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Channel Inhibitor Activity Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Beta-2 Adrenergic Receptor Binding