TTC39B and VAPB

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)

		TTC39B	VAPB
Description		tetratricopeptide repeat domain 39B	VAMP associated protein B and C
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Endoplasmic Reticulum Exit Site Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Cadherin Binding Protein Heterodimerization Activity Beta-tubulin Binding
	Biological Process	Lipid Metabolic Process Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Cholesterol Homeostasis Regulation Of Cholesterol Metabolic Process	Intracellular Calcium Ion Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Response To Unfolded Protein Endoplasmic Reticulum Organization Viral Release From Host Cell Cholesterol Transport Endoplasmic Reticulum Unfolded Protein Response IRE1-mediated Unfolded Protein Response Suppression Of Viral Release By Host Host-mediated Suppression Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral RNA Genome Replication Positive Regulation Of Viral Genome Replication Negative Regulation By Virus Of Viral Protein Levels In Host Cell Endoplasmic Reticulum-plasma Membrane Tethering COPII-coated Vesicle Budding Endoplasmic Reticulum Membrane Organization
Pathways			Sphingolipid de novo biosynthesis RHOA GTPase cycle RHOC GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle
Drugs
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Alcoholic chronic pancreatitis ( 28754779) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Bipolar disorder ( 34099189 22925353) Bipolar disorder x sex interaction ( 34099189) Cholesterol, total ( 20686565 24097068) Coenzyme Q10 levels ( 27149984) Coronary artery disease ( 29212778) Gallstone disease ( 30504769) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 19060906 25961943 20686565 20864672 30275531 24097068) HDL cholesterol levels ( 30698716 32203549 28334899) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 33339817) Hip circumference ( 28552196) Macular telangiectasia type 2 ( 33654266) Total cholesterol levels ( 28334899) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
Interacting Genes		3 interacting genes: CRYAA MEOX2 VAPB	49 interacting genes: AIG1 AQP2 AQP6 BIK CD79A CFTR CYB561 CYBRD1 EBAG9 EBP ELOVL4 FAM174A GJA8 GLP1R GPR25 HSD17B13 JAGN1 KCNB1 MAILR MTNR1A OSBP OSBPL2 PTGES REEP4 RETREG3 RMDN2 RNASEK RNF111 SCN3B SLC10A1 SLC18A1 SLC22A1 SQSTM1 STARD3 STX1A STX2 STX4 STX5 TIMMDC1 TMEM101 TMX2 TTC39B USP20 VAMP1 VAMP2 VHL VKORC1 ZBTB22 ZDHHC15
Entrez ID		158219	9217
HPRD ID		10801	09300
Ensembl ID		ENSG00000155158	ENSG00000124164
Uniprot IDs		A0A8V8N5K5 A0A8V8NCV2 A0A8V8PNE1 Q5VTQ0	O95292 Q53XM7
PDB IDs			2MDK 3IKK
Enriched GO Terms of Interacting Partners?		Lens Fiber Cell Morphogenesis Somite Specification Endoplasmic Reticulum Localization FFAT Motif Binding COPII-coated Vesicle Budding Negative Regulation By Virus Of Viral Protein Levels In Host Cell Endoplasmic Reticulum-plasma Membrane Tethering Host-mediated Perturbation Of Viral RNA Genome Replication Tubulin Complex Assembly Response To UV-A Embryonic Camera-type Eye Morphogenesis Lens Morphogenesis In Camera-type Eye Segment Specification Somite Development Host-mediated Activation Of Viral Genome Replication IRE1-mediated Unfolded Protein Response Host-mediated Perturbation Of Viral Genome Replication Endoplasmic Reticulum Membrane Organization Host-mediated Suppression Of Viral Genome Replication Suppression Of Viral Release By Host Structural Constituent Of Eye Lens Embryonic Eye Morphogenesis Apoptotic Process Involved In Morphogenesis Protein Refolding Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Viral Release From Host Cell Positive Regulation Of Viral Genome Replication Endoplasmic Reticulum Exit Site Apoptotic Process Involved In Development Vesicle Budding From Membrane Protein-membrane Adaptor Activity Host-mediated Activation Of Viral Process	Membrane SNAP Receptor Activity SNARE Complex Organic Hydroxy Compound Transport Vesicle Docking SNARE Binding SNARE Complex Assembly Organelle Localization By Membrane Tethering Membrane Docking Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Vesicle Organization Endoplasmic Reticulum Membrane Membrane Fusion Regulation Of Insulin Secretion Endomembrane System Regulation Of Hormone Secretion Membrane Organization Endoplasmic Reticulum Establishment Of Localization In Cell Regulation Of Hormone Levels Regulation Of Peptide Hormone Secretion Ascorbate Homeostasis Exocytosis Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cholesterol Transport Transmembrane Monodehydroascorbate Reductase Activity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Water Transport Transmembrane Transport Basolateral Plasma Membrane Sterol Transport Clathrin-sculpted Monoamine Transport Vesicle Membrane Positive Regulation Of Exocytosis Regulation Of Protein Secretion Protein Binding Cytoplasmic Vesicle Cornified Envelope Assembly Norepinephrine Uptake Secretion By Cell Fluid Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Chloride Channel Inhibitor Activity Neurotransmitter Transport Positive Regulation Of Secretion By Cell Regulation Of Secretion By Cell
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