RNF32 and PSEN2

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		RNF32	PSEN2
Description		ring finger protein 32	presenilin 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Aggresome Nuclear Body	Golgi Membrane Kinetochore Nuclear Inner Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Plasma Membrane Synaptic Vesicle Membrane Nuclear Membrane Protein-containing Complex Presynaptic Membrane Gamma-secretase Complex Synaptic Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Peptidase Activity Hydrolase Activity Aspartic Endopeptidase Activity, Intramembrane Cleaving
	Biological Process		Response To Hypoxia Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Amyloid-beta Formation Intracellular Signal Transduction Amyloid Precursor Protein Catabolic Process Calcium Ion Homeostasis Regulation Of Calcium Import Into The Mitochondrion Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways			Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 TGFBR3 PTM regulation
Drugs
Diseases			Alzheimer's disease (AD)
GWAS		Glomerular filtration rate (creatinine) ( 26831199)	Heel bone mineral density ( 30598549) Refractive error ( 32231278)
Interacting Genes		42 interacting genes: A2M APOE APP BLMH CDC37 CDK5 CEP55 CYP2C8 CYP2C9 ECSIT ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 FIBP GCDH HOXC4 IFIT3 IFIT5 LONP1 LOXL4 LZTS2 MAST1 MKRN3 MNAT1 NOS3 OGA PAXIP1 PRAM1 PRDX2 PSEN1 PSEN2 RAB3A RAB3D RAD23A RPP30 STAMBPL1 TRIM23 TRIM74 UBE2K	61 interacting genes: AAMP ACTG1 AP1G1 APH1A APH1B APP AURKA BCL2L1 CAPN1 CASP1 CASP3 CASP6 CASP7 CASP8 CEP55 CFLAR CHKA CIB1 CSNK1A1 CSNK1D CSNK2A1 CTNNB1 CTNND2 DNAJB1 DOCK3 ECD EID1 ELAVL1 EVI5L EXOC6 FBXL12 FHL2 FLNA FLNB GCDH GFAP HLA-DMB HPS1 ICAM5 IFIT3 IFIT5 KCNIP3 KCNIP4 LIPF MAST1 METTL2B NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OGA PDCD4 PSENEN RAB11A RHEB RNF32 SPC24 SRI UBQLN1
Entrez ID		140545	5664
HPRD ID		11517	02860
Ensembl ID		ENSG00000105982	ENSG00000143801
Uniprot IDs		G5E940 Q9H0A6	P49810
PDB IDs			7Y5X 7Y5Z
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Fibril Formation Lipoprotein Particle Catabolic Process Acetylcholine Receptor Activator Activity Cellular Response To Amyloid-beta Regulation Of Amyloid Fibril Formation Response To Amyloid-beta Amyloid Precursor Protein Metabolic Process Astrocyte Activation Involved In Immune Response Caffeine Oxidase Activity Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Aspartic Endopeptidase Activity, Intramembrane Cleaving Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Gamma-secretase Complex Regulation Of Synaptic Plasticity Macromolecule Catabolic Process Oxidative Demethylation Positive Regulation Of Regulated Secretory Pathway Regulation Of Regulated Secretory Pathway Omega-hydroxylase P450 Pathway Arachidonate Epoxygenase Activity Amyloid-beta Formation Notch Receptor Processing Regulation Of Proteolysis Regulation Of Vesicle-mediated Transport Demethylation Synaptic Vesicle Regulation Of Neuronal Synaptic Plasticity Regulation Of Postsynapse Organization Negative Regulation Of Long-term Synaptic Potentiation Growth Cone Regulation Of Immune Response Regulation Of Dendritic Spine Maintenance Neuron Projection Maintenance Epoxygenase P450 Pathway Synaptic Membrane Mitotic Cytokinesis Low-density Lipoprotein Particle Removal Of Superoxide Radicals Regulation Of Blood Coagulation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Myosin V Binding Regulation Of Innate Immune Response Regulation Of Hemostasis Amyloid Precursor Protein Catabolic Process Maintenance Of Location In Cell Heparan Sulfate Proteoglycan Binding Negative Regulation Of Platelet Activation Astrocyte Activation	Cytosol Notch Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Cell Surface Receptor Signaling Pathway Gamma-secretase Complex Cytoplasm Protein Processing Notch Receptor Processing Amyloid-beta Formation Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activity Membrane Protein Intracellular Domain Proteolysis Protein Maturation Cellular Response To Staurosporine Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Cysteine-type Peptidase Activity Pyroptotic Inflammatory Response Luteolysis Endopeptidase Activator Activity Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Organelle Assembly Death-inducing Signaling Complex Amyloid Precursor Protein Metabolic Process Amyloid-beta Metabolic Process Execution Phase Of Apoptosis Golgi Membrane Proteolysis Positive Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Regulation Of Neuron Apoptotic Process Positive Regulation Of Programmed Cell Death Signal Transduction Regulation Of Signal Transduction Membrane Protein Proteolysis Regulation Of Autophagy Positive Regulation Of Proteolysis Cellular Response To Alkaloid Organelle Organization Angiogenesis Negative Regulation Of Programmed Cell Death Ovulation Cycle Process Regulation Of Protein Metabolic Process Regulation Of Smooth Muscle Cell Differentiation
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