RNF32 and A2M

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		RNF32	A2M
Description		ring finger protein 32	alpha-2-macroglobulin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Aggresome Nuclear Body	Extracellular Region Extracellular Space Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Peptidase Inhibitor Activity Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process		Negative Regulation Of Complement Activation, Lectin Pathway Stem Cell Differentiation
Pathways			Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix HDL assembly
Drugs			Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Glomerular filtration rate (creatinine) ( 26831199)	Refractive error ( 32231278)
Interacting Genes		42 interacting genes: A2M APOE APP BLMH CDC37 CDK5 CEP55 CYP2C8 CYP2C9 ECSIT ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 FIBP GCDH HOXC4 IFIT3 IFIT5 LONP1 LOXL4 LZTS2 MAST1 MKRN3 MNAT1 NOS3 OGA PAXIP1 PRAM1 PRDX2 PSEN1 PSEN2 RAB3A RAB3D RAD23A RPP30 STAMBPL1 TRIM23 TRIM74 UBE2K	99 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSP90AA1 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SLC6A4 SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS USP40
Entrez ID		140545	2
HPRD ID		11517	00072
Ensembl ID		ENSG00000105982	ENSG00000175899
Uniprot IDs		G5E940 Q9H0A6	P01023
PDB IDs			1BV8 2P9R 6TAV 7O7L 7O7M 7O7N 7O7O 7O7P 7O7Q 7O7R 7O7S 7VON 7VOO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Fibril Formation Lipoprotein Particle Catabolic Process Acetylcholine Receptor Activator Activity Cellular Response To Amyloid-beta Regulation Of Amyloid Fibril Formation Response To Amyloid-beta Amyloid Precursor Protein Metabolic Process Astrocyte Activation Involved In Immune Response Caffeine Oxidase Activity Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Aspartic Endopeptidase Activity, Intramembrane Cleaving Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Gamma-secretase Complex Regulation Of Synaptic Plasticity Macromolecule Catabolic Process Oxidative Demethylation Positive Regulation Of Regulated Secretory Pathway Regulation Of Regulated Secretory Pathway Omega-hydroxylase P450 Pathway Arachidonate Epoxygenase Activity Amyloid-beta Formation Notch Receptor Processing Regulation Of Proteolysis Regulation Of Vesicle-mediated Transport Demethylation Synaptic Vesicle Regulation Of Neuronal Synaptic Plasticity Regulation Of Postsynapse Organization Negative Regulation Of Long-term Synaptic Potentiation Growth Cone Regulation Of Immune Response Regulation Of Dendritic Spine Maintenance Neuron Projection Maintenance Epoxygenase P450 Pathway Synaptic Membrane Mitotic Cytokinesis Low-density Lipoprotein Particle Removal Of Superoxide Radicals Regulation Of Blood Coagulation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Myosin V Binding Regulation Of Innate Immune Response Regulation Of Hemostasis Amyloid Precursor Protein Catabolic Process Maintenance Of Location In Cell Heparan Sulfate Proteoglycan Binding Negative Regulation Of Platelet Activation Astrocyte Activation	Negative Regulation Of Multicellular Organismal Process Extracellular Exosome Extracellular Space Peptidase Activity Ovulation From Ovarian Follicle Regulation Of Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hydrolase Activity Ovulation Regulation Of Multicellular Organismal Process Response To Stress Regulation Of Blood Coagulation Negative Regulation Of Platelet Activation Regulation Of Hemostasis Extracellular Region Regulation Of Amyloid-beta Clearance Positive Regulation Of Cell Adhesion Smooth Muscle Adaptation Regulation Of Programmed Cell Death Regulation Of Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Positive Regulation Of Amyloid-beta Clearance Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Proteolysis Negative Regulation Of Coagulation Regulation Of Cell Adhesion Regulation Of Biological Quality Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Apoptotic Process Positive Regulation Of Cell Activation Identical Protein Binding Positive Regulation Of Protein Metabolic Process Protein Refolding Positive Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Lymphocyte Activation Regulation Of Transport Melanosome Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Smooth Muscle Cell Proliferation Serine-type Endopeptidase Activity Positive Regulation Of Cell Motility Extracellular Matrix Lipoprotein Particle Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process
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