RNF32 and CYP2C8

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		RNF32	CYP2C8
Gene Name		ring finger protein 32	cytochrome P450, family 2, subfamily C, polypeptide 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Aggresome	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Zinc Ion Binding	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Caffeine Oxidase Activity Aromatase Activity
	Biological Process		Organic Acid Metabolic Process Xenobiotic Metabolic Process Drug Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Exogenous Drug Catabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Oxidative Demethylation Omega-hydroxylase P450 Pathway
Pathways			Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Arachidonic acid metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type CYP2E1 reactions Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS			Immune response to smallpox vaccine (IL-6) ( 22542470) Osteonecrosis of the jaw ( 18594024) Response to clopidogrel therapy ( 19706858) Warfarin maintenance dose ( 23755828)
Protein-Protein Interactions		42 interactors: A2M APOE APP BLMH CDC37 CDK5 CEP55 CYP2C8 CYP2C9 ECSIT ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 FIBP GCDH HOXC4 IFIT3 IFIT5 LONP1 LOXL4 LZTS2 MAST1 MGEA5 MKRN3 MNAT1 NOS3 PAXIP1 PRAM1 PRDX2 PSEN1 PSEN2 RAB3A RAB3D RAD23A RPP30 STAMBPL1 TRIM23 TRIM74 UBE2K	11 interactors: A2M APOE BLMH DNAJB1 ECSIT EXOC6 IFIT3 LONP1 MAST1 PSEN1 RNF32
Entrez ID		140545	1558
HPRD ID		11517	03083
Ensembl ID		ENSG00000105982	ENSG00000138115
Uniprot IDs		Q9H0A6	B7Z1F5 P10632
PDB IDs			1PQ2 2NNH 2NNI 2NNJ 2VN0
Enriched GO Terms of Interacting Partners?		Catabolic Process Exocytosis Synaptic Vesicle Exocytosis Protein Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Protein Metabolic Process Regulation Of Synaptic Plasticity Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Response To Stress Response To Stimulus Endoplasmic Reticulum Calcium Ion Homeostasis Secretion By Cell Neurotransmitter Secretion Synaptic Vesicle Transport Regulation Of Protein Metabolic Process Regulation Of Receptor Activity Negative Regulation Of Cellular Protein Metabolic Process Protein Catabolic Process Cellular Response To Stimulus Establishment Of Localization In Cell Cellular Macromolecule Catabolic Process Secretion Regulation Of Neurotransmitter Levels Negative Regulation Of Protein Metabolic Process Amyloid Precursor Protein Catabolic Process Omega-hydroxylase P450 Pathway Regulation Of Protein Binding Establishment Of Protein Localization Cellular Metabolic Process Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Vesicle Docking Involved In Exocytosis Regulation Of Synaptic Transmission Intracellular Signal Transduction Positive Regulation Of Exocytosis Neurotransmitter Transport Negative Regulation Of Cell Death Neuron Death Regulation Of Protein Kinase Activity Establishment Of Organelle Localization Synapse Organization Protein Localization Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Oxidative Demethylation Regulation Of Kinase Activity Negative Regulation Of Neuron Differentiation Regulation Of ERBB Signaling Pathway	Regulation Of Inclusion Body Assembly Response To Stress Protein Metabolic Process Exocytosis Oxidation-dependent Protein Catabolic Process Cajal-Retzius Cell Differentiation Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Beta-amyloid Formation Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Regulation Of Oxidoreductase Activity Response To Stimulus Response To Oxidative Stress Regulation Of Cellular Component Organization Extracellular Matrix Disassembly Establishment Of Localization In Cell Positive Regulation Of Neurofibrillary Tangle Assembly Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Cellular Response To Stimulus Secretion By Cell Immune System Process Negative Regulation Of Neuron Projection Development Positive Regulation Of Phospholipid Efflux Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Mitochondrial DNA Replication Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Cell Projection Organization Regulation Of Catalytic Activity Synaptic Vesicle Targeting Regulation Of Resting Membrane Potential Cellular Localization Positive Regulation Of Cellular Protein Catabolic Process Maintenance Of Location In Cell Regulation Of Axonogenesis Secretion Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Tau-protein Kinase Activity Response To Aluminum Ion Negative Regulation Of Cholesterol Efflux N-methyl-D-aspartate Receptor Clustering Regulation Of Presynaptic Membrane Organization
Tagcloud ?			allele apolipoprotein associations cardiotoxicity commonly comt conform epsilon4 failed fatigue genetic genotype guidelines il6 impairment listed lle655val met neuropathy polymorphisms reporting strega systematic toxicities transparent underlying val variant variants
Tagcloud (Difference) ?			allele apolipoprotein associations cardiotoxicity commonly comt conform epsilon4 failed fatigue genetic genotype guidelines il6 impairment listed lle655val met neuropathy polymorphisms reporting strega systematic toxicities transparent underlying val variant variants
Tagcloud (Intersection) ?