CRMP1 and VCP

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CRMP1	VCP
Gene Name		collapsin response mediator protein 1	valosin containing protein
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Spindle Cytosol Dendrite Neuronal Cell Body	Proteasome Complex Hrd1p Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Particle Cytosol Site Of Double-strand Break Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides	Receptor Binding Protein Binding ATP Binding Lipid Binding ATPase Activity Protein Phosphatase Binding Protein Domain Specific Binding Polyubiquitin Binding Protein Complex Binding Deubiquitinase Activator Activity Identical Protein Binding ADP Binding Poly(A) RNA Binding Ubiquitin-specific Protease Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Nervous System Development Axon Guidance	DNA Repair Double-strand Break Repair ER To Golgi Vesicle-mediated Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine Translesion Synthesis ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Hexamerization Cellular Response To Heat Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Protein Homooligomerization Aggresome Assembly Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Lys63-specific Deubiquitinase Activity
Pathways		Axon guidance Semaphorin interactions CRMPs in Sema3A signaling	HSF1 activation Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog Cellular response to heat stress
Drugs
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494)
Protein-Protein Interactions		78 interactors: AGR2 ALDH2 AMFR ANXA7 AP3M1 ARL15 AXIN1 BID BTBD2 CACNA1A CCDC106 CCL18 CCT7 CDK5RAP2 CDK5RAP3 DDX18 DNAJB11 DPYSL2 DPYSL3 DUSP4 EEF1D EIF2S2 EPN1 EXOSC8 FAS FTH1 FUBP1 FXR1 GNE GOLGA2 HDHD2 HGS HMGB1 HNRNPH1 HNRNPH3 HNRNPUL1 HSPE1 HTT IL33 KLHL20 LRRC1 LSM2 MAPK8IP2 MCM3AP MOB4 MRPS12 NAT9 NDUFV2 NVL PAFAH1B3 PFN1 PLA2G2A PMF1 PPP1R8 PSMD11 RGL2 RGS2 ROCK1 RPA2 RPS6KA5 RTN4 SAT1 SEPHS1 SERPINB9 SNRPG SPRY2 SRC TFG TK1 TRIP13 TSC22D1 UBE2A UBE2B VCP VIM YAE1D1 ZAK ZNF24	72 interactors: AMFR AR ASPSCR1 ATG5 ATXN1 ATXN3 ATXN7 BRCA1 BRSK2 CAV1 CEP19 CRMP1 DERL1 DGCR6 DTNB FAM104A GZMK HDAC6 HERPUD1 HTT INSIG1 INSIG2 JAK2 LNX1 MAPK8IP2 NDRG1 NF1 NFKBIA NGLY1 NPLOC4 NSFL1C NUB1 OTULIN PLAA PRKCD PSMA1 PSMA7 PSMC1 PTPN3 RNF19A RNF31 RNF8 RPL9 RPS6KA1 SH2D2A SIK2 STUB1 STX5 SUMO4 SVIP SYVN1 TOM1L1 TOMM34 UBE4A UBE4B UBOX5 UBQLN1 UBXN1 UBXN2A UBXN2B UBXN6 UFD1L VCPIP1 VCPKMT VIMP WAC WBSCR22 WDYHV1 WRN YOD1 YWHAZ ZFAND2B
Entrez ID		1400	7415
HPRD ID		03913	03013
Ensembl ID		ENSG00000072832	ENSG00000165280
Uniprot IDs		B3KT07 E9PD68 Q14194 Q96I11	P55072 Q96IF9
PDB IDs		4B3Z	3EBB 3HU1 3HU2 3HU3 3QC8 3QQ7 3QQ8 3QWZ 3TIW
Enriched GO Terms of Interacting Partners?		Cell Death Death Developmental Process Apoptotic Process Programmed Cell Death Anatomical Structure Development Regulation Of Cellular Protein Metabolic Process Cell Differentiation Catabolic Process Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Proteolysis Regulation Of Cysteine-type Endopeptidase Activity Response To Stimulus Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Organic Substance Protein Homooligomerization Response To Stress Protein Polyubiquitination Positive Regulation Of Protein Complex Assembly Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Nitrogen Compound Metabolic Process Cellular Response To Stimulus Multicellular Organismal Development Cytoskeleton Organization Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Proteolysis Cellular Process Stress-activated MAPK Cascade Nervous System Development Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Metabolic Process Cellular Component Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity System Development Positive Regulation Of Catalytic Activity Postreplication Repair Regulation Of Cellular Component Organization Protein Oligomerization Cellular Macromolecule Catabolic Process Positive Regulation Of Endopeptidase Activity Regulation Of Protein Complex Assembly Heterocycle Metabolic Process	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Protein Modification By Small Protein Conjugation Protein Ubiquitination Response To Stress Catabolic Process Protein Metabolic Process Protein Polyubiquitination Cellular Metabolic Process Regulation Of Protein Ubiquitination Cellular Protein Modification Process Cellular Response To Topologically Incorrect Protein ER-nucleus Signaling Pathway Golgi Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cell Communication Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stimulus Negative Regulation Of Apoptotic Process Regulation Of Proteolysis Negative Regulation Of Programmed Cell Death Regulation Of Cell Death Negative Regulation Of Cellular Protein Metabolic Process Apoptotic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Metabolic Process Negative Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Cellular Response To Unfolded Protein Programmed Cell Death Negative Regulation Of Protein Metabolic Process Cell Death Death Negative Regulation Of Signal Transduction Response To Stimulus Response To Unfolded Protein Negative Regulation Of Signaling
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	17q11 3q28 9pter ap2 ap50 aps blots clapb1 clapm1 clathrin coated denoted designated dnas endocytosis lattice locations mapped maps oligonucleotide porcine primers probe q12 q34 rodent served stoichiometric triskelia
Tagcloud (Difference) ?		aldh1a1 anxa1 bcar1 cldn1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	17q11 3q28 9pter ap2 ap50 aps blots clapb1 clapm1 clathrin coated denoted designated dnas endocytosis lattice locations mapped maps oligonucleotide porcine primers probe q12 q34 rodent served stoichiometric triskelia
Tagcloud (Intersection) ?