CRMP1 and PLA2G2A

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		CRMP1	PLA2G2A
Description		collapsin response mediator protein 1	phospholipase A2 group IIA
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Actin Cytoskeleton Dendrite Growth Cone Midbody Cell Projection Neuronal Cell Body Perikaryon Presynapse Postsynapse	Extracellular Region Extracellular Space Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Secretory Granule Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Filamin Binding Identical Protein Binding Phosphoprotein Binding	Catalytic Activity Phospholipase A2 Activity Calcium Ion Binding Phospholipid Binding Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Nervous System Development Negative Regulation Of Neuron Projection Development Semaphorin-plexin Signaling Pathway Regulation Of Postsynapse Assembly	Lipid Metabolic Process Phospholipid Metabolic Process Inflammatory Response Positive Regulation Of Macrophage Derived Foam Cell Differentiation Lipid Catabolic Process Killing Of Cells Of Another Organism Low-density Lipoprotein Particle Remodeling Intestinal Stem Cell Homeostasis Angiotensin-activated Signaling Pathway Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Arachidonate Secretion Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Neutrophil Activation
Pathways		CRMPs in Sema3A signaling	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA Antimicrobial peptides
Drugs			Indomethacin Ginkgo biloba 1,4-Butanediol 1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene N-Tridecanoic Acid [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid 4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid Lauric acid (1-Benzyl-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid 6-phenyl-4(R)-(7-phenyl-heptanoylamino)-hexanoic acid Elaidamide (2R)-2-Acetamido-3-(octadecyloxy)propyl 2-(methylsulfanyl)ethyl hydrogen phosphate KH064 Suramin Varespladib methyl
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545)	Blood protein levels ( 30072576) Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) Immunoglobulin light chain (AL) amyloidosis ( 28025584)
Interacting Genes		81 interacting genes: AGR2 ALDH2 AMFR ANXA7 AP3M1 ARL15 AXIN1 BID BTBD2 CACNA1A CCDC106 CCL18 CCT7 CDK5RAP2 CDK5RAP3 DDX18 DISC1 DNAJB11 DPYSL2 DUSP4 EEF1D EIF2S2 EPN1 EXOSC8 FAS FTH1 FUBP1 FXR1 GNE GOLGA2 HDHD2 HGS HMGB1 HNRNPH1 HNRNPH3 HNRNPUL1 HSPE1 HTT IL33 KLHL20 LRRC1 LRRK2 LSM2 MAP3K20 MAPK8IP2 MCM3AP MOB4 MRPS12 NAT9 NDUFV2 NVL PAFAH1B3 PFN1 PLA2G2A PMF1 PPP1R8 PSMD11 RACK1 RGL2 RGS2 ROCK1 RPA2 RPS6KA5 RSPH1 RTN4 SAT1 SEPHS1 SERPINB9 SNRPG SPRY2 SRC TFG TK1 TRIP13 TSC22D1 UBE2A UBE2B VCP VIM YAE1 ZNF24	26 interacting genes: ALOX12 BAG6 CEP70 CRMP1 DCN ITGAV ITGB3 JOSD2 PLA2G1B PLA2R1 SENP6 SENP8 UCHL1 UCHL3 UCHL5 USP15 USP2 USP20 USP28 USP4 USP47 USP5 USP7 USP8 VCAN VIM
Entrez ID		1400	5320
HPRD ID		03913	01397
Ensembl ID		ENSG00000072832	ENSG00000188257
Uniprot IDs		B3KT07 B3KV96 E9PD68 Q14194 Q96I11 X5DNI1	P14555
PDB IDs		4B3Z	1AYP 1BBC 1DB4 1DB5 1DCY 1J1A 1KQU 1KVO 1N28 1N29 1POD 1POE 3U8B 3U8D 3U8H 3U8I 5G3N
Enriched GO Terms of Interacting Partners?		Cytoplasm Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytosol Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Identical Protein Binding RNA Binding Positive Regulation Of Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteolysis Protein Binding Protein-containing Complex Organization Organelle Organization Regulation Of Signal Transduction Cytoskeleton Organization Regulation Of Proteolysis Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Programmed Cell Death Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Mitochondrial Membrane Potential Cellular Component Assembly Nucleus Regulation Of Programmed Cell Death Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Regulation Of Protein Binding Regulation Of MAPK Cascade Protein-containing Complex Assembly Regulation Of Apoptotic Process Perinuclear Region Of Cytoplasm BAT3 Complex Binding Regulation Of Wnt Signaling Pathway Regulation Of Mitochondrial Depolarization Catabolic Process Positive Regulation Of Autophagy Regulation Of Cellular Response To Stress Regulation Of Protein Metabolic Process Regulation Of CAMKK-AMPK Signaling Cascade Negative Regulation Of Hippo Signaling HULC Complex Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Branching Morphogenesis Of A Nerve Ubiquitin-like Protein Ligase Binding Macromolecule Metabolic Process Microtubule Cytoskeleton Organization	Protein Modification By Small Protein Removal Protein Deubiquitination Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Peptidase Activity Deubiquitinase Activity Post-translational Protein Modification Hydrolase Activity Proteolysis Cysteine-type Endopeptidase Activity Protein Modification Process Regulation Of Protein Stability Protein Metabolic Process Monoubiquitinated Protein Deubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Integrin Alphav-beta3 Complex Negative Regulation Of Protein Metabolic Process Positive Regulation Of Podocyte Apoptotic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process K48-linked Deubiquitinase Activity Cytosol Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Biological Quality Protein K48-linked Deubiquitination Extracellular Matrix Binding Alphav-beta3 Integrin-IGF-1-IGF1R Complex Regulation Of Intracellular Signal Transduction Apolipoprotein A-I-mediated Signaling Pathway C-X3-C Chemokine Binding Negative Regulation Of Lipoprotein Metabolic Process Neuregulin Binding Negative Regulation Of Lipid Transport DeNEDDylase Activity Macromolecule Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Positive Regulation Of Signal Transduction Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Ubiquitin-dependent Protein Catabolic Process Extracellular Matrix Structural Constituent Conferring Compression Resistance Insulin-like Growth Factor I Binding Positive Regulation Of Osteoblast Proliferation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Catabolic Process
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