CRMP1 and IL33

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		CRMP1	IL33
Gene Name		collapsin response mediator protein 1	interleukin 33
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Spindle Cytosol Dendrite Neuronal Cell Body	Extracellular Space Nucleus Chromosome Transport Vesicle
	Molecular Function	Protein Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides	Cytokine Activity Protein Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Nervous System Development Axon Guidance	Negative Regulation Of Leukocyte Migration Negative Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Type 2 Immune Response Transcription, DNA-templated Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Type 2 Immune Response Positive Regulation Of Macrophage Activation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Inflammatory Response Positive Regulation Of Immunoglobulin Secretion Negative Regulation Of Immunoglobulin Secretion Positive Regulation Of Chemokine Secretion Extrinsic Apoptotic Signaling Pathway
Pathways		Axon guidance Semaphorin interactions CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494)	Asthma ( 21804549 20860503) Endometriosis ( 23472165) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		78 interactors: AGR2 ALDH2 AMFR ANXA7 AP3M1 ARL15 AXIN1 BID BTBD2 CACNA1A CCDC106 CCL18 CCT7 CDK5RAP2 CDK5RAP3 DDX18 DNAJB11 DPYSL2 DPYSL3 DUSP4 EEF1D EIF2S2 EPN1 EXOSC8 FAS FTH1 FUBP1 FXR1 GNE GOLGA2 HDHD2 HGS HMGB1 HNRNPH1 HNRNPH3 HNRNPUL1 HSPE1 HTT IL33 KLHL20 LRRC1 LSM2 MAPK8IP2 MCM3AP MOB4 MRPS12 NAT9 NDUFV2 NVL PAFAH1B3 PFN1 PLA2G2A PMF1 PPP1R8 PSMD11 RGL2 RGS2 ROCK1 RPA2 RPS6KA5 RTN4 SAT1 SEPHS1 SERPINB9 SNRPG SPRY2 SRC TFG TK1 TRIP13 TSC22D1 UBE2A UBE2B VCP VIM YAE1D1 ZAK ZNF24	5 interactors: CASP1 CRMP1 HIST2H2AA3 HIST2H2BE IL1RL1
Entrez ID		1400	90865
HPRD ID		03913	12275
Ensembl ID		ENSG00000072832	ENSG00000137033
Uniprot IDs		B3KT07 E9PD68 Q14194 Q96I11	O95760
PDB IDs		4B3Z	2KLL 4KC3
Enriched GO Terms of Interacting Partners?		Cell Death Death Developmental Process Apoptotic Process Programmed Cell Death Anatomical Structure Development Regulation Of Cellular Protein Metabolic Process Cell Differentiation Catabolic Process Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Proteolysis Regulation Of Cysteine-type Endopeptidase Activity Response To Stimulus Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Organic Substance Protein Homooligomerization Response To Stress Protein Polyubiquitination Positive Regulation Of Protein Complex Assembly Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Nitrogen Compound Metabolic Process Cellular Response To Stimulus Multicellular Organismal Development Cytoskeleton Organization Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Proteolysis Cellular Process Stress-activated MAPK Cascade Nervous System Development Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Metabolic Process Cellular Component Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity System Development Positive Regulation Of Catalytic Activity Postreplication Repair Regulation Of Cellular Component Organization Protein Oligomerization Cellular Macromolecule Catabolic Process Positive Regulation Of Endopeptidase Activity Regulation Of Protein Complex Assembly Heterocycle Metabolic Process	Positive Regulation Of Cytokine Secretion Interleukin-33-mediated Signaling Pathway Regulation Of Cytokine Secretion Mitochondrial Depolarization Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Protein Secretion Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Regulation Of Inflammatory Response Immune Response Negative Regulation Of T-helper 1 Type Immune Response Pyrimidine Nucleobase Catabolic Process Positive Regulation Of Secretion Positive Regulation Of Chemokine Secretion Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Positive Regulation Of Macrophage Activation Regulation Of Protein Secretion Interleukin-1 Beta Production Positive Regulation Of Interleukin-5 Production Innate Immune Response In Mucosa Response To Bacterium Response To External Stimulus Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Cytokine Production Regulation Of Interleukin-1 Beta Secretion Regulation Of Macrophage Activation Regulation Of Interleukin-5 Production Response To ATP Antibacterial Humoral Response Antimicrobial Humoral Response Positive Regulation Of Interleukin-1 Beta Production Regulation Of Protein Transport Immune System Process Positive Regulation Of Interleukin-1 Production Mucosal Immune Response Regulation Of Secretion Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Interferon-gamma Production Regulation Of Establishment Of Protein Localization Negative Regulation Of Adaptive Immune Response Membrane Hyperpolarization Pyrimidine Nucleobase Metabolic Process Toxin Transport Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Other Organism Positive Regulation Of Chemokine Production Positive Regulation Of Transport
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	10ko acp5 aia arthritic arthritis autoinflammatory blockade casp1 driven erosions ex exogenous focal hence histological histopathology il1b inflammasome investigative joint neutralization nlrp3 osteoclast osteoclastogenesis pathology radiographic synovial synovium tartrate
Tagcloud (Difference) ?		aldh1a1 anxa1 bcar1 cldn1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	10ko acp5 aia arthritic arthritis autoinflammatory blockade casp1 driven erosions ex exogenous focal hence histological histopathology il1b inflammasome investigative joint neutralization nlrp3 osteoclast osteoclastogenesis pathology radiographic synovial synovium tartrate
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