MATN2 and FBN2

Number of citations of the paper that reports this interaction (PMID 12180907)
9

Data Source:
HPRD (in vitro)

		MATN2	FBN2
Gene Name		matrilin 2	fibrillin 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Basement Membrane Extracellular Matrix	Microfibril Extracellular Region Proteinaceous Extracellular Matrix Extracellular Matrix
	Molecular Function	Molecular_function Calcium Ion Binding Protein Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Neuron Migration Axon Guidance Biological_process Glial Cell Migration Dendrite Regeneration Response To Axon Injury	Anatomical Structure Morphogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Sequestering Of TGFbeta In Extracellular Matrix Positive Regulation Of Osteoblast Differentiation Bone Trabecula Formation
Pathways			Molecules associated with elastic fibres Elastic fibre formation Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065)	Height ( 21998595) Obesity (extreme) ( 19553259) Temperament ( 22832960)
Protein-Protein Interactions		18 interactors: ATXN1 ATXN1L ATXN7 CACNA1A CBFA2T3 COL1A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 DVL3 FBN2 FN1 MATN1 MATN3 MATN4	7 interactors: ELN FBN1 LTBP1 MATN2 MFAP2 MFAP5 SMAD2
Entrez ID		4147	2201
HPRD ID		03660	00416
Ensembl ID		ENSG00000132561	ENSG00000138829
Uniprot IDs		O00339 Q8N2G3	P35556
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process System Development Multicellular Organismal Development Cell Morphogenesis Involved In Differentiation Anatomical Structure Development Developmental Process Anatomical Structure Morphogenesis Cell Morphogenesis Organ Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Axon Guidance Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Neuron Projection Development Locomotion Cell Development Cell Projection Morphogenesis Cell Part Morphogenesis Bone Trabecula Formation Axonogenesis Cell Differentiation Neuron Development Axon Development Movement Of Cell Or Subcellular Component Chemotaxis Glomerular Basement Membrane Development Anatomical Structure Formation Involved In Morphogenesis Generation Of Neurons Bone Trabecula Morphogenesis Neuron Differentiation Neurogenesis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Projection Organization Catabolic Process Response To External Stimulus Synapse Organization Cardiovascular System Development Cartilage Development Involved In Endochondral Bone Morphogenesis Endodermal Cell Differentiation Blood Vessel Development Vasculature Development Trabecula Morphogenesis Skeletal System Development Neuromuscular Junction Development	Extracellular Matrix Organization Extracellular Structure Organization Sequestering Of TGFbeta In Extracellular Matrix Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Extracellular Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of BMP Signaling Pathway Dendrite Regeneration Extracellular Matrix Disassembly Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Maintenance Of Protein Location Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Zygotic Specification Of Dorsal/ventral Axis Sequestering Of BMP In Extracellular Matrix Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Mesoderm Development Primary MiRNA Processing Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway System Development Negative Regulation Of Signal Transduction Anatomical Structure Morphogenesis Extracellular Fibril Organization Kidney Development SMAD Protein Complex Assembly Negative Regulation Of Signaling Renal System Development Paraxial Mesoderm Morphogenesis Stress Fiber Assembly Multicellular Organismal Development Nodal Signaling Pathway Urogenital System Development Anatomical Structure Development Organ Development Production Of MiRNAs Involved In Gene Silencing By MiRNA Platelet Formation Embryonic Foregut Morphogenesis Platelet Morphogenesis Foregut Morphogenesis Regulation Of Activin Receptor Signaling Pathway Paraxial Mesoderm Development Response To Cholesterol Dorsal/ventral Axis Specification
Tagcloud ?		amplifiable analyte angpt2 aptamer c7 cdta clostridium crdl1 difficile du exponential gpvi hold lumavidin luminex multiplexed naphthylmethyl panels picomolar plg radiolabel reagents sandwich selex somamer somamers tryptaminocarbonyl tsp2 wise	aldh1a1 asct beadchip carries cep192 cpeb1 detoxification dhrs7c dmrta1 flj35282 grades gwas humanomni1 illumina interrupted jph3 linc00692 looked melphalan mucositis om predisposition quad sequelae snps tt2 tt3 tt4 v1
Tagcloud (Difference) ?		amplifiable analyte angpt2 aptamer c7 cdta clostridium crdl1 difficile du exponential gpvi hold lumavidin luminex multiplexed naphthylmethyl panels picomolar plg radiolabel reagents sandwich selex somamer somamers tryptaminocarbonyl tsp2 wise	aldh1a1 asct beadchip carries cep192 cpeb1 detoxification dhrs7c dmrta1 flj35282 grades gwas humanomni1 illumina interrupted jph3 linc00692 looked melphalan mucositis om predisposition quad sequelae snps tt2 tt3 tt4 v1
Tagcloud (Intersection) ?