MATN2 and COL1A1

Number of citations of the paper that reports this interaction (PMID 12180907)
9

Data Source:
HPRD (in vitro, in vivo)

		MATN2	COL1A1
Gene Name		matrilin 2	collagen, type I, alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Basement Membrane Extracellular Matrix	Extracellular Region Collagen Type I Trimer Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Secretory Granule Extracellular Matrix
	Molecular Function	Molecular_function Calcium Ion Binding Protein Binding	Extracellular Matrix Structural Constituent Protein Binding Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Neuron Migration Axon Guidance Biological_process Glial Cell Migration Dendrite Regeneration Response To Axon Injury	Skeletal System Development Blood Vessel Development Osteoblast Differentiation Intramembranous Ossification Endochondral Ossification Receptor-mediated Endocytosis Blood Coagulation Visual Perception Sensory Perception Of Sound Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell-substrate Adhesion Protein Transport Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Corticosteroid Response To Estradiol Collagen Biosynthetic Process Protein Localization To Nucleus Tooth Mineralization Response To Drug Response To Hydrogen Peroxide Response To Peptide Hormone Skin Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Tooth Eruption Positive Regulation Of Transcription, DNA-templated Embryonic Skeletal System Development Leukocyte Migration Response To CAMP Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Cartilage Development Involved In Endochondral Bone Morphogenesis Protein Heterotrimerization Cellular Response To Amino Acid Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Vitamin E Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Fluoride
Pathways			Platelet Adhesion to exposed collagen Collagen formation Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Syndecan interactions Crosslinking of collagen fibrils ECM proteoglycans GPVI-mediated activation cascade Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Platelet activation, signaling and aggregation Scavenging by Class A Receptors
Drugs			Collagenase
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065)	Breast cancer ( 17903305) Response to taxane treatment (docetaxel) ( 23006423)
Protein-Protein Interactions		18 interactors: ATXN1 ATXN1L ATXN7 CACNA1A CBFA2T3 COL1A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 DVL3 FBN2 FN1 MATN1 MATN3 MATN4	37 interactors: ACHE ATP13A2 BARD1 BGN BMP1 BRCA1 CAPN1 CD36 CD44 CD93 COL7A1 DCN DDR2 FGF7 FN1 HTRA1 IGFBP3 ITGA2 ITGA5 MAG MATN2 MMP2 MMP9 NID1 NID2 P4HB PAK1 PDGFA PDGFB PKD1 PRELP SPARC TGFBI THBS1 TMPRSS6 TXN VWF
Entrez ID		4147	1277
HPRD ID		03660	00362
Ensembl ID		ENSG00000132561	ENSG00000108821
Uniprot IDs		O00339 Q8N2G3	P02452
PDB IDs			1Q7D 2LLP 3EJH 3GXE
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process System Development Multicellular Organismal Development Cell Morphogenesis Involved In Differentiation Anatomical Structure Development Developmental Process Anatomical Structure Morphogenesis Cell Morphogenesis Organ Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Axon Guidance Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Neuron Projection Development Locomotion Cell Development Cell Projection Morphogenesis Cell Part Morphogenesis Bone Trabecula Formation Axonogenesis Cell Differentiation Neuron Development Axon Development Movement Of Cell Or Subcellular Component Chemotaxis Glomerular Basement Membrane Development Anatomical Structure Formation Involved In Morphogenesis Generation Of Neurons Bone Trabecula Morphogenesis Neuron Differentiation Neurogenesis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Projection Organization Catabolic Process Response To External Stimulus Synapse Organization Cardiovascular System Development Cartilage Development Involved In Endochondral Bone Morphogenesis Endodermal Cell Differentiation Blood Vessel Development Vasculature Development Trabecula Morphogenesis Skeletal System Development Neuromuscular Junction Development	Extracellular Matrix Organization Extracellular Structure Organization Response To Wounding Extracellular Matrix Disassembly Wound Healing Multicellular Organismal Development Cell Adhesion Anatomical Structure Development Tissue Development Platelet Degranulation Developmental Process System Development Blood Coagulation Hemostasis Anatomical Structure Morphogenesis Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Protein Metabolic Process Regulation Of Locomotion Regulation Of Cellular Amino Acid Metabolic Process Response To Stress Regulation Of Cellular Component Movement Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Body Fluid Levels Regulation Of Cell Migration Cell-substrate Adhesion Regulation Of Epithelial Cell Migration Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Phosphorylation Endodermal Cell Differentiation Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Skeletal System Development Regulation Of Cellular Protein Metabolic Process Organ Development Blood Vessel Morphogenesis Regulation Of Phosphorus Metabolic Process Platelet Activation Organ Morphogenesis Locomotion Endoderm Formation Angiogenesis Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Exocytosis
Tagcloud ?		amplifiable analyte angpt2 aptamer c7 cdta clostridium crdl1 difficile du exponential gpvi hold lumavidin luminex multiplexed naphthylmethyl panels picomolar plg radiolabel reagents sandwich selex somamer somamers tryptaminocarbonyl tsp2 wise	archive bcl6 cancerous cebpb checked cufflinks david deg degs downloaded exph5 fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools
Tagcloud (Difference) ?		amplifiable analyte angpt2 aptamer c7 cdta clostridium crdl1 difficile du exponential gpvi hold lumavidin luminex multiplexed naphthylmethyl panels picomolar plg radiolabel reagents sandwich selex somamer somamers tryptaminocarbonyl tsp2 wise	archive bcl6 cancerous cebpb checked cufflinks david deg degs downloaded exph5 fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools
Tagcloud (Intersection) ?