MATN2 and DVL3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MATN2	DVL3
Description		matrilin 2	dishevelled segment polarity protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Matrix Matrilin Complex	Chromatin Cytoplasm Cytosol
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Protease Binding Signaling Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Small GTPase Binding
	Biological Process	Neuron Migration Axon Guidance Glial Cell Migration Extracellular Matrix Organization Dendrite Regeneration Neuron Projection Development Response To Axon Injury	Small GTPase-mediated Signal Transduction Response To Xenobiotic Stimulus Wnt Signaling Pathway Regulation Of Protein Localization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Protein Stabilization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Neuron Projection Arborization
Pathways			TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Diffusing capacity of carbon monoxide ( 30694715) Eosinophilic esophagitis ( 34506852) Erectile dysfunction ( 30583798)	Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Major depressive disorder ( 22472876) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494)
Interacting Genes		17 interacting genes: ATXN1 ATXN1L ATXN7 CACNA1A CBFA2T3 COL1A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 DVL3 FBN2 FN1 MATN1 MATN4	166 interacting genes: ABT1 ADAP1 AKAP17A ANKRD36B AP3M1 AXIN1 BAHD1 BEND7 BHLHE40 C1orf35 C8orf33 CBX8 CCDC33 CCNK CCNL1 CDYL2 CEP57L1 CEP70 CEP76 CLK1 CSNK1D CSNK1E CSNK2A1 CT45A10 CT45A3 CTNNB1 CYSRT1 DAB2 DDX54 DIDO1 DPPA2 DVL1 DYRK1A EIF1B EIF3D ENKD1 FAM13C FAM90A1 FARS2 FGF16 FLACC1 GADD45GIP1 HOMER3 HOXA5 HOXC5 HOXC8 INO80B KAT7 KAZN KCTD10 KCTD7 KLF1 KLF15 KLF3 KLF4 KLHL12 LENG8 LNX1 LONRF1 LRRK2 LUZP4 LY6H MAB21L3 MAGEB4 MAGOHB MARK2 MATN2 MBD1 NFYA NKD1 NOL12 NXF1 PATZ1 PHF19 PIK3CB PITX1 PLAGL2 PLN PNKP PPM1A PPP1R16B PPP2CA PRKAA2 PRPF18 PRPF3 PRPF31 PRPF38A PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E PSME3 PSMF1 RBM15B RBM39 RNF151 RPL11 RPS10 RRP8 RWDD2B SAP30L SHFL SNIP1 SNX22 SORBS3 STOM SUV39H1 SYT6 SYTL4 TBPL1 TCEA2 TCEANC TFG THAP7 TLE5 TNFAIP8L1 TNP1 TPTEP2-CSNK1E TRAF2 TRIM41 TRIM54 TSN TSPYL1 TSPYL6 UTP3 VANGL1 VAX1 WDR25 WT1 XPA YTHDC1 ZBTB24 ZBTB26 ZBTB47 ZBTB48 ZBTB8A ZFP57 ZNF165 ZNF2 ZNF264 ZNF319 ZNF408 ZNF417 ZNF441 ZNF444 ZNF497 ZNF512B ZNF552 ZNF581 ZNF648 ZNF696 ZNF697 ZNF699 ZNF71 ZNF764 ZNF774 ZNF775 ZNF792 ZNF821 ZNF837 ZRSR2 ZSCAN21 ZSCAN22 ZSCAN25
Entrez ID		4147	1857
HPRD ID		03660	03222
Ensembl ID		ENSG00000132561	ENSG00000161202
Uniprot IDs		A0A140VKH7 O00339 Q8N2G3	Q92997
PDB IDs			6V7O 6ZBQ 6ZBZ 6ZC3 6ZC4 6ZC6 6ZC7 6ZC8 8S6A
Enriched GO Terms of Interacting Partners?		Collagen Type IV Trimer Extracellular Matrix Structural Constituent Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Matrix Extracellular Matrix Organization Extracellular Structure Organization Collagen Trimer Basement Membrane Endoplasmic Reticulum Lumen Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Extracellular Region Enzyme-linked Receptor Protein Signaling Pathway Matrilin Complex POZ Domain Binding Bone Trabecula Formation Cell Surface Receptor Signaling Pathway Platelet-derived Growth Factor Binding Glomerular Basement Membrane Development Cellular Response To Amino Acid Stimulus Protease Binding Response To Amino Acid Endodermal Cell Differentiation Neuromuscular Junction Development DNA-templated Transcription Cellular Response To Vitamin E Anatomical Structure Formation Involved In Morphogenesis Growth Plate Cartilage Chondrocyte Morphogenesis Lung Alveolus Development Regulation Of Developmental Process Nervous System Process Social Behavior Brain Development Animal Organ Development Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Multicellular Organismal Development Collagen Type I Trimer Cellular Response To Fluoride Response To Transforming Growth Factor Beta Response To Activity Regulation Of Bone Mineralization Developmental Process Sequestering Of TGFbeta In Extracellular Matrix Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Signal Transduction Angiogenesis Response To Fluoride Calcium-independent Cell-matrix Adhesion	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process DNA Binding Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding Wnt Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Speck Cellular Response To Endothelin Response To Endothelin Negative Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Epigenetic Regulation Of Gene Expression Wnt Signalosome Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process Positive Regulation Of Non-canonical Wnt Signaling Pathway DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm RNA Metabolic Process Chromatin Organization Nucleic Acid Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Sequence-specific Double-stranded DNA Binding Heterochromatin Formation Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Chromatin Remodeling U2-type Precatalytic Spliceosome Chromatin Silencing Complex Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
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