MATN2 and COL4A6

Number of citations of the paper that reports this interaction (PubMedID 12180907)
23

Data Source:
HPRD (in vivo)

		MATN2	COL4A6
Description		matrilin 2	collagen type IV alpha 6 chain
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Matrix Matrilin Complex	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Neuron Migration Axon Guidance Glial Cell Migration Extracellular Matrix Organization Dendrite Regeneration Neuron Projection Development Response To Axon Injury	Cell Adhesion Extracellular Matrix Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Cellular Response To Amino Acid Stimulus
Pathways			Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Collagen chain trimerization Attachment of bacteria to epithelial cells
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Diffusing capacity of carbon monoxide ( 30694715) Eosinophilic esophagitis ( 34506852) Erectile dysfunction ( 30583798)	Electrodermal activity ( 25387706)
Interacting Genes		17 interacting genes: ATXN1 ATXN1L ATXN7 CACNA1A CBFA2T3 COL1A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 DVL3 FBN2 FN1 MATN1 MATN4	12 interacting genes: APP CD93 DCN FBLN2 FN1 HABP2 MAGEA6 MATN2 MMP9 NOTCH1 OSM SERPINE2
Entrez ID		4147	1288
HPRD ID		03660	02364
Ensembl ID		ENSG00000132561	ENSG00000197565
Uniprot IDs		A0A140VKH7 O00339 Q8N2G3	A0A087WZY5 A8MXH5 A8VPY0 B2RTX6 B7ZMM7 F5H3Q5 Q14031
PDB IDs
Enriched GO Terms of Interacting Partners?		Collagen Type IV Trimer Extracellular Matrix Structural Constituent Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Matrix Extracellular Matrix Organization Extracellular Structure Organization Collagen Trimer Basement Membrane Endoplasmic Reticulum Lumen Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Extracellular Region Enzyme-linked Receptor Protein Signaling Pathway Matrilin Complex POZ Domain Binding Bone Trabecula Formation Cell Surface Receptor Signaling Pathway Platelet-derived Growth Factor Binding Glomerular Basement Membrane Development Cellular Response To Amino Acid Stimulus Protease Binding Response To Amino Acid Endodermal Cell Differentiation Neuromuscular Junction Development DNA-templated Transcription Cellular Response To Vitamin E Anatomical Structure Formation Involved In Morphogenesis Growth Plate Cartilage Chondrocyte Morphogenesis Lung Alveolus Development Regulation Of Developmental Process Nervous System Process Social Behavior Brain Development Animal Organ Development Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Multicellular Organismal Development Collagen Type I Trimer Cellular Response To Fluoride Response To Transforming Growth Factor Beta Response To Activity Regulation Of Bone Mineralization Developmental Process Sequestering Of TGFbeta In Extracellular Matrix Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Signal Transduction Angiogenesis Response To Fluoride Calcium-independent Cell-matrix Adhesion	Extracellular Region Extracellular Matrix Glycosaminoglycan Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptidase Activator Activity Extracellular Space Regulation Of Cell Migration Regulation Of Locomotion Regulation Of Cell Motility Calcium Ion Binding Regulation Of Development, Heterochronic Positive Regulation Of Astrocyte Differentiation Regulation Of Timing Of Cell Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Matrix Structural Constituent Platelet Alpha Granule Signaling Receptor Binding Regulation Of Intracellular Signal Transduction Heparin Binding Negative Regulation Of Transport Extracellular Matrix Binding Regulation Of Astrocyte Differentiation Negative Regulation Of Signaling Negative Regulation Of Cell Communication Endodermal Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Glial Cell Differentiation Amyloid-beta Complex Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Regulation Of Growth Regulation Of Developmental Process Regulation Of Response To Calcium Ion Regulation Of Cell Population Proliferation Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Extracellular Matrix Organization Positive Regulation Of Signal Transduction Dendrite Development Extracellular Structure Organization Regulation Of Cell-substrate Adhesion Positive Regulation Of Neurogenesis Response To Wounding Negative Regulation Of Epithelial Cell Differentiation
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