HIST2H3C and COPRS

Number of citations of the paper that reports this interaction (PMID 18404153)
25

Data Source:
BioGRID (pull down)

		HIST2H3C	COPRS
Gene Name		histone cluster 2, H3c	coordinator of PRMT5, differentiation stimulator
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Plasma Membrane
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Protein Binding Histone Binding
	Biological Process	Chromatin Silencing At RDNA Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Muscle Organ Development Histone H4-R3 Methylation
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS
Protein-Protein Interactions		61 interactors: ARID4A ATRX AURKB BIRC5 BRD1 BRD4 BRD7 BRPF1 CDCA8 CDK8 CHUK COPRS DDB2 DNMT3L EHMT2 ELP3 EP300 HDGFRP2 INCENP ING1 JADE1 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3A KDM4C KDM6A KMT2A KMT2B KMT2C KMT2D MSL2 MUM1 NAP1L4 NASP NCOA6 NRD1 PHF21A PIM1 PKN1 PRMT6 PTMA RBBP4 RBBP5 RERE RNF20 RNF4 RPS6KA5 SETD1A SETD1B SETD7 SMARCA4 SMYD2 STAT6 TBL1X UHRF1 VRK1 WHSC1	8 interactors: CBFB HIST1H2BC HIST2H2AC HIST2H3C HIST4H4 PRMT5 RUNX1 WDR77
Entrez ID		126961	55352
HPRD ID		11822	13675
Ensembl ID			ENSG00000172301
Uniprot IDs		Q71DI3	H9KV77 Q9NQ92
PDB IDs		2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization Histone Modification Chromosome Organization Peptidyl-lysine Modification Organelle Organization Peptidyl-amino Acid Modification Transcription, DNA-templated RNA Biosynthetic Process Cellular Protein Modification Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Histone Methylation Gene Expression Peptidyl-lysine Methylation Methylation Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Protein Methylation Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone Lysine Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Protein Metabolic Process Histone H3 Acetylation Positive Regulation Of Cellular Biosynthetic Process Histone H3-K4 Methylation Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression	DNA Methylation On Cytosine Chromatin Silencing At RDNA Definitive Hemopoiesis Cellular Macromolecular Complex Assembly Chromatin Organization Chromatin Silencing Spliceosomal SnRNP Assembly DNA Methylation Chromosome Organization Gene Expression Methylation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Myeloid Cell Differentiation DNA Modification Gene Silencing Positive Regulation Of Progesterone Secretion Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Regulation Of Transcription, DNA-templated Nucleosome Assembly Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Assembly Histone H4-K20 Demethylation Regulation Of Progesterone Secretion Nucleosome Organization Nucleobase-containing Compound Metabolic Process Chromatin Assembly Or Disassembly Heterocycle Metabolic Process Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Regulation Of Hair Follicle Cell Proliferation Cellular Aromatic Compound Metabolic Process Protein-DNA Complex Assembly Ribonucleoprotein Complex Assembly Regulation Of Gene Expression Regulation Of Myeloid Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Megakaryocyte Differentiation DNA Packaging Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic Cellular Component Assembly Negative Regulation Of Granulocyte Differentiation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Myeloid Progenitor Cell Differentiation Positive Regulation Of Granulocyte Differentiation Nitrogen Compound Metabolic Process Myeloid Cell Differentiation
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