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ATRX and DAXX
Number of citations of the paper that reports this interaction (PubMedID
12953102
)
45
Data Source:
HPRD
(in vitro)
ATRX
DAXX
Description
ATRX chromatin remodeler
death domain associated protein
Image
GO Annotations
Cellular Component
Nuclear Chromosome
Condensed Chromosome, Centromeric Region
Chromosome, Telomeric Region
Heterochromatin
Nucleus
Nucleoplasm
Chromosome
Pericentric Heterochromatin
Nuclear Body
PML Body
Chromosome, Subtelomeric Region
Chromosome, Centromeric Region
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Cytosol
Nuclear Body
PML Body
Molecular Function
Nucleotide Binding
DNA Binding
Chromatin Binding
Helicase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
DNA Translocase Activity
Hydrolase Activity
ATP Hydrolysis Activity
Chromatin DNA Binding
Histone Binding
Metal Ion Binding
Histone H3K9me2/3 Reader Activity
Chromo Shadow Domain Binding
P53 Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Enzyme Binding
Protein Kinase Binding
Protein Kinase Activator Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Histone Binding
Protein Homodimerization Activity
Nuclear Androgen Receptor Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Transcription Regulator Inhibitor Activity
Molecular Condensate Scaffold Activity
Biological Process
Meiotic Spindle Organization
DNA Repair
Chromatin Organization
Nucleosome Assembly
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Transcription By RNA Polymerase II
DNA Damage Response
Spermatogenesis
Regulation Of Cell Cycle Process
Positive Regulation Of Nuclear Cell Cycle DNA Replication
DNA Damage Response, Signal Transduction By P53 Class Mediator
Forebrain Development
Replication Fork Processing
Subtelomeric Heterochromatin Formation
Positive Regulation Of Telomere Maintenance
Regulation Of Chromosome Organization
Post-embryonic Forelimb Morphogenesis
Multicellular Organism Growth
Positive Regulation Of Transcription By RNA Polymerase II
Sertoli Cell Development
Chromosome Organization Involved In Meiotic Cell Cycle
Protein Localization To Chromosome, Telomeric Region
Seminiferous Tubule Development
Cellular Response To Hydroxyurea
Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric
Chromatin Organization
Nucleosome Assembly
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Apoptotic Process
JNK Cascade
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Androgen Receptor Signaling Pathway
Regulation Of Protein Ubiquitination
Cellular Response To Heat
Cellular Response To Unfolded Protein
Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Regulation Of Apoptotic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Cellular Response To Cadmium Ion
Cellular Response To Copper Ion
Cellular Response To Diamide
Cellular Response To Sodium Arsenite
Pathways
Inhibition of DNA recombination at telomere
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations
SUMOylation of transcription cofactors
Regulation of TP53 Degradation
HCMV Early Events
Inhibition of DNA recombination at telomere
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations
Drugs
Diseases
Non-syndromic X-linked mental retardation
Thalassemia; Alpha thalassemia; Beta thalassemia; Alpha thalassemia, X-linked (ATRX)
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Adult body size (
32376654
)
Autism spectrum disorder or schizophrenia (
28540026
)
Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) (
30120083
)
Lung cancer (
28604730
)
Lung cancer in ever smokers (
28604730
)
Interacting Genes
33 interacting genes:
ATN1
AURKA
BLM
BRD9
CALM1
CBS
CCSER2
CEP126
CLIC6
CREBBP
DAXX
DSCAM
EZH2
H3C14
HDAC1
HDAC4
LUC7L2
MDM2
NEK1
NSD1
PTN
PTPN4
RAD51
RAD51AP1
RASSF1
RBM11
SLX9
SUMO2
SVIL
WRN
ZBED1
ZMYND8
ZNF512B
114 interacting genes:
ACVR2A
AIRE
AMOTL2
AR
ATM
ATRX
BTBD6
CA12
CALCOCO2
CARD9
CARM1
CBS
CDCA7L
CENPC
CEP63
CEP70
CFLAR
CREBBP
CSNK2A1
CSNK2B
DAPK3
DKC1
DMAP1
DNMT1
DRC4
ESRRG
ETS1
FAM9B
FANCA
FAS
FASLG
FTH1
GOLGA2
GOLGA6L9
GRIPAP1
H3-3B
H3-5
H3C3
H4C16
HABP4
HBA1
HDAC1
HDAC2
HDAC3
HIPK1
HIPK2
HIPK3
HSF1
HSF4
HSPB1
KCTD4
MAP3K5
MCRS1
MDM2
MEN1
MIPOL1
MKRN1
MSANTD4
MX1
MYH11
NECAB2
NSD3
PARK7
PAX3
PAX5
PBXIP1
PIBF1
PLAGL1
PML
PNMA1
PRMT1
PTEN
RASSF1
RASSF3
RIPK3
RNF4
RPL13
SENP2
SERBP1
SLC2A4
SLC9A1
SNW1
SPN
SPOP
SQSTM1
SSX2IP
STAT3
STK4
STUB1
SUMO1
SUMO2
SUMO3
TAX1BP1
TCF3
TCF4
TCF7L2
TFIP11
TGFB1
TGFBR2
TNFRSF1A
TP53
TP63
TP73
TRAF3
TRIM21
TRIM54
TSG101
UBC
UBE2I
USH1G
USP7
WEE2-AS1
ZBTB2
ZBTB26
Entrez ID
546
1616
HPRD ID
02069
04424
Ensembl ID
ENSG00000085224
ENSG00000204209
Uniprot IDs
A4LAA3
B4DLW1
P46100
A0A024RCS3
B4E1C1
Q53F85
Q9UER7
PDB IDs
2JM1
2LBM
2LD1
3QL9
3QLA
3QLC
3QLN
4W5A
5GRQ
5Y18
5Y6O
6G0O
2KQS
2KZS
2KZU
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
5GRQ
5KDM
5Y18
5Y6O
Enriched GO Terms of Interacting Partners
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Nucleoplasm
SUMO Transferase Activity
Recombinational Repair
P53 Binding
Double-strand Break Repair Via Homologous Recombination
Cellular Response To Ionizing Radiation
Transcription Corepressor Activity
Nucleus
Cellular Response To Radiation
PML Body
Forked DNA-dependent Helicase Activity
Chromatin Remodeling
Chromatin Organization
Protein Sumoylation
Chromatin
Double-strand Break Repair
Cellular Response To Stress
Chromosome
DNA Recombination
Response To Ionizing Radiation
Regulation Of Cell Cycle Process
8-hydroxy-2'-deoxyguanosine DNA Binding
Telomeric G-quadruplex DNA Binding
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Division
Telomeric D-loop Binding
Y-form DNA Binding
Chromosome, Telomeric Region
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cellular Response To Gamma Radiation
Centrosome
Cellular Response To Camptothecin
Cellular Response To Alkaloid
Negative Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Four-way Junction Helicase Activity
Response To Glycoside
Replication Fork Processing
Telomere Maintenance Via Semi-conservative Replication
Negative Regulation Of Striated Muscle Cell Differentiation
Pronucleus
Positive Regulation Of Metabolic Process
DNA Geometric Change
Bubble DNA Binding
Positive Regulation Of Macromolecule Metabolic Process
DNA Damage Response
Enzyme Binding
PML Body
Identical Protein Binding
Nucleus
Nucleoplasm
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Stress
Positive Regulation Of Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
DNA Damage Response
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Regulation Of Programmed Cell Death
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Apoptotic Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Apoptotic Process
Regulation Of Protein Metabolic Process
PML Body Organization
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Nuclear Body
Regulation Of Gene Expression
Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Intracellular Signal Transduction
Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Regulation Of Signaling
Positive Regulation Of Programmed Cell Death
Regulation Of Cell Communication
Positive Regulation Of Intracellular Signal Transduction
Programmed Cell Death
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