KMT2A and MTM1

Number of citations of the paper that reports this interaction (PubMedID 9537414)
0

Data Source:
BioGRID (pull down)

		KMT2A	MTM1
Description		lysine methyltransferase 2A	myotubularin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Histone Methyltransferase Complex MLL1/2 Complex MLL1 Complex	Ruffle Cytoplasm Endosome Late Endosome Cytosol Plasma Membrane Membrane Sarcomere Filopodium I Band Cell Projection
	Molecular Function	DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone H3K4 Methyltransferase Activity Identical Protein Binding Protein Homodimerization Activity Unmethylated CpG Binding Metal Ion Binding Protein-cysteine Methyltransferase Activity Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity	Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphoprotein Phosphatase Activity Protein Binding Hydrolase Activity Intermediate Filament Binding Phosphatidylinositol Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity
	Biological Process	Immune System Process Chromatin Organization Regulation Of DNA-templated Transcription Apoptotic Process Visual Learning Response To Light Stimulus Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Methylation Circadian Regulation Of Gene Expression Embryonic Hemopoiesis Exploration Behavior Response To Potassium Ion Protein Modification Process Epigenetic Regulation Of Gene Expression T-helper 2 Cell Differentiation Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Regulation Of Short-term Neuronal Synaptic Plasticity Rhythmic Process Spleen Development Homeostasis Of Number Of Cells Within A Tissue Cognition Membrane Depolarization Definitive Hemopoiesis Protein-containing Complex Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation	Autophagosome Assembly Protein Dephosphorylation Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Mitochondrion Organization Endosome To Lysosome Transport Protein Transport TOR Signaling Negative Regulation Of TOR Signaling Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Vacuole Organization Intermediate Filament Organization Muscle Cell Cellular Homeostasis Phosphatidylinositol Dephosphorylation Mitochondrion Distribution Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Autophagosome Assembly
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Formation of WDR5-containing histone-modifying complexes Regulation of PD-L1(CD274) transcription Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)	Centronuclear myopathy
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Metabolic syndrome ( 31589552) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		33 interacting genes: ASH2L AVP BMI1 CBX4 CREBBP CTNNB1 FASLG H2AC4 H2BC3 H3-3A H3C1 H3C14 HCFC1 HCFC2 INS KAT8 MEN1 MTM1 OXT PAF1 PLXNB1 PPIE PPP1R15A PSIP1 RBBP5 RBM39 RNF2 SBF1 SET SVIL TAF9 TASP1 WDR5	3 interacting genes: BTG3 KMT2A MTMR12
Entrez ID		4297	4534
HPRD ID		01162	02331
Ensembl ID		ENSG00000118058	ENSG00000171100
Uniprot IDs		A0AA34QVI8 E9PR05 Q03164	A0A8I5KQR6 A0A8I5KZ76 Q13496
PDB IDs		2AGH 2J2S 2JYI 2KKF 2KU7 2KYU 2LXS 2LXT 2MSR 2MTN 2W5Y 2W5Z 3EG6 3EMH 3LQH 3LQI 3LQJ 3P4F 3U85 3U88 4ESG 4GQ6 4NW3 5F5E 5F6L 5SVH 6EMQ 6KIU 6KIV 6KIX 6KIZ 6PWV 6PWW 6U9K 6U9M 6U9N 6U9R 6W5I 6W5M 6W5N 7MBM 7MBN 7RZD 7RZJ 7S79 7S7D 7S8A 7S8E 7S8F 7U5V 7W67 7W6A 7W6I 7W6J 7ZEY 7ZEZ
Enriched GO Terms of Interacting Partners?		MLL1 Complex Chromatin Remodeling MLL1/2 Complex Chromatin Organization Histone Methyltransferase Complex Set1C/COMPASS Complex Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process Histone Acetyltransferase Complex NSL Complex Structural Constituent Of Chromatin Negative Regulation Of DNA-templated Transcription Nucleoplasm MLL3/4 Complex Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Neurohypophyseal Hormone Activity DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Transcription Coactivator Activity Nucleosome Assembly Protein-DNA Complex Assembly PRC1 Complex Nucleosome Euchromatin RING-like Zinc Finger Domain Binding Nucleosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Heterodimerization Activity Maternal Aggressive Behavior Positive Regulation Of Macromolecule Biosynthetic Process PcG Protein Complex Positive Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Histone Acetyltransferase Activity Positive Regulation Of Metabolic Process Cell Development Regulation Of Cell Cycle	T-helper 2 Cell Differentiation Unmethylated CpG Binding Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity MLL1/2 Complex Negative Regulation Of Heterochromatin Formation Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Minor Groove Of Adenine-thymine-rich DNA Binding Regulation Of Heterochromatin Formation Histone H3K4 Methyltransferase Activity Regulation Of Short-term Neuronal Synaptic Plasticity Definitive Hemopoiesis Response To Potassium Ion Embryonic Hemopoiesis Regulation Of Chromatin Organization Spleen Development Negative Regulation Of Cell Population Proliferation T-helper Cell Differentiation Histone Methyltransferase Complex MLL1 Complex Exploration Behavior Homeostasis Of Number Of Cells Within A Tissue Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation T Cell Differentiation Involved In Immune Response Positive Regulation Of Gene Expression, Epigenetic Visual Learning Transcription Initiation-coupled Chromatin Remodeling CD4-positive, Alpha-beta T Cell Differentiation Membrane Depolarization Visual Behavior Regulation Of Neuronal Synaptic Plasticity CD4-positive, Alpha-beta T Cell Activation Cellular Response To Transforming Growth Factor Beta Stimulus Sarcomere Circadian Regulation Of Gene Expression Alpha-beta T Cell Differentiation Sarcoplasmic Reticulum T Cell Activation Involved In Immune Response Response To Transforming Growth Factor Beta
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