KMT2A and RBBP5

Number of citations of the paper that reports this interaction (PMID 15199122)
194

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		KMT2A	RBBP5
Gene Name		lysine (K)-specific methyltransferase 2A	retinoblastoma binding protein 5
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Histone Methyltransferase Complex MLL1 Complex	Nucleus Nucleoplasm Nucleolus Histone Methyltransferase Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	Core Promoter Sequence-specific DNA Binding AT DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Identical Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Unmethylated CpG Binding Lysine-acetylated Histone Binding	Protein Binding Methylated Histone Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding
	Biological Process	DNA Methylation Chromatin Organization Transcription From RNA Polymerase II Promoter Protein Complex Assembly Apoptotic Process Negative Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Positive Regulation Of Transporter Activity Circadian Regulation Of Gene Expression Embryonic Hemopoiesis Histone H4-K16 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H3-K14 Acetylation Histone H3-K4 Trimethylation Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Cellular Response To Drug	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Response To Estrogen Histone H3-K4 Methylation
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Signaling by Wnt deactivation of the beta-catenin transactivating complex Chromatin modifying enzymes TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ASH2L AVP BMI1 CBX4 CREBBP CTNNB1 CTR9 FASLG H3F3A HCFC1 HCFC2 HIST1H3A HIST1H4A HIST2H3C HIST3H3 INS KAT8 MEN1 MTM1 OXT PAF1 PLXNB1 PPIE PPP1R15A RBBP5 RNF2 SBF1 SET SVIL TAF9 TASP1 TOP1 WDR5	10 interactors: CHD8 CTBP1 CTNNB1 HIST2H3C HIST3H3 KMT2A MEN1 RB1 TP53 UBE2I
Entrez ID		4297	5929
HPRD ID		01162	02826
Ensembl ID		ENSG00000118058	ENSG00000117222
Uniprot IDs		Q03164	B4DLF8 Q15291
PDB IDs		2AGH 2J2S 2JYI 2KKF 2KU7 2KYU 2LXS 2LXT 2W5Y 2W5Z 3EG6 3EMH 3LQH 3LQI 3LQJ 3P4F 3U85 3U88 4ESG 4GQ6	3P4F
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Peptidyl-lysine Modification Regulation Of Gene Expression Organelle Organization Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Gene Expression Methylation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Peptidyl-amino Acid Modification Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Positive Regulation Of Cellular Biosynthetic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Nitrogen Compound Metabolic Process DNA Methylation Protein Acetylation Cellular Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Histone H3-K4 Methylation DNA Modification Histone Ubiquitination Chromatin Silencing	Positive Regulation Of Histone Modification Regulation Of Chromosome Organization Negative Regulation Of Transcription, DNA-templated Regulation Of Histone Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Positive Regulation Of Organelle Organization Chromosome Organization Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Organelle Organization Chromatin Organization Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Histone Methylation Regulation Of Organelle Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Histone Methylation Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Modification Regulation Of RNA Metabolic Process Hemopoiesis Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Glial Cell Apoptotic Process Heterocycle Metabolic Process Immune System Development Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Sister Chromatid Cohesion Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Histone H3-K4 Methylation
Tagcloud ?		alters associates demethylase h3k4 h3k4me3 hmt hyperplastic igf2bp2 integrative interactive islet islets jarid1 jumonji kdm5a kmt2b landscape men1 menin methyltransferases mll1 mll4 neuroendocrine pancreatic pannets rbp2 seq trimethylation unbiased	acidic allosterically ash2l box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 mutational referred ryanodine set1 spia spry stimulates switch trithorax trxg wdr5 wrad
Tagcloud (Difference) ?		alters associates demethylase h3k4 h3k4me3 hmt hyperplastic igf2bp2 integrative interactive islet islets jarid1 jumonji kdm5a kmt2b landscape men1 menin mll4 neuroendocrine pancreatic pannets rbp2 seq trimethylation unbiased	acidic allosterically ash2l box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferase mutational referred ryanodine set1 spia spry stimulates switch trithorax trxg wdr5 wrad
Tagcloud (Intersection) ?		methyltransferases mll1