KMT2A and TAF9

Number of citations of the paper that reports this interaction (PMID 10821850)
12

Data Source:
HPRD (in vitro)

		KMT2A	TAF9
Gene Name		lysine (K)-specific methyltransferase 2A	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Histone Methyltransferase Complex MLL1 Complex	PCAF Complex Nucleoplasm Transcription Factor TFIID Complex STAGA Complex Transcription Factor TFTC Complex Pre-snoRNP Complex MLL1 Complex
	Molecular Function	Core Promoter Sequence-specific DNA Binding AT DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Identical Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Unmethylated CpG Binding Lysine-acetylated Histone Binding	P53 Binding DNA Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Activating Transcription Factor Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity C2H2 Zinc Finger Domain Binding
	Biological Process	DNA Methylation Chromatin Organization Transcription From RNA Polymerase II Promoter Protein Complex Assembly Apoptotic Process Negative Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Positive Regulation Of Transporter Activity Circadian Regulation Of Gene Expression Embryonic Hemopoiesis Histone H4-K16 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H3-K14 Acetylation Histone H3-K4 Trimethylation Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Cellular Response To Drug	Chromatin Organization Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Gene Expression Viral Process Positive Regulation Of Cell Growth Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Histone H3 Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Stabilization Positive Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Chromatin organization HIV Infection HATs acetylate histones RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle HIV Life Cycle HIV Transcription Initiation Chromatin modifying enzymes RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase II HIV Promoter Escape RNA Polymerase II Transcription Initiation Transcription of the HIV genome
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ASH2L AVP BMI1 CBX4 CREBBP CTNNB1 CTR9 FASLG H3F3A HCFC1 HCFC2 HIST1H3A HIST1H4A HIST2H3C HIST3H3 INS KAT8 MEN1 MTM1 OXT PAF1 PLXNB1 PPIE PPP1R15A RBBP5 RNF2 SBF1 SET SVIL TAF9 TASP1 TOP1 WDR5	53 interactors: AHR ALL1 ANK2 APP CEBPB CIITA COIL DRAP1 EEF1A1 ELF3 FBL FBLN1 FEZ1 GALNT6 GTF2B HCFC1 HIST3H3 HNF4A HSF1 KLF6 KMT2A KPNA1 KPNA6 LAMTOR5 MYC NCOA2 NCOR1 NDRG1 NFATC2 NR1D2 NUFIP1 RBM48 RELA RNF138 RPS14 RPS24 RUVBL1 RUVBL2 SF3B3 TAF1 TAF10 TAF11 TAF12 TAF2 TAF4 TAF5 TAF6 TAF6L TAF7 TAF8 TBCA TP53 UBA1
Entrez ID		4297	6880
HPRD ID		01162	15983
Ensembl ID		ENSG00000118058	ENSG00000085231
Uniprot IDs		Q03164	Q16594
PDB IDs		2AGH 2J2S 2JYI 2KKF 2KU7 2KYU 2LXS 2LXT 2W5Y 2W5Z 3EG6 3EMH 3LQH 3LQI 3LQJ 3P4F 3U85 3U88 4ESG 4GQ6
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Peptidyl-lysine Modification Regulation Of Gene Expression Organelle Organization Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Gene Expression Methylation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Peptidyl-amino Acid Modification Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Positive Regulation Of Cellular Biosynthetic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Nitrogen Compound Metabolic Process DNA Methylation Protein Acetylation Cellular Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Histone H3-K4 Methylation DNA Modification Histone Ubiquitination Chromatin Silencing	RNA Metabolic Process RNA Biosynthetic Process Gene Expression Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Histone Acetylation Biosynthetic Process Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process DNA-templated Transcription, Elongation Positive Regulation Of Metabolic Process Cellular Metabolic Process Peptidyl-lysine Modification Chromatin Organization Chromatin Modification Histone Modification Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process
Tagcloud ?		alters associates demethylase h3k4 h3k4me3 hmt hyperplastic igf2bp2 integrative interactive islet islets jarid1 jumonji kdm5a kmt2b landscape men1 menin methyltransferases mll1 mll4 neuroendocrine pancreatic pannets rbp2 seq trimethylation unbiased	acetyltransferase associates box coactivators contacted crosslinking dimerization gcn5 hat hence homology interacting m2 m3 macromolecular max mbi moderately motifs myc partner spt3 staga sub substitutions tad tert transactivation trrap
Tagcloud (Difference) ?		alters demethylase h3k4 h3k4me3 hmt hyperplastic igf2bp2 integrative interactive islet islets jarid1 jumonji kdm5a kmt2b landscape men1 menin methyltransferases mll1 mll4 neuroendocrine pancreatic pannets rbp2 seq trimethylation unbiased	acetyltransferase box coactivators contacted crosslinking dimerization gcn5 hat hence homology interacting m2 m3 macromolecular max mbi moderately motifs myc partner spt3 staga sub substitutions tad tert transactivation trrap
Tagcloud (Intersection) ?		associates