HEXIM2 and ADAMTSL4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HEXIM2	ADAMTSL4
Description		HEXIM P-TEFb complex subunit 2	ADAMTS like 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Extracellular Region Interstitial Matrix Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding	Protease Binding Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription	Epithelial Cell Development Apoptotic Process Extracellular Matrix Organization Positive Regulation Of Apoptotic Process Pigment Cell Development
Pathways			Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs
Diseases			Ectopia lentis
GWAS		Asthma ( 31619474 31959851) Brain morphology (MOSTest) ( 32665545) Craniofacial microsomia ( 26853712) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)	Appendicular lean mass ( 33097823) Asthma ( 32296059) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Migraine ( 27322543) Refractive error ( 32231278) Rhegmatogenous retinal detachment ( 23585552) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		47 interacting genes: ADAMTSL4 AP2M1 CACNB2 CCDC33 CCNT1 CDK9 CFP CTIF DBF4B DRC4 EGFL7 FAM161A GATA1 HEXIM1 HOXA1 HSF2BP IHO1 KPNA3 KPRP KRTAP13-3 LNX1 MEOX2 PICK1 PIM1 PIN1 PRDM14 PSMA1 RNPS1 SAXO1 SDCBP SPRED1 SPRY1 SPRY2 TADA3 TERF1 TERF2 TLE5 TNFAIP1 TRIM14 YPEL3 ZNF250 ZNF426 ZNF500 ZNF558 ZNF655 ZNF699 ZNF789	212 interacting genes: ADAM12 ADAMTSL5 ALPP AMMECR1 APOL6 AQP1 ARNT2 ASPSCR1 ATG9A BAG4 BANF2 BOLA2 BOLA2B BRME1 CATSPER1 CBX3 CCDC26 CFAP206 CHCHD2 CHERP CHIC2 CHRD CHRNG CLEC18A COL8A1 CPNE7 CREB5 CST2 CTSB CXCL16 CYP2S1 CYSRT1 DGCR6 DGCR6L DIP2A DLK2 DNPEP DSCR8 EFEMP2 EIF4E2 EPDR1 ERCC3 EXOSC5 FAH FAM124B FARS2 FBLN1 FBXL9P FBXO17 FBXW5 FHL3 FKBP1B FLNA FRS3 FXR1 GATA2 GIP GLRX3 GLYCTK GMCL2 GNE GNG13 GNMT GOLGA8EP GSTP1 GUCD1 HEXIM2 HGF HNRNPLL HOXA1 HOXC8 HSD3B7 INS IP6K1 ITGB2 ITGB4 JOSD1 KCTD7 KCTD9 KIF1A KLHL38 KRTAP1-1 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP19-2 KRTAP21-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LGALS14 LHX4 LINC00671 LMO1 LMO2 LMO4 LNX1 LONRF1 LRFN4 MAGOHB MAPKBP1 MGAT5B MID2 MKRN3 MORN3 MVP MYLIP MYO15B NATD1 NBPF19 NEK8 NFKBID NMUR2 NOTCH2NLA NR4A3 NTAQ1 NTF4 NTN4 NUFIP2 OLFM3 OTX1 PCSK5 PID1 PIN1 PKN1 PLSCR1 PLSCR4 POLD1 POLR1C POU4F2 PRKAB2 PRR19 PTGER3 PTPMT1 QPRT R3HDM2 RAB2B RCHY1 RGL2 RHOJ RPS19BP1 RUNX1T1 SALL2 SCNM1 SHFL SLC13A5 SLC23A1 SLC6A20 SLIT1 SMARCC1 SORBS3 SPATA8 SPINK2 SPRY1 SPRY2 STK16 SUSD6 TAPBPL TCEA2 TFAP2D TGFB1 THAP6 TMEM150A TMSB4XP6 TOP3B TRIM42 TRIM55 TRIM63 TRIP6 TSSK3 TUBGCP4 USP21 VASN VENTX VWC2 ZFHX2 ZNF330 ZNF414 ZNF417 ZNF587
Entrez ID		124790	54507
HPRD ID		08129	18237
Ensembl ID		ENSG00000168517	ENSG00000143382
Uniprot IDs		Q96MH2	A0A669KBE7 B7ZMJ3 Q6UY14
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Lens Fiber Cell Differentiation 7SK SnRNA Binding Regulation Of Lens Fiber Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process P-TEFb Complex SnRNA Binding Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Shelterin Complex Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Telomerase Activity Bud Elongation Involved In Lung Branching Protein Binding Nucleus Cyclin/CDK Positive Transcription Elongation Factor Complex Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Epithelial To Mesenchymal Transition Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Negative Regulation Of Epithelial To Mesenchymal Transition DNA Binding Regulation Of Cellular Response To Growth Factor Stimulus G-rich Strand Telomeric DNA Binding Negative Regulation Of Epithelial Cell Differentiation Telomeric Loop Disassembly Regulation Of Neurotrophin TRK Receptor Signaling Pathway Telomere Capping Regulation Of Cell Cycle Branch Elongation Of An Epithelium DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Viral Transcription Protein Serine/threonine Kinase Activator Activity Host-mediated Activation Of Viral Transcription Axis Elongation Regulation Of Receptor Internalization Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Intermediate Filament Keratinization Keratin Filament Epidermis Development Protein Binding Tissue Development Identical Protein Binding Hair Cycle
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