HEXIM2 and CCNT1

Number of citations of the paper that reports this interaction (PubMedID 15994294)
0

Data Source:
HPRD (two hybrid)

		HEXIM2	CCNT1
Description		HEXIM P-TEFb complex subunit 2	cyclin T1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Nucleus Nucleoplasm Nucleolus Cytosol Cyclin/CDK Positive Transcription Elongation Factor Complex P-TEFb Complex
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity SnRNA Binding Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity RNA Polymerase Binding 7SK SnRNA Binding DNA-binding Transcription Factor Binding Molecular Condensate Scaffold Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Response To Xenobiotic Stimulus Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Host-mediated Activation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Division
Pathways			Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Asthma ( 31619474 31959851) Brain morphology (MOSTest) ( 32665545) Craniofacial microsomia ( 26853712) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)	Clozapine-induced agranulocytosis ( 25187353)
Interacting Genes		47 interacting genes: ADAMTSL4 AP2M1 CACNB2 CCDC33 CCNT1 CDK9 CFP CTIF DBF4B DRC4 EGFL7 FAM161A GATA1 HEXIM1 HOXA1 HSF2BP IHO1 KPNA3 KPRP KRTAP13-3 LNX1 MEOX2 PICK1 PIM1 PIN1 PRDM14 PSMA1 RNPS1 SAXO1 SDCBP SPRED1 SPRY1 SPRY2 TADA3 TERF1 TERF2 TLE5 TNFAIP1 TRIM14 YPEL3 ZNF250 ZNF426 ZNF500 ZNF558 ZNF655 ZNF699 ZNF789	24 interacting genes: AFF4 AHR BRD4 CDK9 ESR1 GRIPAP1 GRN GTF2F1 HEXIM1 HEXIM2 HIC2 HTATSF1 HTN1 KAT2B MDFIC MYC NCOA2 NUFIP1 PML POLR2A PRKCI PURA RN7SK SKP2
Entrez ID		124790	904
HPRD ID		08129	03938
Ensembl ID		ENSG00000168517	ENSG00000129315
Uniprot IDs		Q96MH2	A8K4M5 O60563
PDB IDs			2PK2 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z 6CYT 6GZH 6W9E 6Z45 7NWK 8I0L 8K5R
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Lens Fiber Cell Differentiation 7SK SnRNA Binding Regulation Of Lens Fiber Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process P-TEFb Complex SnRNA Binding Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Shelterin Complex Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Telomerase Activity Bud Elongation Involved In Lung Branching Protein Binding Nucleus Cyclin/CDK Positive Transcription Elongation Factor Complex Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Epithelial To Mesenchymal Transition Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Negative Regulation Of Epithelial To Mesenchymal Transition DNA Binding Regulation Of Cellular Response To Growth Factor Stimulus G-rich Strand Telomeric DNA Binding Negative Regulation Of Epithelial Cell Differentiation Telomeric Loop Disassembly Regulation Of Neurotrophin TRK Receptor Signaling Pathway Telomere Capping Regulation Of Cell Cycle Branch Elongation Of An Epithelium DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Viral Transcription Protein Serine/threonine Kinase Activator Activity Host-mediated Activation Of Viral Transcription Axis Elongation Regulation Of Receptor Internalization Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression 7SK SnRNA Binding Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Elongation SnRNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Transcription Elongation Factor Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process P-TEFb Complex Binding 7SK SnRNP Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction By P53 Class Mediator DNA-templated Transcription Rhythmic Process Transcription Regulator Inhibitor Activity Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Transcription Coactivator Binding Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Elongation Protein-containing Complex Positive Regulation Of Fibroblast Proliferation
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