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HEXIM2 and CDK9
Number of citations of the paper that reports this interaction (PMID
15713662
)
43
Data Source:
HPRD
(in vivo, in vitro)
HEXIM2
CDK9
Gene Name
hexamethylene bis-acetamide inducible 2
cyclin-dependent kinase 9
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Nucleoplasm
Cytoplasm
Transcription Elongation Factor Complex
Positive Transcription Elongation Factor Complex B
Membrane
PML Body
Intracellular Membrane-bounded Organelle
Molecular Function
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
SnRNA Binding
DNA Binding
Chromatin Binding
Protein Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II Carboxy-terminal Domain Kinase Activity
SnRNA Binding
Transcription Regulatory Region DNA Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription, DNA-templated
DNA Repair
Regulation Of DNA Repair
Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
Protein Phosphorylation
Transforming Growth Factor Beta Receptor Signaling Pathway
Cell Proliferation
Gene Expression
Viral Process
Regulation Of Histone Modification
Replication Fork Arrest
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Viral Transcription
Negative Regulation Of Cell Cycle Arrest
Cellular Response To Cytokine Stimulus
Pathways
Loss of Function of TGFBR2 in Cancer
Formation of HIV-1 elongation complex containing HIV-1 Tat
RNA Polymerase II Transcription
HIV Infection
SMAD2/3 MH2 Domain Mutants in Cancer
Tat-mediated elongation of the HIV-1 transcript
Tat-mediated HIV elongation arrest and recovery
TGFBR1 LBD Mutants in Cancer
RNA Polymerase II Pre-transcription Events
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
HIV elongation arrest and recovery
HIV Life Cycle
Generic Transcription Pathway
HIV Transcription Elongation
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Host Interactions of HIV factors
Loss of Function of SMAD4 in Cancer
Interactions of Tat with host cellular proteins
TGFBR1 KD Mutants in Cancer
Pausing and recovery of Tat-mediated HIV elongation
Loss of Function of TGFBR1 in Cancer
Late Phase of HIV Life Cycle
Formation of RNA Pol II elongation complex
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Pausing and recovery of HIV elongation
Formation of HIV elongation complex in the absence of HIV Tat
Transcription of the HIV genome
SMAD4 MH2 Domain Mutants in Cancer
RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Systolic blood pressure (
19430483
)
Protein-Protein Interactions
15 interactors:
CCDC36
CCNT1
CDK9
GATA1
MEOX2
PIM1
PIN1
PRDM14
RNPS1
SPRY1
SPRY2
TADA3
TCF12
TERF1
TERF2
56 interactors:
ACTL6A
AFF4
AR
BCL10
BRCA1
CASK
CCNK
CCNT1
CCNT2
CDC34
CDC7
CDK5R1
CDK7
CTD
CTDP1
CTDSPL
CUL1
DHX30
FBXO25
GRN
GTF2F1
HEXIM1
HEXIM2
HIST2H2BE
HLTF
HSPA1A
HTATSF1
IL6ST
MBP
MDFIC
MED21
MYBL2
NBN
NFKB1
NR2E3
PIN1
POLR2A
RB1
RCHY1
RELA
RMND5B
RN7SK
SERPINH1
SKP1
SKP2
SMAD1
SMAD2
SMAD3
STAT3
STK36
SUPT5H
TAF7
TP53
TRAF2
UBE2A
ZMYM6
Entrez ID
124790
1025
HPRD ID
08129
16016
Ensembl ID
ENSG00000168517
ENSG00000136807
Uniprot IDs
Q96MH2
P50750
PDB IDs
1PF6
3BLH
3BLQ
3BLR
3LQ5
3MI9
3MIA
3MY1
3TN8
3TNH
3TNI
4BCF
4BCG
4BCH
4BCI
4BCJ
4EC8
4EC9
4IMY
Enriched GO Terms of Interacting Partners
?
Regulation Of Metabolic Process
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Cell Cycle
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Protein Metabolic Process
Telomeric Loop Formation
Age-dependent Telomere Shortening
Regulation Of Protein Phosphorylation
Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Telomere Maintenance Via Telomere Shortening
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Negative Regulation Of DNA Replication
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Phosphorylation
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of ERK1 And ERK2 Cascade
Macromolecule Biosynthetic Process
Regulation Of Chromosome Organization
Transcription From RNA Polymerase II Promoter
Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cell Cycle
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Gene Expression
Replicative Cell Aging
Transcription, DNA-templated
Regulation Of Nuclear Cell Cycle DNA Replication
Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance
Bud Elongation Involved In Lung Branching
RNA Biosynthetic Process
Nitrogen Compound Metabolic Process
Cell Fate Commitment
Negative Regulation Of DNA Metabolic Process
Mitotic Cell Cycle Process
Nucleobase-containing Compound Metabolic Process
Chromatin Organization
Mitotic Cell Cycle
Negative Regulation Of Ras GTPase Activity
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Regulation Of Telomere Maintenance
Regulation Of DNA Replication
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Metabolic Process
Viral Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Transcription, DNA-templated
Positive Regulation Of Gene Expression
RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Protein Metabolic Process
Macromolecule Biosynthetic Process
Gene Expression
RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Cell Cycle
Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Cellular Process
Transcription Initiation From RNA Polymerase II Promoter
Cellular Metabolic Process
Nitrogen Compound Metabolic Process
Positive Regulation Of Viral Transcription
Regulation Of Phosphorylation
Regulation Of Protein Phosphorylation
DNA-templated Transcription, Initiation
Transcription Elongation From RNA Polymerase II Promoter
Regulation Of Phosphorus Metabolic Process
Biosynthetic Process
Regulation Of Viral Transcription
Cell Cycle
Positive Regulation Of Viral Process
DNA-templated Transcription, Elongation
Response To Stimulus
Regulation Of Cell Proliferation
Negative Regulation Of Gene Expression
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Cycle
Tagcloud
?
affects
associate
bulk
ccnk
cdk12
cdk13
cdks
ctd
elongation
far
flag
hct116
heptad
implementing
numerous
paralog
partner
phosphorylate
preferentially
processing
repeat
reveals
rna
sec
seq
snorna
super
tagged
tefb
Tagcloud (Difference)
?
affects
associate
bulk
ccnk
cdk12
cdk13
cdks
ctd
elongation
far
flag
hct116
heptad
implementing
numerous
paralog
partner
phosphorylate
preferentially
processing
repeat
reveals
rna
sec
seq
snorna
super
tagged
tefb
Tagcloud (Intersection)
?