CKM and FHL2

Number of citations of the paper that reports this interaction (PMID 12432079)
54

Data Source:
HPRD (in vitro)

		CKM	FHL2
Gene Name		creatine kinase, muscle	four and a half LIM domains 2
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Focal Adhesion Actin Cytoskeleton Z Disc M Band
	Molecular Function	Creatine Kinase Activity ATP Binding	Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Identical Protein Binding Androgen Receptor Binding
	Biological Process	Creatine Metabolic Process Phosphorylation Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Phosphocreatine Biosynthetic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Transcription, DNA-templated Response To Hormone Androgen Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation
Pathways		Metabolism of amino acids and derivatives Creatine metabolism	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs		Creatine (Diaminomethyl-Methyl-Amino)-Acetic Acid Adenosine-5\'-Diphosphate D-Arginine
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ASB9 CBLC CKB FHL2 MYOC MYOM2 TRIM54 TRIM55 TRIM63 YWHAQ	92 interactors: ADAM17 AK1 APP AR ARHGAP9 ATXN1 BANP BLZF1 BMPR2 BRCA1 CAPN1 CARD8 CCDC92 CKM CREBBP CSK CSN2 CTNNB1 DCP1A DPF2 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EIF6 EP300 ESR1 FAM129A FAM154A FHL1 FHL3 FHL5 FOXO1 GLYR1 GNG12 HAND1 HIF1A ID3 IGFBP5 IKZF4 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 MCM7 MYBPC1 NRF1 PFKM PHB2 PSEN2 PUF60 RAI2 REL REV1 RFX3 RUNX2 SAP30BP SFPQ SIGLEC6 SLC34A1 SMAD2 SMAD3 SMAD4 SP2 SRF STAT3 TNFRSF11A TRAF6 TRIM55 TRIM63 TTN WT1 ZBTB16 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF212 ZNF3 ZNF331 ZNF408 ZNF417 ZNF626 ZNF638
Entrez ID		1158	2274
HPRD ID		00426	04026
Ensembl ID		ENSG00000104879	ENSG00000115641
Uniprot IDs		B2R892 P06732	J3KNW4 Q14192 Q2XQU9 Q6I9R8
PDB IDs		1I0E	1X4K 1X4L 2D8Z
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Adaptation Substantia Nigra Development Muscle System Process Signal Transduction Neural Nucleus Development Signaling Cell Communication ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy Midbrain Development ERBB2 Signaling Pathway Cellular Response To Stimulus Atrial Cardiac Muscle Cell Development Protein Ubiquitination Osteoblast Differentiation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Modification By Small Protein Conjugation Negative Regulation Of Cytoskeleton Organization Non-canonical Wnt Signaling Pathway Via JNK Cascade Skeletal Muscle Atrophy Cellular Chloride Ion Homeostasis Non-canonical Wnt Signaling Pathway Via MAPK Cascade Striated Muscle Atrophy Muscle Atrophy Clustering Of Voltage-gated Sodium Channels Chloride Ion Homeostasis Muscle Contraction Response To Stimulus Creatine Metabolic Process Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Neuronal Ion Channel Clustering Regulation Of Organelle Organization Negative Regulation Of Actin Filament Bundle Assembly Ossification Heart Trabecula Formation	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Organ Development Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Embryo Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Developmental Process Negative Regulation Of Transcription, DNA-templated Formation Of Primary Germ Layer Negative Regulation Of Cellular Metabolic Process Tissue Development Anatomical Structure Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gastrulation Regulation Of Signaling Anatomical Structure Development Response To Organic Substance Organ Morphogenesis Embryonic Morphogenesis
Tagcloud ?		auto cd cdai ckms colitis crohn diphthamide gangliosides gm3 ibd ibds immunomodulating immunomodulation implicate kp kynurenine metabolites metabolome metabolomics nineteen picolinic plasmas q qa quinolinic th17 uc ulcerative untargeted	acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly
Tagcloud (Difference) ?		auto cd cdai ckms colitis crohn diphthamide gangliosides gm3 ibd ibds immunomodulating immunomodulation implicate kp kynurenine metabolites metabolome metabolomics nineteen picolinic plasmas q qa quinolinic th17 uc ulcerative untargeted	acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly
Tagcloud (Intersection) ?