CKM and TRIM54

Number of citations of the paper that reports this interaction (PMID 18222470)
28

Data Source:
HPRD (in vivo)

		CKM	TRIM54
Gene Name		creatine kinase, muscle	tripartite motif containing 54
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Microtubule Microtubule Associated Complex Z Disc
	Molecular Function	Creatine Kinase Activity ATP Binding	Signal Transducer Activity Microtubule Binding Zinc Ion Binding
	Biological Process	Creatine Metabolic Process Phosphorylation Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Phosphocreatine Biosynthetic Process	Microtubule-based Process Negative Regulation Of Microtubule Depolymerization Signal Transduction Multicellular Organismal Development Cell Differentiation
Pathways		Metabolism of amino acids and derivatives Creatine metabolism
Drugs		Creatine (Diaminomethyl-Methyl-Amino)-Acetic Acid Adenosine-5\'-Diphosphate D-Arginine
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ASB9 CBLC CKB FHL2 MYOC MYOM2 TRIM54 TRIM55 TRIM63 YWHAQ	127 interactors: ADCY4 ALS2CR11 ARFIP2 ARHGEF5 ATXN3 ATXN3L ATXN7 BYSL C12orf49 C1orf109 C1orf216 C1QTNF2 CALM3 CARD9 CCDC102B CCDC146 CCDC28A CCDC67 CCDC87 CDK18 CDKN1A CEP57L1 CHCHD2 CKM CRADD CWF19L2 CYTH4 DCUN1D1 DNAL4 DTX2 EHHADH EIF4E2 ELMO1 ENKD1 EPM2AIP1 EXOSC5 FAM110A FAM124A FAM124B FAM161A FARS2 FBF1 FLNC GEM GMCL1 GTF2IRD2 HAUS1 ING3 INPP5J IQUB JOSD1 KDM1A KIFC3 KLHL38 KPNA2 KRT6A KRT6B KRT6C LENG1 LIN37 LMO2 LNX1 LSM2 MAPK3 MBD3 MCM7 MEAF6 MFAP1 MID2 MYO5B NGLY1 OSTF1 OTUB1 OTUB2 PIK3R3 PPP1R18 PRF1 RABGEF1 RAD23A RBM41 RCOR3 RSRC2 SCNM1 SDCBP SENP3 SH2D1B SMARCE1 SNF8 SPG21 SSX2IP STAM STRA13 TBC1D22B TCEA2 TCEB3 THOC1 TRIM55 TRIM63 TSHZ3 TTC23 UBE2D3 UBE2I UBE2U UCHL1 UCHL3 UCHL5 USHBP1 USP15 USP18 USP2 USP21 USP33 USP4 USP5 USP7 USP8 UTP14C VPS28 WDR34 WDYHV1 YOD1 ZBTB16 ZGPAT ZNF250 ZNF417 ZNF572 ZNF587
Entrez ID		1158	57159
HPRD ID		00426	05928
Ensembl ID		ENSG00000104879	ENSG00000138100
Uniprot IDs		B2R892 P06732	Q9BYV2
PDB IDs		1I0E	3Q1D
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Adaptation Substantia Nigra Development Muscle System Process Signal Transduction Neural Nucleus Development Signaling Cell Communication ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy Midbrain Development ERBB2 Signaling Pathway Cellular Response To Stimulus Atrial Cardiac Muscle Cell Development Protein Ubiquitination Osteoblast Differentiation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Modification By Small Protein Conjugation Negative Regulation Of Cytoskeleton Organization Non-canonical Wnt Signaling Pathway Via JNK Cascade Skeletal Muscle Atrophy Cellular Chloride Ion Homeostasis Non-canonical Wnt Signaling Pathway Via MAPK Cascade Striated Muscle Atrophy Muscle Atrophy Clustering Of Voltage-gated Sodium Channels Chloride Ion Homeostasis Muscle Contraction Response To Stimulus Creatine Metabolic Process Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Neuronal Ion Channel Clustering Regulation Of Organelle Organization Negative Regulation Of Actin Filament Bundle Assembly Ossification Heart Trabecula Formation	Protein Deubiquitination Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Proteolysis Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Cellular Protein Metabolic Process Regulation Of Metabolic Process Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Organelle Organization Regulation Of Protein Catabolic Process Protein Metabolic Process Histone Deubiquitination RNA Metabolic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Process Monoubiquitinated Protein Deubiquitination Histone Modification Gene Expression RNA Biosynthetic Process Chromatin Modification Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Regulation Of Proteolysis Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Chromatin Organization Cellular Response To DNA Damage Stimulus Nitrogen Compound Metabolic Process Chromosome Organization Cellular Response To Heat Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		auto cd cdai ckms colitis crohn diphthamide gangliosides gm3 ibd ibds immunomodulating immunomodulation implicate kp kynurenine metabolites metabolome metabolomics nineteen picolinic plasmas q qa quinolinic th17 uc ulcerative untargeted
Tagcloud (Difference) ?		auto cd cdai ckms colitis crohn diphthamide gangliosides gm3 ibd ibds immunomodulating immunomodulation implicate kp kynurenine metabolites metabolome metabolomics nineteen picolinic plasmas q qa quinolinic th17 uc ulcerative untargeted
Tagcloud (Intersection) ?