SLC25A26 and CRYAA

Number of citations of the paper that reports this interaction (PubMedID 24453475)
30

Data Source:
BioGRID (pull down)

		SLC25A26	CRYAA
Description		solute carrier family 25 member 26	crystallin alpha A
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	S-adenosyl-L-methionine Transmembrane Transporter Activity Antiporter Activity S-adenosyl-L-methionine:S-adenosyl-L-homocysteine Antiporter Activity	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Monoatomic Ion Transport S-adenosyl-L-methionine Transport Purine Nucleoside Transmembrane Transport Macromolecule Methylation L-alpha-amino Acid Transmembrane Transport Mitochondrial S-adenosyl-L-methionine Transmembrane Transport	Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis
Pathways		SLC-mediated transport of organic cations
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015 30061737) Binge eating behaviour and bipolar disorder ( 29391396) Colorectal cancer ( 26151821) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean corpuscular hemoglobin concentration ( 32888494) PR interval ( 32439900) QRS duration ( 21076409 27659466)	Age-related nuclear cataracts ( 24951543 33311586) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Metabolite levels ( 23823483) Systolic blood pressure ( 27618452 27841878 28739976)
Interacting Genes		2 interacting genes: CRYAA FBXO7	134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20
Entrez ID		115286	1409
HPRD ID		15357	00427
Ensembl ID		ENSG00000144741	ENSG00000160202
Uniprot IDs		A0A8I5KS24 H7C430 Q70HW3	A0A8C8KJZ9 P02489
PDB IDs			6T1R
Enriched GO Terms of Interacting Partners?		Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Lewy Body Core Regulation Of Protein Stability Lens Fiber Cell Morphogenesis Tubulin Complex Assembly Response To UV-A Negative Regulation Of Programmed Cell Death Protein-containing Complex Structural Constituent Of Eye Lens Embryonic Eye Morphogenesis Negative Regulation Of Apoptotic Process Apoptotic Process Involved In Morphogenesis Protein Refolding Embryonic Camera-type Eye Morphogenesis Lens Morphogenesis In Camera-type Eye Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Targeting To Mitochondrion Apoptotic Process Involved In Development Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Lens Development In Camera-type Eye Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitophagy Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Eye Morphogenesis Negative Regulation Of Intracellular Transport Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Autophagy Of Mitochondrion SCF Ubiquitin Ligase Complex	Structural Constituent Of Eye Lens Lens Development In Camera-type Eye
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