GPN1 and XPA

Number of citations of the paper that reports this interaction (PMID 11058119)
17

Data Source:
HPRD (two hybrid)

		GPN1	XPA
Gene Name		GPN-loop GTPase 1	xeroderma pigmentosum, complementation group A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Golgi Apparatus Intercellular Bridge
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Damaged DNA Binding Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Metabolic Process	Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Multicellular Organism Growth
Pathways			Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER Dual incision reaction in GG-NER
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Protein-Protein Interactions		4 interactors: CSNK2A1 MBD2 XPA ZBED1	20 interactors: ATM ATR DDB1 DDB2 ERCC1 ERCC6 GPN1 GTF2E2 GTF2H1 HERC2 MSH2 MSH3 NDEL1 PRKDC RASSF1 RPA1 RPA2 RPA4 TRIM27 XAB2
Entrez ID		11321	7507
HPRD ID		10308	02045
Ensembl ID		ENSG00000198522	ENSG00000136936
Uniprot IDs		B4DQM4 Q9HCN4	P23025
PDB IDs			1D4U 1XPA 2JNW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Wnt Signaling Pathway	DNA Repair Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair, DNA Damage Removal DNA Recombination Transcription-coupled Nucleotide-excision Repair Response To Stress Double-strand Break Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Response To UV Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Response To Radiation DNA Catabolic Process DNA Damage Checkpoint Cellular Nitrogen Compound Metabolic Process Cell Cycle Process Response To Abiotic Stimulus Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Heat Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Cell Cycle Checkpoint Cell Cycle Chromosome Organization Aromatic Compound Catabolic Process Pyrimidine Dimer Repair Response To Gamma Radiation Mismatch Repair Cellular Response To Stimulus Immunoglobulin Production Cellular Macromolecule Catabolic Process Response To Light Stimulus Cellular Response To Heat Telomere Maintenance Mitotic Cell Cycle Process Reproduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Organelle Organization Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Mitotic Cell Cycle Response To X-ray Mitotic Recombination
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