GPN1 and RAB10

Data Source: HiPPIP (Novel)

		GPN1	RAB10
Name		GPN-loop GTPase 1	RAB10, member RAS oncogene family
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Golgi Membrane Exocyst Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cilium Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Insulin-responsive Compartment Cell Projection Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Exocytic Vesicle Endoplasmic Reticulum Tubular Network Secretory Vesicle
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Myosin V Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	None	Exocytosis Golgi To Plasma Membrane Transport Axonogenesis Protein Transport Vesicle-mediated Transport Endosomal Transport Antigen Processing And Presentation Polarized Epithelial Cell Differentiation Cellular Response To Insulin Stimulus Golgi To Plasma Membrane Protein Transport Regulated Exocytosis Establishment Of Neuroblast Polarity Endoplasmic Reticulum Tubular Network Organization Protein Localization To Plasma Membrane Establishment Of Protein Localization To Membrane Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Cell-cell Adhesion Protein Localization To Basolateral Plasma Membrane
Pathways		None	Translocation of SLC2A4 (GLUT4) to the plasma membrane Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
GWAS		Bipolar disorder ( 31043756 ) Fasting blood glucose adjusted for BMI ( 25625282 ) Nonalcoholic fatty liver disease ( 29385134 ) Oral cavity cancer ( 27749845 ) Periodontitis (CDC/AAP) ( 24024966 ) Schizophrenia ( 26198764 )	Apolipoprotein B levels ( 32203549 ) Glycated hemoglobin levels ( 34059833 ) Immune response to smallpox vaccine (IL-6) ( 22542470 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Metabolite levels (HVA) ( 23319000 ) Metabolite levels (HVA-5-HIAA Factor score) ( 23319000 ) Metabolite levels (HVA/MHPG ratio) ( 23319000 ) Platelet distribution width ( 32888494 )
Novel Interactors		1 novel interactors: RAB10	8 novel interactors: ATRAID DNAJC27 EFR3B GPN1 IFT172 PLP2 PREB TP53I3
Interacting Genes		5 interacting genes: CSNK2A1 MBD2 RPAP1 XPA ZBED1	10 interacting genes: APP CEBPA ENOPH1 EVI5L MICAL1 MTNR1A PPBP RABIF RIMS1 SEPTIN9
Entrez ID		11321	10890
HPRD ID		10308	06692
Ensembl ID		ENSG00000198522	ENSG00000084733
Uniprot IDs		Q53RZ9 Q9HCN4	P61026
PDB IDs		Not available	5LPN 5SZJ
GO Terms Enriched among Interactors		Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Wnt Signaling Pathway PML Body Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair Factor 1 Complex Cellular Response To Serotonin Protein Autosumoylation Protein Localization To Basolateral Plasma Membrane Establishment Of Neuroblast Polarity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Satellite DNA Binding Positive Regulation Of Aggrephagy Response To Bisphenol A Insulin-responsive Compartment	None