GPN1 and RPAP1

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		GPN1	RPAP1
Name		GPN-loop GTPase 1	RNA polymerase II associated protein 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	DNA-directed RNA Polymerase Complex Nucleus
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity	DNA Binding Protein Binding Transferase Activity Nucleotidyltransferase Activity
	Biological Process	None	Transcription By RNA Polymerase II
GWAS		Bipolar disorder ( 31043756 ) Fasting blood glucose adjusted for BMI ( 25625282 ) Nonalcoholic fatty liver disease ( 29385134 ) Oral cavity cancer ( 27749845 ) Periodontitis (CDC/AAP) ( 24024966 ) Schizophrenia ( 26198764 )	A body shape index ( 34021172 ) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880 ) Lung function (FEV1/FVC) ( 30175238 30804560 ) Medication use (drugs used in diabetes) ( 31015401 ) Peak expiratory flow ( 30804560 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		5 interacting genes: CSNK2A1 MBD2 RPAP1 XPA ZBED1	7 interacting genes: GPN1 POLR2B POLR2C POLR2G POLR2L POT1 TERF2IP
Entrez ID		11321	26015
HPRD ID		10308	11522
Ensembl ID		ENSG00000198522	ENSG00000103932
Uniprot IDs		Q53RZ9 Q9HCN4	A8K2F9 Q9BWH6
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Wnt Signaling Pathway PML Body Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair Factor 1 Complex Cellular Response To Serotonin Protein Autosumoylation Protein Localization To Basolateral Plasma Membrane Establishment Of Neuroblast Polarity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Satellite DNA Binding Positive Regulation Of Aggrephagy Response To Bisphenol A Insulin-responsive Compartment	RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Complex Nucleobase-containing Compound Biosynthetic Process DNA-directed RNA Polymerase Activity Macromolecule Biosynthetic Process Shelterin Complex Transcription By RNA Polymerase II Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping DNA-templated Transcription Nucleic Acid Metabolic Process Nucleoplasm Telomere Maintenance Via Telomerase Chromosome, Telomeric Region RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of Chromosome Organization DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Telomeric Loop Disassembly Positive Regulation Of Chromosome Organization Negative Regulation Of DNA Recombination At Telomere Regulation Of Telomere Maintenance Nucleus Ribonucleoside Binding RNA-directed RNA Polymerase Activity RNA-templated Transcription RNA Metabolic Process Negative Regulation Of DNA Metabolic Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomere Organization Regulation Of Double-strand Break Repair Telomeric D-loop Binding Telomere Assembly Single-stranded Telomeric DNA Binding 5'-3' RNA Polymerase Activity Macromolecule Metabolic Process Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Protection From Non-homologous End Joining At Telomere DEAD/H-box RNA Helicase Binding