WNK4 and KLHL3

Number of citations of the paper that reports this interaction (PubMedID 37285722)
0

Data Source:
BioGRID (pull down)

		WNK4	KLHL3
Description		WNK lysine deficient protein kinase 4	kelch like family member 3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Bicellular Tight Junction Membrane Protein-containing Complex Cell Body Anchoring Junction	Cytoplasm Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Ion Channel Inhibitor Activity Kinase Activity Transferase Activity Chloride Ion Binding Protein Serine Kinase Activity	Actin Binding Structural Molecule Activity Protein Binding Cullin Family Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Response To Dietary Excess Renal Sodium Ion Transport Protein Phosphorylation Chloride Transport Inflammatory Response Signal Transduction Intracellular Protein Localization Regulation Of Blood Pressure Response To Xenobiotic Stimulus Gene Expression Negative Regulation Of Sodium Ion Transport Intracellular Chloride Ion Homeostasis Intracellular Signal Transduction Sodium Ion Transmembrane Transport Aldosterone Secretion Macrophage Activation Homeostatic Process Monoatomic Ion Homeostasis Calcium Ion Homeostasis Renal Sodium Ion Absorption ERK1 And ERK2 Cascade Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Distal Tubule Morphogenesis Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Protein Localization To Plasma Membrane Regulation Of Potassium Ion Export Across Plasma Membrane	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Gene Expression Macroautophagy Protein Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Monoatomic Ion Homeostasis Potassium Ion Homeostasis Renal Absorption Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis
Pathways		Stimuli-sensing channels	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS			Bronchopulmonary dysplasia ( 23897914) Heart failure ( 31919418) Hemoglobin ( 32888494) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)
Interacting Genes		13 interacting genes: AKT1 BCL6 CLDN1 CLDN2 CLDN3 CLDN4 HMGB1 KLHL2 KLHL3 NEDD4L OXSR1 SLC12A3 STK39	16 interacting genes: AKT1 CFAP206 GNAI1 GNAO1 KLHL12 MORF4L2 OPRD1 PPP3CA PRKACA RBX1 SYNCRIP SYT2 TNPO2 UBE2D3 WNK3 WNK4
Entrez ID		65266	26249
HPRD ID		03505	09011
Ensembl ID		ENSG00000126562	ENSG00000146021
Uniprot IDs		Q96J92	Q9UH77
PDB IDs		2V3S 4CH9 4CHB	4CH9 4HXI 5NKP
Enriched GO Terms of Interacting Partners?		Renal Absorption Positive Regulation Of Cell Motility Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Renal Sodium Ion Transport Renal Sodium Ion Absorption Positive Regulation Of Locomotion Tight Junction Negative Regulation Of Transmembrane Transport Renal System Process Bicellular Tight Junction Assembly Potassium Channel Inhibitor Activity Positive Regulation Of Cell Migration Tight Junction Assembly Tight Junction Organization Positive Regulation Of Wound Healing Structural Molecule Activity Sodium Ion Transport Regulation Of Cell Motility Regulation Of Locomotion Cell-cell Junction Negative Regulation Of Transport Response To Steroid Hormone Response To Ketone Negative Regulation Of Potassium Ion Transmembrane Transport Response To Alcohol Negative Regulation Of Potassium Ion Transport Monoatomic Ion Transport Cell-cell Junction Assembly Bicellular Tight Junction Metal Ion Transport Regulation Of Cell Migration Cell Volume Homeostasis Regulation Of Wound Healing Response To Hormone Regulation Of Mononuclear Cell Migration Response To Corticosteroid Apical Plasma Membrane Inorganic Ion Transmembrane Transport Regulation Of Response To Wounding Cell-cell Junction Organization Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Cellular Response To Cytokine Stimulus Identical Protein Binding Regulation Of Endodeoxyribonuclease Activity Paracellular Transport Ion Channel Regulator Activity Response To Lipid Homeostatic Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules	Renal Sodium Ion Transport Renal Sodium Ion Absorption Renal Absorption Renal System Process Regulation Of Metal Ion Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Secretion Negative Regulation Of Protein Localization Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Postsynaptic Modulation Of Chemical Synaptic Transmission Proteasomal Protein Catabolic Process Regulation Of Transport Positive Regulation Of Steroid Biosynthetic Process Adenylate Cyclase Regulator Activity Positive Regulation Of Steroid Metabolic Process Negative Regulation Of Pancreatic Juice Secretion Ubiquitin-dependent Protein Catabolic Process Regulation Of System Process Modification-dependent Protein Catabolic Process Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization Regulation Of Cholesterol Metabolic Process Protein Catabolic Process Negative Regulation Of Secretion Protein Monoubiquitination Sodium Ion Transport Proteolysis Involved In Protein Catabolic Process TORC1 Signaling Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Negative Regulation Of TORC1 Signaling Regulation Of Sodium Ion Transport Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Biological Quality Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Calcium Ion Transport Regulation Of Steroid Biosynthetic Process Protein Modification Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway TOR Signaling Negative Regulation Of TOR Signaling Nuclear Transport Nucleocytoplasmic Transport Vascular Endothelial Cell Response To Fluid Shear Stress Nucleotide Binding
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