WNK4 and CLDN2

Number of citations of the paper that reports this interaction (PMID 15070779)
47

Data Source:
HPRD (in vivo)

		WNK4	CLDN2
Gene Name		WNK lysine deficient protein kinase 4	claudin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Tight Junction	Plasma Membrane Tight Junction Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity	Structural Molecule Activity Identical Protein Binding
	Biological Process	Protein Phosphorylation Ion Transport Chloride Transport Protein Localization Intracellular Signal Transduction Regulation Of Cellular Process Ion Homeostasis Renal Sodium Ion Absorption Distal Tubule Morphogenesis Negative Regulation Of Pancreatic Juice Secretion	Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules
Pathways		Ion channel transport Stimuli-sensing channels	Cell junction organization Cell-cell junction organization Tight junction interactions
Drugs
Diseases
GWAS			Pancreatitis ( 23143602)
Protein-Protein Interactions		11 interactors: AKT1 BCL6 CLDN1 CLDN2 CLDN3 CLDN4 KLHL2 KLHL3 NEDD4L SLC12A3 STK39	10 interactors: KRT31 KRTAP10-3 KRTAP4-12 LNX1 NOTCH2NL PIAS2 TJP1 TJP2 UBE2I WNK4
Entrez ID		65266	9075
HPRD ID		03505	06471
Ensembl ID		ENSG00000126562	ENSG00000165376
Uniprot IDs		B0LPI0 Q96J92	P57739
PDB IDs		2V3S
Enriched GO Terms of Interacting Partners?		Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Water Homeostasis Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Ion Transport Homeostatic Process Negative Regulation Of Potassium Ion Transmembrane Transport Chemical Homeostasis Establishment Of Skin Barrier Regulation Of Water Loss Via Skin Negative Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Ion Transport Protein Import Into Nucleus, Translocation Protein Ubiquitination Positive Regulation Of Sodium Ion Transport Protein Modification By Small Protein Conjugation Regulation Of Potassium Ion Transmembrane Transport Protein K48-linked Ubiquitination Negative Regulation Of Transporter Activity Sodium Ion Transport Multicellular Organismal Water Homeostasis Regulation Of Potassium Ion Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Sodium Ion Transport Glycogen Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Transport Response To Osmotic Stress Regulation Of Ion Transmembrane Transport Positive Regulation Of Caveolin-mediated Endocytosis Response To Abiotic Stimulus Peptidyl-serine Phosphorylation Negative Regulation Of Mast Cell Cytokine Production Distal Tubule Morphogenesis Negative Regulation Of Rubidium Ion Transport Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity Negative Regulation Of Isotype Switching To IgE Isotypes Protein Import Into Nucleus Nuclear Import Cell Adhesion Negative Regulation Of T-helper 2 Cell Differentiation Renal Sodium Ion Absorption Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Body Fluid Levels	Establishment Of Endothelial Intestinal Barrier Protein Sumoylation Establishment Of Endothelial Barrier Hippo Signaling Endothelial Cell Development Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Epithelium Development Execution Phase Of Apoptosis Endothelial Cell Differentiation Cell-cell Signaling Involved In Cell-cell Junction Organization Positive Regulation Of SUMO Transferase Activity Endothelium Development Protein Modification By Small Protein Conjugation Distal Tubule Morphogenesis Response To Magnetism Renal Sodium Ion Absorption Tissue Development Negative Regulation Of Pancreatic Juice Secretion Renal Sodium Ion Transport Epithelial Cell Development Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Peptidyl-lysine Modification Renal Absorption Negative Regulation Of Androgen Receptor Signaling Pathway Distal Tubule Development Negative Regulation Of Vascular Permeability
Tagcloud ?		aii cotransporter cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch klhl3 ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents reabsorption s433 salt volume wnk1 wnks	adherens atp1a1 atp1b1 bbs1 biogenesis cdh1 cilium delineation dynamic fasn foxo1 glycolytic hif1a invaluable junction maturation matured metabolomic monolayer nutrient profound proliferating tight tjp3 transam transcriptomic tubule uncovered utilizing
Tagcloud (Difference) ?		aii cotransporter cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch klhl3 ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents reabsorption s433 salt volume wnk1 wnks	adherens atp1a1 atp1b1 bbs1 biogenesis cdh1 cilium delineation dynamic fasn foxo1 glycolytic hif1a invaluable junction maturation matured metabolomic monolayer nutrient profound proliferating tight tjp3 transam transcriptomic tubule uncovered utilizing
Tagcloud (Intersection) ?