WNK4 and CLDN4

Number of citations of the paper that reports this interaction (PMID 15070779)
47

Data Source:
HPRD (in vitro, in vivo)

		WNK4	CLDN4
Gene Name		WNK lysine deficient protein kinase 4	claudin 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Tight Junction	Plasma Membrane Integral Component Of Plasma Membrane Tight Junction Basal Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity	Transmembrane Signaling Receptor Activity Structural Molecule Activity Identical Protein Binding
	Biological Process	Protein Phosphorylation Ion Transport Chloride Transport Protein Localization Intracellular Signal Transduction Regulation Of Cellular Process Ion Homeostasis Renal Sodium Ion Absorption Distal Tubule Morphogenesis Negative Regulation Of Pancreatic Juice Secretion	Signal Transduction Female Pregnancy Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Response To Progesterone Establishment Of Skin Barrier
Pathways		Ion channel transport Stimuli-sensing channels	Cell junction organization Cell-cell junction organization Tight junction interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: AKT1 BCL6 CLDN1 CLDN2 CLDN3 CLDN4 KLHL2 KLHL3 NEDD4L SLC12A3 STK39	4 interactors: EPHA2 SHBG TJP1 WNK4
Entrez ID		65266	1364
HPRD ID		03505	04218
Ensembl ID		ENSG00000126562	ENSG00000189143
Uniprot IDs		B0LPI0 Q96J92	O14493 Q75L80
PDB IDs		2V3S
Enriched GO Terms of Interacting Partners?		Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Water Homeostasis Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Ion Transport Homeostatic Process Negative Regulation Of Potassium Ion Transmembrane Transport Chemical Homeostasis Establishment Of Skin Barrier Regulation Of Water Loss Via Skin Negative Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Ion Transport Protein Import Into Nucleus, Translocation Protein Ubiquitination Positive Regulation Of Sodium Ion Transport Protein Modification By Small Protein Conjugation Regulation Of Potassium Ion Transmembrane Transport Protein K48-linked Ubiquitination Negative Regulation Of Transporter Activity Sodium Ion Transport Multicellular Organismal Water Homeostasis Regulation Of Potassium Ion Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Sodium Ion Transport Glycogen Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Transport Response To Osmotic Stress Regulation Of Ion Transmembrane Transport Positive Regulation Of Caveolin-mediated Endocytosis Response To Abiotic Stimulus Peptidyl-serine Phosphorylation Negative Regulation Of Mast Cell Cytokine Production Distal Tubule Morphogenesis Negative Regulation Of Rubidium Ion Transport Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity Negative Regulation Of Isotype Switching To IgE Isotypes Protein Import Into Nucleus Nuclear Import Cell Adhesion Negative Regulation Of T-helper 2 Cell Differentiation Renal Sodium Ion Absorption Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Body Fluid Levels	Cell-cell Signaling Involved In Cell-cell Junction Organization Primary Spermatocyte Growth Notochord Cell Development Epithelium Development Epithelial Cell Development Distal Tubule Morphogenesis Axial Mesoderm Formation Response To Magnetism Renal Sodium Ion Absorption Negative Regulation Of Pancreatic Juice Secretion Renal Sodium Ion Transport Notochord Formation Axial Mesoderm Morphogenesis Lens Fiber Cell Morphogenesis Establishment Of Endothelial Intestinal Barrier Tissue Development Axial Mesoderm Development Epithelial Tube Morphogenesis Cell Development Intracellular Signal Transduction Anatomical Structure Development Notochord Morphogenesis Tube Morphogenesis Renal Absorption Distal Tubule Development Activation Of Rac GTPase Activity Negative Regulation Of Vascular Permeability Morphogenesis Of An Epithelium Developmental Process Epithelial Cell Differentiation Lens Fiber Cell Development Post-anal Tail Morphogenesis Mammary Gland Epithelial Cell Proliferation Notochord Development Anatomical Structure Morphogenesis Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Lamellipodium Assembly Positive Regulation Of Protein Localization To Plasma Membrane Tissue Morphogenesis Establishment Of Endothelial Barrier Hippo Signaling Lens Morphogenesis In Camera-type Eye Tube Development Regulation Of Vascular Permeability Lens Fiber Cell Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Protein Kinase B Signaling Activation Of Rho GTPase Activity Protein Kinase B Signaling
Tagcloud ?		aii cotransporter cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch klhl3 ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents reabsorption s433 salt volume wnk1 wnks	acta2 cdh1 cdkn1a cldn1 cldn7 ctnnb1 fn1 krt19 mapk1 mapk14 mapk3 mki67 mmp2 mmp9 muc5ac muc6 nes pdac pdacs ptgs2 rps6 rps6kb1 smad4 stains surprising synchronous tgfb1 tgfbr1 vim
Tagcloud (Difference) ?		aii cotransporter cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch klhl3 ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents reabsorption s433 salt volume wnk1 wnks	acta2 cdh1 cdkn1a cldn1 cldn7 ctnnb1 fn1 krt19 mapk1 mapk14 mapk3 mki67 mmp2 mmp9 muc5ac muc6 nes pdac pdacs ptgs2 rps6 rps6kb1 smad4 stains surprising synchronous tgfb1 tgfbr1 vim
Tagcloud (Intersection) ?