WNK4 and SLC12A3

Number of citations of the paper that reports this interaction (PMID 12515852)
89

Data Source:
HPRD (in vivo)

		WNK4	SLC12A3
Gene Name		WNK lysine deficient protein kinase 4	solute carrier family 12 (sodium/chloride transporter), member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Tight Junction	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity	Transporter Activity Protein Binding Sodium:chloride Symporter Activity
	Biological Process	Protein Phosphorylation Ion Transport Chloride Transport Protein Localization Intracellular Signal Transduction Regulation Of Cellular Process Ion Homeostasis Renal Sodium Ion Absorption Distal Tubule Morphogenesis Negative Regulation Of Pancreatic Juice Secretion	Transport Ion Transport Sodium Ion Transport Chloride Transport Sodium Ion Transmembrane Transport Transmembrane Transport Chloride Transmembrane Transport
Pathways		Ion channel transport Stimuli-sensing channels	Transport of inorganic cations/anions and amino acids/oligopeptides Cation-coupled Chloride cotransporters SLC-mediated transmembrane transport
Drugs			Bendroflumethiazide Metolazone Benzthiazide Chlorothiazide Hydrochlorothiazide Diazoxide Polythiazide Quinethazone
Diseases
GWAS			HDL cholesterol ( 20031564 23505323)
Protein-Protein Interactions		11 interactors: AKT1 BCL6 CLDN1 CLDN2 CLDN3 CLDN4 KLHL2 KLHL3 NEDD4L SLC12A3 STK39	2 interactors: PDIA3 WNK4
Entrez ID		65266	6559
HPRD ID		03505	02984
Ensembl ID		ENSG00000126562	ENSG00000070915
Uniprot IDs		B0LPI0 Q96J92	J3QSS1 P55017
PDB IDs		2V3S
Enriched GO Terms of Interacting Partners?		Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Water Homeostasis Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Ion Transport Homeostatic Process Negative Regulation Of Potassium Ion Transmembrane Transport Chemical Homeostasis Establishment Of Skin Barrier Regulation Of Water Loss Via Skin Negative Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Ion Transport Protein Import Into Nucleus, Translocation Protein Ubiquitination Positive Regulation Of Sodium Ion Transport Protein Modification By Small Protein Conjugation Regulation Of Potassium Ion Transmembrane Transport Protein K48-linked Ubiquitination Negative Regulation Of Transporter Activity Sodium Ion Transport Multicellular Organismal Water Homeostasis Regulation Of Potassium Ion Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Sodium Ion Transport Glycogen Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Transport Response To Osmotic Stress Regulation Of Ion Transmembrane Transport Positive Regulation Of Caveolin-mediated Endocytosis Response To Abiotic Stimulus Peptidyl-serine Phosphorylation Negative Regulation Of Mast Cell Cytokine Production Distal Tubule Morphogenesis Negative Regulation Of Rubidium Ion Transport Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity Negative Regulation Of Isotype Switching To IgE Isotypes Protein Import Into Nucleus Nuclear Import Cell Adhesion Negative Regulation Of T-helper 2 Cell Differentiation Renal Sodium Ion Absorption Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Body Fluid Levels	Distal Tubule Morphogenesis Renal Sodium Ion Absorption Negative Regulation Of Pancreatic Juice Secretion Renal Sodium Ion Transport Protein Retention In ER Lumen Maintenance Of Protein Localization In Endoplasmic Reticulum Renal Absorption Distal Tubule Development Homeostatic Process Protein Localization Nephron Morphogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Renal Tubule Morphogenesis Renal System Process Renal Tubule Development Protein N-linked Glycosylation Via Asparagine Kidney Morphogenesis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Protein N-linked Glycosylation Protein Import Into Nucleus Cell Redox Homeostasis Nuclear Import Protein Localization To Endoplasmic Reticulum Chloride Transport Maintenance Of Protein Location In Cell Nephron Development Maintenance Of Protein Location Maintenance Of Location In Cell Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Import Kidney Epithelium Development Response To Endoplasmic Reticulum Stress Protein Localization To Nucleus Negative Regulation Of Secretion Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Post-translational Protein Modification
Tagcloud ?		aii cotransporter cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch klhl3 ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents reabsorption s433 salt volume wnk1 wnks	adaptations adjustments alpha1beta1 arystarkhova ascending atpase compensatory convoluted cotransporter dct fxyd fxyd2 generates hypoplasia na ncc nephron nkcc2 nonetheless permissive reabsorption s71 segment t53 thiazide thick tubule twofold
Tagcloud (Difference) ?		aii cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch klhl3 ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents s433 salt volume wnk1 wnks	adaptations adjustments alpha1beta1 arystarkhova ascending atpase compensatory convoluted dct fxyd fxyd2 generates hypoplasia na ncc nephron nkcc2 nonetheless permissive s71 segment t53 thiazide thick tubule twofold
Tagcloud (Intersection) ?		cotransporter reabsorption