WNK4 and CLDN3

Number of citations of the paper that reports this interaction (PMID 15070779)
47

Data Source:
HPRD (in vivo)

		WNK4	CLDN3
Gene Name		WNK lysine deficient protein kinase 4	claudin 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Tight Junction	Integral Component Of Plasma Membrane Tight Junction Integral Component Of Membrane Lateral Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity	Transmembrane Signaling Receptor Activity Structural Molecule Activity Identical Protein Binding
	Biological Process	Protein Phosphorylation Ion Transport Chloride Transport Protein Localization Intracellular Signal Transduction Regulation Of Cellular Process Ion Homeostasis Renal Sodium Ion Absorption Distal Tubule Morphogenesis Negative Regulation Of Pancreatic Juice Secretion	Response To Hypoxia Epithelial Cell Morphogenesis Signal Transduction Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules
Pathways		Ion channel transport Stimuli-sensing channels	Cell junction organization Cell-cell junction organization Tight junction interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: AKT1 BCL6 CLDN1 CLDN2 CLDN3 CLDN4 KLHL2 KLHL3 NEDD4L SLC12A3 STK39	7 interactors: APP CLDN1 CLDN5 POM121 PRKACA TJP1 WNK4
Entrez ID		65266	1365
HPRD ID		03505	04219
Ensembl ID		ENSG00000126562	ENSG00000165215
Uniprot IDs		B0LPI0 Q96J92	O15551 Q75L79
PDB IDs		2V3S
Enriched GO Terms of Interacting Partners?		Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Water Homeostasis Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Ion Transport Homeostatic Process Negative Regulation Of Potassium Ion Transmembrane Transport Chemical Homeostasis Establishment Of Skin Barrier Regulation Of Water Loss Via Skin Negative Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Ion Transport Protein Import Into Nucleus, Translocation Protein Ubiquitination Positive Regulation Of Sodium Ion Transport Protein Modification By Small Protein Conjugation Regulation Of Potassium Ion Transmembrane Transport Protein K48-linked Ubiquitination Negative Regulation Of Transporter Activity Sodium Ion Transport Multicellular Organismal Water Homeostasis Regulation Of Potassium Ion Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Sodium Ion Transport Glycogen Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Transport Response To Osmotic Stress Regulation Of Ion Transmembrane Transport Positive Regulation Of Caveolin-mediated Endocytosis Response To Abiotic Stimulus Peptidyl-serine Phosphorylation Negative Regulation Of Mast Cell Cytokine Production Distal Tubule Morphogenesis Negative Regulation Of Rubidium Ion Transport Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity Negative Regulation Of Isotype Switching To IgE Isotypes Protein Import Into Nucleus Nuclear Import Cell Adhesion Negative Regulation Of T-helper 2 Cell Differentiation Renal Sodium Ion Absorption Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Body Fluid Levels	Chemical Homeostasis Homeostatic Process Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Organization Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly Multicellular Organismal Water Homeostasis Cellular Response To Glucose Stimulus Water Homeostasis Nuclear Envelope Organization Cell Adhesion Cellular Glucose Homeostasis Cellular Response To Carbohydrate Stimulus Cell-cell Signaling Involved In Cell-cell Junction Organization Positive Regulation Of Dense Core Granule Biogenesis Renal System Process Regulation Of Glucose Transport Cellular Chemical Homeostasis Multicellular Organismal Development Ion Homeostasis Anatomical Structure Development Regulation Of Body Fluid Levels Positive Regulation Of Mitotic Cell Cycle Cell-cell Junction Assembly Nucleus Organization Synaptic Growth At Neuromuscular Junction Histone H3-T6 Phosphorylation Response To Glucose Regulation Of Protein Binding Cell Maturation Cellular Homeostasis Distal Tubule Morphogenesis Collateral Sprouting In Absence Of Injury Developmental Process Renal Sodium Ion Absorption Response To Magnetism Response To Carbohydrate Platelet Activation Collateral Sprouting Negative Regulation Of Pancreatic Juice Secretion Renal Sodium Ion Transport Axon Midline Choice Point Recognition Cell Junction Assembly Membrane Organization Glucose Homeostasis Pathogenesis Regulation Of Peptidyl-tyrosine Phosphorylation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Cell Cycle Process Peptidyl-serine Autophosphorylation
Tagcloud ?		aii cotransporter cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch klhl3 ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents reabsorption s433 salt volume wnk1 wnks	anat asmt characterise circumventricular col11a1 cvos epcam ependyma ependymocytes lcm microdissection organum ovlt peculiar periventricular pineal ren1 sco sfo slc22a3 specialised subcommissural subfornical terminalis tph transcriptomes vasculosum ventricles vestigial
Tagcloud (Difference) ?		aii cotransporter cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch klhl3 ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents reabsorption s433 salt volume wnk1 wnks	anat asmt characterise circumventricular col11a1 cvos epcam ependyma ependymocytes lcm microdissection organum ovlt peculiar periventricular pineal ren1 sco sfo slc22a3 specialised subcommissural subfornical terminalis tph transcriptomes vasculosum ventricles vestigial
Tagcloud (Intersection) ?