WNK4 and CLDN1

Number of citations of the paper that reports this interaction (PMID 15070779)
47

Data Source:
HPRD (in vivo)

		WNK4	CLDN1
Gene Name		WNK lysine deficient protein kinase 4	claudin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Tight Junction	Integral Component Of Plasma Membrane Tight Junction Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Protein Phosphorylation Ion Transport Chloride Transport Protein Localization Intracellular Signal Transduction Regulation Of Cellular Process Ion Homeostasis Renal Sodium Ion Absorption Distal Tubule Morphogenesis Negative Regulation Of Pancreatic Juice Secretion	Cell Adhesion Viral Process Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Organization Establishment Of Skin Barrier
Pathways		Ion channel transport Stimuli-sensing channels	Cell junction organization Cell-cell junction organization Tight junction interactions
Drugs
Diseases
GWAS			Working memory ( 21107309)
Protein-Protein Interactions		11 interactors: AKT1 BCL6 CLDN1 CLDN2 CLDN3 CLDN4 KLHL2 KLHL3 NEDD4L SLC12A3 STK39	12 interactors: BRD4 CLDN3 DRG1 INADL LNX1 MMP14 MMP2 MPDZ TJP1 TJP2 TJP3 WNK4
Entrez ID		65266	9076
HPRD ID		03505	04760
Ensembl ID		ENSG00000126562	ENSG00000163347
Uniprot IDs		B0LPI0 Q96J92	A5JSJ9 O95832
PDB IDs		2V3S
Enriched GO Terms of Interacting Partners?		Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Water Homeostasis Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Ion Transport Homeostatic Process Negative Regulation Of Potassium Ion Transmembrane Transport Chemical Homeostasis Establishment Of Skin Barrier Regulation Of Water Loss Via Skin Negative Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Ion Transport Protein Import Into Nucleus, Translocation Protein Ubiquitination Positive Regulation Of Sodium Ion Transport Protein Modification By Small Protein Conjugation Regulation Of Potassium Ion Transmembrane Transport Protein K48-linked Ubiquitination Negative Regulation Of Transporter Activity Sodium Ion Transport Multicellular Organismal Water Homeostasis Regulation Of Potassium Ion Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Sodium Ion Transport Glycogen Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Transport Response To Osmotic Stress Regulation Of Ion Transmembrane Transport Positive Regulation Of Caveolin-mediated Endocytosis Response To Abiotic Stimulus Peptidyl-serine Phosphorylation Negative Regulation Of Mast Cell Cytokine Production Distal Tubule Morphogenesis Negative Regulation Of Rubidium Ion Transport Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity Negative Regulation Of Isotype Switching To IgE Isotypes Protein Import Into Nucleus Nuclear Import Cell Adhesion Negative Regulation Of T-helper 2 Cell Differentiation Renal Sodium Ion Absorption Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Body Fluid Levels	Establishment Of Endothelial Intestinal Barrier Response To Hypoxia Anatomical Structure Development Establishment Of Endothelial Barrier Hippo Signaling Tissue Development Epithelium Development Response To Abiotic Stimulus Epithelial Cell Development Endodermal Cell Differentiation Regulation Of Cell Cycle Checkpoint Developmental Process Endothelial Cell Development Endoderm Formation Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Collagen Catabolic Process Cell-cell Signaling Involved In Cell-cell Junction Organization Execution Phase Of Apoptosis Collagen Metabolic Process Endothelial Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Multicellular Organismal Metabolic Process Endothelium Development Extracellular Matrix Disassembly Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Blastocyst Development Cell Development Intracellular Signal Transduction Distal Tubule Morphogenesis Cell-cell Junction Assembly Regulation Of Cell Cycle Process Embryo Development Formation Of Primary Germ Layer Negative Regulation Of DNA Damage Checkpoint Renal Sodium Ion Absorption Response To Magnetism Histone H3-K14 Acetylation Epithelial Cell Differentiation Negative Regulation Of Pancreatic Juice Secretion Renal Sodium Ion Transport Myelination Axon Ensheathment Positive Regulation Of Spindle Checkpoint Cell Differentiation Multicellular Organismal Development Astrocyte Cell Migration Gastrulation Histone H4-K12 Acetylation Intramembranous Ossification
Tagcloud ?		aii cotransporter cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch klhl3 ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents reabsorption s433 salt volume wnk1 wnks	aldh1a1 anxa1 bcar1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		aii cotransporter cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch klhl3 ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents reabsorption s433 salt volume wnk1 wnks	aldh1a1 anxa1 bcar1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?