WNK4 and CLDN1

Number of citations of the paper that reports this interaction (PubMedID 15070779)
20

Data Source:
HPRD (in vivo)

		WNK4	CLDN1
Description		WNK lysine deficient protein kinase 4	claudin 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Bicellular Tight Junction Membrane Protein-containing Complex Cell Body Anchoring Junction	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Protein-containing Complex Tight Junction Anchoring Junction
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Ion Channel Inhibitor Activity Kinase Activity Transferase Activity Chloride Ion Binding Protein Serine Kinase Activity	Virus Receptor Activity Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Response To Dietary Excess Renal Sodium Ion Transport Protein Phosphorylation Chloride Transport Inflammatory Response Signal Transduction Intracellular Protein Localization Regulation Of Blood Pressure Response To Xenobiotic Stimulus Gene Expression Negative Regulation Of Sodium Ion Transport Intracellular Chloride Ion Homeostasis Intracellular Signal Transduction Sodium Ion Transmembrane Transport Aldosterone Secretion Macrophage Activation Homeostatic Process Monoatomic Ion Homeostasis Calcium Ion Homeostasis Renal Sodium Ion Absorption ERK1 And ERK2 Cascade Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Distal Tubule Morphogenesis Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Protein Localization To Plasma Membrane Regulation Of Potassium Ion Export Across Plasma Membrane	Cell Adhesion Establishment Of Blood-nerve Barrier Response To Toxic Substance Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Positive Regulation Of Cell Migration Response To Lipopolysaccharide Cell Junction Maintenance Maintenance Of Blood-brain Barrier Cell-cell Junction Organization Response To Ethanol Symbiont Entry Into Host Cell Protein Complex Oligomerization Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Establishment Of Skin Barrier Xenobiotic Transport Across Blood-nerve Barrier Response To Interleukin-18 Bicellular Tight Junction Assembly Cellular Response To Lead Ion Cellular Response To Type II Interferon Cellular Response To Tumor Necrosis Factor Response To Dexamethasone Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Wound Healing Establishment Of Endothelial Intestinal Barrier Liver Regeneration Positive Regulation Of Bicellular Tight Junction Assembly Cellular Response To Butyrate
Pathways		Stimuli-sensing channels	Tight junction interactions
Drugs
Diseases		Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)	Neonatal ichthyosis-sclerosing cholangitis (NISCH) syndrome; Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC)
GWAS			Optic disc size ( 31809533) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)
Interacting Genes		13 interacting genes: AKT1 BCL6 CLDN1 CLDN2 CLDN3 CLDN4 HMGB1 KLHL2 KLHL3 NEDD4L OXSR1 SLC12A3 STK39	18 interacting genes: BRD4 CD69 CD79A CLDN3 DRG1 FNDC9 LNX1 MMP14 MMP2 MPDZ MS4A3 PATJ TJP1 TJP2 TJP3 TMEM179B TMEM9 WNK4
Entrez ID		65266	9076
HPRD ID		03505	04760
Ensembl ID		ENSG00000126562	ENSG00000163347
Uniprot IDs		Q96J92	A5JSJ9 O95832
PDB IDs		2V3S 4CH9 4CHB
Enriched GO Terms of Interacting Partners?		Renal Absorption Positive Regulation Of Cell Motility Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Renal Sodium Ion Transport Renal Sodium Ion Absorption Positive Regulation Of Locomotion Tight Junction Negative Regulation Of Transmembrane Transport Renal System Process Bicellular Tight Junction Assembly Potassium Channel Inhibitor Activity Positive Regulation Of Cell Migration Tight Junction Assembly Tight Junction Organization Positive Regulation Of Wound Healing Structural Molecule Activity Sodium Ion Transport Regulation Of Cell Motility Regulation Of Locomotion Cell-cell Junction Negative Regulation Of Transport Response To Steroid Hormone Response To Ketone Negative Regulation Of Potassium Ion Transmembrane Transport Response To Alcohol Negative Regulation Of Potassium Ion Transport Monoatomic Ion Transport Cell-cell Junction Assembly Bicellular Tight Junction Metal Ion Transport Regulation Of Cell Migration Cell Volume Homeostasis Regulation Of Wound Healing Response To Hormone Regulation Of Mononuclear Cell Migration Response To Corticosteroid Apical Plasma Membrane Inorganic Ion Transmembrane Transport Regulation Of Response To Wounding Cell-cell Junction Organization Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Cellular Response To Cytokine Stimulus Identical Protein Binding Regulation Of Endodeoxyribonuclease Activity Paracellular Transport Ion Channel Regulator Activity Response To Lipid Homeostatic Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules	Bicellular Tight Junction Tight Junction Positive Regulation Of Blood-brain Barrier Permeability Cell-cell Junction Organization Maintenance Of Blood-brain Barrier Establishment Of Endothelial Barrier Anchoring Junction Endothelial Cell Development Regulation Of Blood-brain Barrier Permeability Cell Junction Organization Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Vascular Permeability Protein Localization To Cell-cell Junction Apical Junction Complex Cell-cell Junction Assembly Epithelial Cell Development Regulation Of Vascular Permeability Tight Junction Assembly Membrane Tight Junction Organization Anatomical Structure Homeostasis Tissue Homeostasis Protein Localization To Cell Junction Apical Part Of Cell Multicellular Organismal-level Homeostasis Cell Adhesion Molecule Binding Cell Junction Assembly Vascular Process In Circulatory System Cell-cell Junction Maintenance Apicolateral Plasma Membrane Circulatory System Process Plasma Membrane Regulation Of T-helper 17 Cell Differentiation Endodermal Cell Differentiation Regulation Of T-helper 17 Type Immune Response Collagen Catabolic Process Regulation Of Cell Adhesion Regulation Of Cell Fate Commitment Ovarian Follicle Development Extracellular Matrix Disassembly Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway Cell Junction Histone H4K8ac Reader Activity Aldosterone Secretion Regulation Of T-helper Cell Differentiation Cell Junction Maintenance Regulation Of Lymphocyte Differentiation Homeostatic Process Transmembrane Signaling Receptor Activity
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