PLK3 and CIB1

Number of citations of the paper that reports this interaction (PMID 10523297)
47

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro, two hybrid)

		PLK3	CIB1
Gene Name		polo-like kinase 3	calcium and integrin binding 1 (calmyrin)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Golgi Stack Centrosome Dendrite Neuronal Cell Body	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Plasma Membrane Membrane Apical Plasma Membrane Lamellipodium Growth Cone Vesicle Filopodium Tip Ruffle Membrane Sarcolemma Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Calcium Ion Binding Protein Binding Ras GTPase Binding Protein Anchor Ion Channel Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Reactive Oxygen Species Protein Phosphorylation Apoptotic Process Response To Osmotic Stress Cellular Response To DNA Damage Stimulus Mitotic Cell Cycle Checkpoint Endomitotic Cell Cycle Response To Radiation Cytoplasmic Microtubule Organization Regulation Of Cytokinesis Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Mitotic G1/S Transition Checkpoint Regulation Of Cell Division Golgi Disassembly Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia	Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell-matrix Adhesion Response To Ischemia Double-strand Break Repair Apoptotic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Endomitotic Cell Cycle Cell Adhesion Spermatid Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Neuron Projection Development Platelet Formation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Cytoplasmic Microtubule Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Thrombopoietin-mediated Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Metalloenzyme Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Division Regulation Of Cell Division Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Targeting To Membrane Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Male Germ Cell Proliferation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: AURKA CDC25C CENPU CHEK2 CIB1 MAP2K1 MAPK1 POU2F1 SNCA SNCB SUMO1 TP53 TRIP13 VRK1	21 interactors: AURKB CDK4 EXOSC10 FEZ1 IFI6 ITGA2B ITGB3 NBR1 NRIP1 PAX3 PLK2 PLK3 PRKDC PSEN1 PSEN2 PTK2 RAC3 TERT UBR5 WAS ZDHHC17
Entrez ID		1263	10519
HPRD ID		04222	03800
Ensembl ID		ENSG00000173846
Uniprot IDs		Q9H4B4	H6WJF3 Q99828
PDB IDs		4B6L	1DGU 1DGV 1XO5 1Y1A 2L4H 2L4I 2LM5
Enriched GO Terms of Interacting Partners?		Cell Cycle Mitotic Cell Cycle Organelle Organization Regulation Of Cellular Component Organization Regulation Of Organelle Organization Cellular Response To Stress Regulation Of Protein Metabolic Process Mitotic Nuclear Division Cell Cycle Process Regulation Of Protein Stability Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Process Double-strand Break Repair Regulation Of Golgi Inheritance Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Metabolic Process Cell Division Regulation Of Intracellular Transport Regulation Of Cellular Protein Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Metabolic Process Regulation Of Golgi Organization Golgi Inheritance Cell Aging Regulation Of Microtubule Polymerization Or Depolymerization Cellular Response To Growth Factor Stimulus Female Meiosis I DNA Repair Response To Growth Factor Positive Regulation Of Protein Serine/threonine Kinase Activity DNA Metabolic Process Regulation Of Protein Phosphorylation Developmental Process Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Early Endosome To Late Endosome Transport Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Aging Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Phosphorylation Peptidyl-serine Phosphorylation Replicative Senescence G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Histone-serine Phosphorylation	Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Apoptotic Process Response To Stimulus Regulation Of Cell Death Homotypic Cell-cell Adhesion Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Cell Communication Negative Regulation Of Cell Death Cell Activation Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Neuron Differentiation Generation Of Neurons Developmental Process Single Organismal Cell-cell Adhesion Signaling Neurogenesis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Stress Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Protein Binding Nervous System Development Cell Development Neuron Development Regulation Of Cellular Process Apoptotic Process Programmed Cell Death Regulation Of Cellular Component Organization Axon Guidance Organelle Organization Cell Death Movement Of Cell Or Subcellular Component Death Positive Regulation Of Cellular Metabolic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Multicellular Organismal Development Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Embryo Development Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Cell Cycle
Tagcloud ?		3a 5mum 5ng annotation correlating crosstalk doxo dusp5 etv7 fc fluoruracil inducer lamp3 log2 mcf7 microenvironment modify nfkappab ntn1 nutlin opposite proof qpcr repressed snai1 synergistically tnfalpha transcriptome unc5b	accelerated ask1 ca cytosolic depleting depolarization dysregulation efflux excessive folding homeostasis inactivated influx inositol insp3 insp3r ire1alpha mitochondrion otherwise perturbation posttranslational reservoir secretory sh superoxide sy5y traf2 triggers underlies
Tagcloud (Difference) ?		3a 5mum 5ng annotation correlating crosstalk doxo dusp5 etv7 fc fluoruracil inducer lamp3 log2 mcf7 microenvironment modify nfkappab ntn1 nutlin opposite proof qpcr repressed snai1 synergistically tnfalpha transcriptome unc5b	accelerated ask1 ca cytosolic depleting depolarization dysregulation efflux excessive folding homeostasis inactivated influx inositol insp3 insp3r ire1alpha mitochondrion otherwise perturbation posttranslational reservoir secretory sh superoxide sy5y traf2 triggers underlies
Tagcloud (Intersection) ?