PLK3 and VRK1

Number of citations of the paper that reports this interaction (PubMedID 19103756)
48

Data Source:
HPRD (in vivo, in vitro)

		PLK3	VRK1
Description		polo like kinase 3	VRK serine/threonine kinase 1
Image
GO Annotations	Cellular Component	Kinetochore Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Golgi Stack Centrosome Cytoskeleton Dendrite Neuronal Cell Body	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Stack Cytosol Cajal Body
	Molecular Function	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Nucleosomal DNA Binding Histone H3S10 Kinase Activity Histone Binding Histone H3T3 Kinase Activity Protein Serine Kinase Activity Histone H2AX Kinase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Response To Reactive Oxygen Species Protein Phosphorylation Apoptotic Process Response To Osmotic Stress DNA Damage Response Mitotic Spindle Organization Endomitotic Cell Cycle Response To Radiation Positive Regulation Of Autophagy Regulation Of Cell Cycle Process Regulation Of Cell Communication Regulation Of Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Cytoplasmic Microtubule Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Negative Regulation Of Apoptotic Process Mitotic G1/S Transition Checkpoint Signaling Positive Regulation Of Protein Catabolic Process Regulation Of Cell Division Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Golgi Disassembly Positive Regulation Of Intracellular Protein Transport Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Chaperone-mediated Autophagy	Chromatin Remodeling Protein Phosphorylation DNA Damage Response Mitotic Nuclear Membrane Disassembly Signal Transduction Cajal Body Organization Neuron Projection Development Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Cell Division Golgi Disassembly Positive Regulation Of Protein Localization To Chromatin Regulation Of Neuron Migration
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Regulation of TP53 Activity through Phosphorylation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation
Drugs		Fostamatinib
Diseases			Pontocerebellar hypoplasia
GWAS			Bone ultrasound measurement (velocity of sound) ( 28472463) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Cognitive function ( 24684796) Copper levels ( 26025379) Fractures (paediatric) ( 32742401) Metabolite levels ( 23823483) Neutrophil count ( 21507922) Night sleep phenotypes ( 27126917) Staphylococcus aureus infection ( 24847357)
Interacting Genes		23 interacting genes: AURKA BCL2L1 CDC25C CENPU CHEK2 CIB1 HIF1A LSM5 MAP2K1 MAPK1 MFF POU2F1 PPM1A RAD52 RNF141 RRM2 SLX4 SNCA SNCB TNS2 TP53 TRIP13 VRK1	9 interacting genes: H2BC21 H3C14 HIF1A NBN OGT PLK3 SRPK2 TP53 VHL
Entrez ID		1263	7443
HPRD ID		04222	03701
Ensembl ID		ENSG00000173846	ENSG00000100749
Uniprot IDs		Q9H4B4	A0A7P0T838 A0A7P0TB08 H0YJF7 Q99986
PDB IDs		4B6L	2KTY 2KUL 2LAV 2RSV 3OP5 5UKF 5UVF 6AC9 6BP0 6BRU 6BTW 6BU6 6CFM 6CMM 6CNX 6CQH 6CSW 6DD4 6NPN 6VXU 6VZH 7M10 7TAN 8F8Y 8V42
Enriched GO Terms of Interacting Partners?		Regulation Of Organelle Organization DNA Damage Response Neuron Apoptotic Process Double-strand Break Repair Cell Death Apoptotic Process Protein Kinase Binding Cellular Response To Stress Programmed Cell Death Positive Regulation Of Organelle Organization Regulation Of Reproductive Process Cellular Response To Gamma Radiation Identical Protein Binding Regulation Of Phosphorus Metabolic Process Response To Oxidative Stress Regulation Of Autophagy Nucleus Negative Regulation Of Apoptotic Process Regulation Of Golgi Inheritance Histone H3S10 Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Mitochondrion Organization Regulation Of Neuron Apoptotic Process Nucleoplasm Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Component Organization Leukocyte Apoptotic Process Regulation Of Cell Cycle Process Trachea Formation DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Protein Localization To Cell Periphery Response To Gamma Radiation Regulation Of Cellular Localization Response To Stress Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Small Molecule Metabolic Process DNA Repair Regulation Of Cellular Response To Stress Cell Cycle G2/M Phase Transition Positive Regulation Of MiRNA Transcription ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Cuprous Ion Binding Regulation Of Small Molecule Metabolic Process Regulation Of Programmed Cell Death	Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Nucleoplasm Neuroblast Proliferation Chromatin Organization Regulation Of Carbohydrate Catabolic Process P53 Binding Response To Stress Regulation Of Purine Nucleotide Metabolic Process Chromatin Remodeling R-loop Processing Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neural Precursor Cell Proliferation Signal Transduction By P53 Class Mediator Regulation Of Thymocyte Apoptotic Process Protein Heterodimerization Activity Negative Regulation Of RNA Metabolic Process Regulation Of Programmed Cell Death Regulation Of Autophagy Mitotic G1/S Transition Checkpoint Signaling Lactate Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Hypoxia Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Decreased Oxygen Levels Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction In Response To DNA Damage Regulation Of TOR Signaling Cellular Response To Oxygen Levels Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Intracellular Signal Transduction Replication Fork 14-3-3 Protein Binding Nucleus Negative Regulation Of Mitotic Cell Cycle Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Telomere Maintenance Negative Regulation Of Cell Cycle Phase Transition Regulation Of T Cell Apoptotic Process Protein-containing Complex Assembly Regulation Of Neuroblast Proliferation Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Neuron Apoptotic Process Chromosome Regulation Of Primary Metabolic Process
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