PLK3 and SLX4

Number of citations of the paper that reports this interaction (PubMedID 12548019)
0

Data Source:
BioGRID (two hybrid)

		PLK3	SLX4
Description		polo like kinase 3	SLX4 structure-specific endonuclease subunit
Image
GO Annotations	Cellular Component	Kinetochore Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Golgi Stack Centrosome Cytoskeleton Dendrite Neuronal Cell Body	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Slx1-Slx4 Complex Holliday Junction Resolvase Complex ERCC4-ERCC1 Complex
	Molecular Function	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	DNA Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Response To Reactive Oxygen Species Protein Phosphorylation Apoptotic Process Response To Osmotic Stress DNA Damage Response Mitotic Spindle Organization Endomitotic Cell Cycle Response To Radiation Positive Regulation Of Autophagy Regulation Of Cell Cycle Process Regulation Of Cell Communication Regulation Of Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Cytoplasmic Microtubule Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Negative Regulation Of Apoptotic Process Mitotic G1/S Transition Checkpoint Signaling Positive Regulation Of Protein Catabolic Process Regulation Of Cell Division Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Golgi Disassembly Positive Regulation Of Intracellular Protein Transport Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Chaperone-mediated Autophagy	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Nucleotide-excision Repair DNA Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Positive Regulation Of Telomere Maintenance Telomeric D-loop Disassembly Response To Intra-S DNA Damage Checkpoint Signaling T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Regulation of TP53 Activity through Phosphorylation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs		Fostamatinib
Diseases
GWAS			Type 2 diabetes ( 32499647)
Interacting Genes		23 interacting genes: AURKA BCL2L1 CDC25C CENPU CHEK2 CIB1 HIF1A LSM5 MAP2K1 MAPK1 MFF POU2F1 PPM1A RAD52 RNF141 RRM2 SLX4 SNCA SNCB TNS2 TP53 TRIP13 VRK1	9 interacting genes: APP EME1 ERCC4 ERG MUS81 PLK3 SLX1A UBC UBE2I
Entrez ID		1263	84464
HPRD ID		04222	12537
Ensembl ID		ENSG00000173846	ENSG00000188827
Uniprot IDs		Q9H4B4	Q8IY92
PDB IDs		4B6L	4M7C 4UYI 4ZOU 7BU5 7TUJ
Enriched GO Terms of Interacting Partners?		Regulation Of Organelle Organization DNA Damage Response Neuron Apoptotic Process Double-strand Break Repair Cell Death Apoptotic Process Protein Kinase Binding Cellular Response To Stress Programmed Cell Death Positive Regulation Of Organelle Organization Regulation Of Reproductive Process Cellular Response To Gamma Radiation Identical Protein Binding Regulation Of Phosphorus Metabolic Process Response To Oxidative Stress Regulation Of Autophagy Nucleus Negative Regulation Of Apoptotic Process Regulation Of Golgi Inheritance Histone H3S10 Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Mitochondrion Organization Regulation Of Neuron Apoptotic Process Nucleoplasm Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Component Organization Leukocyte Apoptotic Process Regulation Of Cell Cycle Process Trachea Formation DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Protein Localization To Cell Periphery Response To Gamma Radiation Regulation Of Cellular Localization Response To Stress Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Small Molecule Metabolic Process DNA Repair Regulation Of Cellular Response To Stress Cell Cycle G2/M Phase Transition Positive Regulation Of MiRNA Transcription ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Cuprous Ion Binding Regulation Of Small Molecule Metabolic Process Regulation Of Programmed Cell Death	Crossover Junction DNA Endonuclease Activity Resolution Of Meiotic Recombination Intermediates Telomere Maintenance Nuclease Activity Telomere Organization Response To Intra-S DNA Damage Checkpoint Signaling Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex Resolution Of Mitotic Recombination Intermediates Double-strand Break Repair Response To DNA Damage Checkpoint Signaling DNA Recombination Meiosis I Cell Cycle Process Endonuclease Activity Resolution Of DNA Recombination Intermediates Nucleoplasm Chromosome Organization DNA Damage Response Mitotic Intra-S DNA Damage Checkpoint Signaling Nucleus Nuclear Replication Fork Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Signal Transduction In Response To DNA Damage DNA Endonuclease Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Mitotic Cell Cycle DNA Repair Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Telomere Maintenance Replication Fork Processing Negative Regulation Of Cell Cycle Phase Transition Regulation Of Telomere Maintenance Via Telomere Lengthening DNA Binding Negative Regulation Of Cell Cycle Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Chaperone-mediated Autophagy DNA Metabolic Process SUMO Conjugating Enzyme Activity DNA Endonuclease Activity, Producing 3'-phosphomonoesters 3'-flap Endonuclease Activity Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?