PLK3 and TNS2

Number of citations of the paper that reports this interaction (PubMedID 12548019)
0

Data Source:
BioGRID (two hybrid)

		PLK3	TNS2
Description		polo like kinase 3	tensin 2
Image
GO Annotations	Cellular Component	Kinetochore Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Golgi Stack Centrosome Cytoskeleton Dendrite Neuronal Cell Body	Cytoplasm Plasma Membrane Focal Adhesion Membrane Anchoring Junction
	Molecular Function	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Zinc Ion Binding Lipid Binding Hydrolase Activity Kinase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Response To Reactive Oxygen Species Protein Phosphorylation Apoptotic Process Response To Osmotic Stress DNA Damage Response Mitotic Spindle Organization Endomitotic Cell Cycle Response To Radiation Positive Regulation Of Autophagy Regulation Of Cell Cycle Process Regulation Of Cell Communication Regulation Of Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Cytoplasmic Microtubule Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Negative Regulation Of Apoptotic Process Mitotic G1/S Transition Checkpoint Signaling Positive Regulation Of Protein Catabolic Process Regulation Of Cell Division Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Golgi Disassembly Positive Regulation Of Intracellular Protein Transport Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Chaperone-mediated Autophagy	Kidney Development Negative Regulation Of Cell Population Proliferation Response To Muscle Activity Cellular Homeostasis Collagen Metabolic Process Multicellular Organism Growth Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway Multicellular Organismal-level Homeostasis
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Regulation of TP53 Activity through Phosphorylation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Drugs		Fostamatinib
Diseases
GWAS
Interacting Genes		23 interacting genes: AURKA BCL2L1 CDC25C CENPU CHEK2 CIB1 HIF1A LSM5 MAP2K1 MAPK1 MFF POU2F1 PPM1A RAD52 RNF141 RRM2 SLX4 SNCA SNCB TNS2 TP53 TRIP13 VRK1	150 interacting genes: ADCK5 AMMECR1 AP1S2 AQP1 ARID5A ASB3 AXL BAHD1 BLZF1 BRCA1 C11orf87 C1orf94 CATSPER1 CCDC33 CNNM3 COX6B2 CPSF7 CRX CSNK1E CTSZ DCAF11 DCAF8 DDIT4L DLC1 DOK3 DZIP1 DZIP3 EGFR ENKD1 EPB41L4A EPDR1 EPS8L2 ERBB2 ERBB3 ERBB4 FABP7 FAM114A1 FAM228A FASLG FGF21 FGFR1 FOXO1 GATA1 GBA3 GFI1B HOXA1 HOXB9 HOXC8 HUWE1 ID2 IHO1 INO80B ITGB3 ITGB5 ITGB7 KCTD9 KIF1A KIT KPRP KRT76 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP13-1 KRTAP13-2 KRTAP23-1 KRTAP3-1 KRTAP4-4 KRTAP6-3 LASP1 LPXN LUZP4 MET MGAT5B MPEG1 MT2A MTDH MYBPHL MYH7B MYPOP NBPF19 NMU NOTCH2NLA NT5C NUBP2 OBSL1 OTX1 PATZ1 PER1 PHF1 PIN1 PKP1 PLB1 PLK3 PLSCR3 POLR1H POLR3F PRR22 RAMAC RBAK RBPMS REEP6 REL RFT1 RNF6 SDCCAG8 SERTAD2 SH2B3 SHFL SOCS7 SORBS3 SPATA12 SPRY2 SPRY4 SUSD2 SUV39H1 TBC1D16 TCP10L TEKT3 TEKT5 TENT5A TENT5B TFAP2D TLE5 TM4SF19 TRIM8 TSC1 TWSG1 USP54 WAC WDFY3 ZCCHC14 ZIM2 ZNF134 ZNF205 ZNF250 ZNF417 ZNF497 ZNF575 ZNF586 ZNF587 ZNF648 ZNF655 ZNF688 ZNF837
Entrez ID		1263	23371
HPRD ID		04222	16256
Ensembl ID		ENSG00000173846	ENSG00000111077
Uniprot IDs		Q9H4B4	Q63HR2
PDB IDs		4B6L	2DKQ 2KNO 2L6K 2LOZ 3HQC
Enriched GO Terms of Interacting Partners?		Regulation Of Organelle Organization DNA Damage Response Neuron Apoptotic Process Double-strand Break Repair Cell Death Apoptotic Process Protein Kinase Binding Cellular Response To Stress Programmed Cell Death Positive Regulation Of Organelle Organization Regulation Of Reproductive Process Cellular Response To Gamma Radiation Identical Protein Binding Regulation Of Phosphorus Metabolic Process Response To Oxidative Stress Regulation Of Autophagy Nucleus Negative Regulation Of Apoptotic Process Regulation Of Golgi Inheritance Histone H3S10 Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Mitochondrion Organization Regulation Of Neuron Apoptotic Process Nucleoplasm Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Component Organization Leukocyte Apoptotic Process Regulation Of Cell Cycle Process Trachea Formation DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Protein Localization To Cell Periphery Response To Gamma Radiation Regulation Of Cellular Localization Response To Stress Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Small Molecule Metabolic Process DNA Repair Regulation Of Cellular Response To Stress Cell Cycle G2/M Phase Transition Positive Regulation Of MiRNA Transcription ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Cuprous Ion Binding Regulation Of Small Molecule Metabolic Process Regulation Of Programmed Cell Death	Intermediate Filament Keratin Filament Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Receptor Complex Regulation Of RNA Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Gene Expression Nucleus Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Basal Plasma Membrane Ruffle Membrane Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process ERBB2 Signaling Pathway Cell-substrate Adhesion Salivary Gland Morphogenesis ERBB3:ERBB2 Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Negative Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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