PLK3 and SNCB

Number of citations of the paper that reports this interaction (PubMedID 19889641)
58

Data Source:
BioGRID (enzymatic study)

		PLK3	SNCB
Description		polo like kinase 3	synuclein beta
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Golgi Stack Centrosome Cytoskeleton Dendrite Neuronal Cell Body	Cytoplasm Cytosol Inclusion Body Neuronal Cell Body Axon Terminus Synapse
	Molecular Function	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Phospholipase Inhibitor Activity Calcium Ion Binding Protein Binding Transition Metal Ion Binding Cuprous Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Response To Reactive Oxygen Species Protein Phosphorylation Apoptotic Process Response To Osmotic Stress DNA Damage Response Mitotic Spindle Organization Endomitotic Cell Cycle Response To Radiation Positive Regulation Of Autophagy Regulation Of Cell Cycle Process Regulation Of Cell Communication Regulation Of Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Cytoplasmic Microtubule Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Negative Regulation Of Apoptotic Process Mitotic G1/S Transition Checkpoint Signaling Positive Regulation Of Protein Catabolic Process Regulation Of Cell Division Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Golgi Disassembly Positive Regulation Of Intracellular Protein Transport Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Chaperone-mediated Autophagy	Chemical Synaptic Transmission Dopamine Metabolic Process Negative Regulation Of Neuron Apoptotic Process Synaptic Vesicle Endocytosis Synapse Organization Neuron Apoptotic Process
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Regulation of TP53 Activity through Phosphorylation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	MTF1 activates gene expression
Drugs		Fostamatinib
Diseases			Lewy body dementia (LBD); Dementia with Lewy bodies (DLB)
GWAS
Interacting Genes		23 interacting genes: AURKA BCL2L1 CDC25C CENPU CHEK2 CIB1 HIF1A LSM5 MAP2K1 MAPK1 MFF POU2F1 PPM1A RAD52 RNF141 RRM2 SLX4 SNCA SNCB TNS2 TP53 TRIP13 VRK1	13 interacting genes: AKT1 APP CENPT GRK1 GRK5 GRK6 HSPA1A LNX1 MORN4 PLK1 PLK3 SEPTIN4 SNCA
Entrez ID		1263	6620
HPRD ID		04222	03980
Ensembl ID		ENSG00000173846	ENSG00000074317
Uniprot IDs		Q9H4B4	G4Y815 G4Y816 Q16143
PDB IDs		4B6L
Enriched GO Terms of Interacting Partners?		Regulation Of Organelle Organization DNA Damage Response Neuron Apoptotic Process Double-strand Break Repair Cell Death Apoptotic Process Protein Kinase Binding Cellular Response To Stress Programmed Cell Death Positive Regulation Of Organelle Organization Regulation Of Reproductive Process Cellular Response To Gamma Radiation Identical Protein Binding Regulation Of Phosphorus Metabolic Process Response To Oxidative Stress Regulation Of Autophagy Nucleus Negative Regulation Of Apoptotic Process Regulation Of Golgi Inheritance Histone H3S10 Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Mitochondrion Organization Regulation Of Neuron Apoptotic Process Nucleoplasm Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Component Organization Leukocyte Apoptotic Process Regulation Of Cell Cycle Process Trachea Formation DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Protein Localization To Cell Periphery Response To Gamma Radiation Regulation Of Cellular Localization Response To Stress Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Small Molecule Metabolic Process DNA Repair Regulation Of Cellular Response To Stress Cell Cycle G2/M Phase Transition Positive Regulation Of MiRNA Transcription ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Cuprous Ion Binding Regulation Of Small Molecule Metabolic Process Regulation Of Programmed Cell Death	G Protein-coupled Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Protein Catabolic Process Protein Serine/threonine Kinase Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Apoptotic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Programmed Cell Death Kinase Activity Beta-adrenergic Receptor Kinase Activity Protein Phosphorylation Regulation Of Proteolysis Phosphorylation Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Nucleotide Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Protein Localization Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Chaperone-mediated Autophagy ATP Binding Apoptotic Process Negative Regulation Of Apoptotic Process Postsynapse Phosphate-containing Compound Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Post-translational Protein Modification Programmed Cell Death Cell Death Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Cycle Inclusion Body Protein Autophosphorylation Transferase Activity Regulation Of Neurotransmitter Uptake Regulation Of Generation Of Precursor Metabolites And Energy Response To Oxidative Stress Cellular Response To Copper Ion Regulation Of Mitotic Spindle Assembly
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