PLK3 and SNCB

Number of citations of the paper that reports this interaction (PMID 19889641)
39

Data Source:
BioGRID (enzymatic study)

		PLK3	SNCB
Gene Name		polo-like kinase 3	synuclein, beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Golgi Stack Centrosome Dendrite Neuronal Cell Body	Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Inclusion Body Growth Cone Neuronal Cell Body Terminal Bouton
	Molecular Function	P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Phospholipase Inhibitor Activity Calcium Ion Binding Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Reactive Oxygen Species Protein Phosphorylation Apoptotic Process Response To Osmotic Stress Cellular Response To DNA Damage Stimulus Mitotic Cell Cycle Checkpoint Endomitotic Cell Cycle Response To Radiation Cytoplasmic Microtubule Organization Regulation Of Cytokinesis Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Mitotic G1/S Transition Checkpoint Regulation Of Cell Division Golgi Disassembly Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia	Synaptic Transmission Dopamine Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Synapse Organization
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: AURKA CDC25C CENPU CHEK2 CIB1 MAP2K1 MAPK1 POU2F1 SNCA SNCB SUMO1 TP53 TRIP13 VRK1	11 interactors: APP CENPT GRK1 GRK5 GRK6 HSPA1A LNX1 PLK1 PLK3 SEPT4 SNCA
Entrez ID		1263	6620
HPRD ID		04222	03980
Ensembl ID		ENSG00000173846	ENSG00000074317
Uniprot IDs		Q9H4B4	G4Y815 G4Y816 Q16143
PDB IDs		4B6L
Enriched GO Terms of Interacting Partners?		Cell Cycle Mitotic Cell Cycle Organelle Organization Regulation Of Cellular Component Organization Regulation Of Organelle Organization Cellular Response To Stress Regulation Of Protein Metabolic Process Mitotic Nuclear Division Cell Cycle Process Regulation Of Protein Stability Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Process Double-strand Break Repair Regulation Of Golgi Inheritance Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Metabolic Process Cell Division Regulation Of Intracellular Transport Regulation Of Cellular Protein Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Metabolic Process Regulation Of Golgi Organization Golgi Inheritance Cell Aging Regulation Of Microtubule Polymerization Or Depolymerization Cellular Response To Growth Factor Stimulus Female Meiosis I DNA Repair Response To Growth Factor Positive Regulation Of Protein Serine/threonine Kinase Activity DNA Metabolic Process Regulation Of Protein Phosphorylation Developmental Process Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Early Endosome To Late Endosome Transport Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Aging Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Phosphorylation Peptidyl-serine Phosphorylation Replicative Senescence G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Histone-serine Phosphorylation	Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Phosphorylation Positive Regulation Of Proteolysis Protein Phosphorylation Response To Oxidative Stress Regulation Of Protein Stability Posttranscriptional Regulation Of Gene Expression Apoptotic Process Programmed Cell Death Protein Destabilization Cell Death Death Regulation Of Signal Transduction Protein Metabolic Process Negative Regulation Of Signal Transduction Phosphate-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Cellular Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Processing Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Processing
Tagcloud ?		3a 5mum 5ng annotation correlating crosstalk doxo dusp5 etv7 fc fluoruracil inducer lamp3 log2 mcf7 microenvironment modify nfkappab ntn1 nutlin opposite proof qpcr repressed snai1 synergistically tnfalpha transcriptome unc5b	atp13a2 correction dj1 genotyped hapmap htra2 individually loci lrrk1 lrrk2 mapt midwest omi outbred park park2 pd pink1 rs2435200 siblings snca sncg snps spr tag uchl1 uncorrected usa variants
Tagcloud (Difference) ?		3a 5mum 5ng annotation correlating crosstalk doxo dusp5 etv7 fc fluoruracil inducer lamp3 log2 mcf7 microenvironment modify nfkappab ntn1 nutlin opposite proof qpcr repressed snai1 synergistically tnfalpha transcriptome unc5b	atp13a2 correction dj1 genotyped hapmap htra2 individually loci lrrk1 lrrk2 mapt midwest omi outbred park park2 pd pink1 rs2435200 siblings snca sncg snps spr tag uchl1 uncorrected usa variants
Tagcloud (Intersection) ?