PLK3 and LSM5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLK3	LSM5
Description		polo like kinase 3	LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
Image
GO Annotations	Cellular Component	Kinetochore Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Golgi Stack Centrosome Cytoskeleton Dendrite Neuronal Cell Body	Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Cytoplasm Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	RNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Response To Reactive Oxygen Species Protein Phosphorylation Apoptotic Process Response To Osmotic Stress DNA Damage Response Mitotic Spindle Organization Endomitotic Cell Cycle Response To Radiation Positive Regulation Of Autophagy Regulation Of Cell Cycle Process Regulation Of Cell Communication Regulation Of Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Cytoplasmic Microtubule Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Negative Regulation Of Apoptotic Process Mitotic G1/S Transition Checkpoint Signaling Positive Regulation Of Protein Catabolic Process Regulation Of Cell Division Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Golgi Disassembly Positive Regulation Of Intracellular Protein Transport Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Chaperone-mediated Autophagy	MRNA Splicing, Via Spliceosome MRNA Processing MRNA Catabolic Process RNA Splicing Response To Bacterium
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Regulation of TP53 Activity through Phosphorylation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs		Fostamatinib
Diseases
GWAS			Body mass index ( 26426971) Extremely high intelligence ( 29520040) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Morning person ( 30696823) Palmitic acid (16:0) levels ( 23362303) Smooth-surface caries ( 24556642)
Interacting Genes		23 interacting genes: AURKA BCL2L1 CDC25C CENPU CHEK2 CIB1 HIF1A LSM5 MAP2K1 MAPK1 MFF POU2F1 PPM1A RAD52 RNF141 RRM2 SLX4 SNCA SNCB TNS2 TP53 TRIP13 VRK1	23 interacting genes: CEBPA CPSF7 DDIT4L EXOSC5 HNRNPD LARP4 LSM1 LSM2 LSM3 LSM6 LSM7 LSM8 PLK3 PRPF38B PRRC2B QKI RBFOX2 SMN1 SNRPE SNRPF SPMIP10 TBPL1 TCL1B
Entrez ID		1263	23658
HPRD ID		04222	06285
Ensembl ID		ENSG00000173846	ENSG00000106355
Uniprot IDs		Q9H4B4	A0A090N8Y5 Q9Y4Y9
PDB IDs		4B6L	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		Regulation Of Organelle Organization DNA Damage Response Neuron Apoptotic Process Double-strand Break Repair Cell Death Apoptotic Process Protein Kinase Binding Cellular Response To Stress Programmed Cell Death Positive Regulation Of Organelle Organization Regulation Of Reproductive Process Cellular Response To Gamma Radiation Identical Protein Binding Regulation Of Phosphorus Metabolic Process Response To Oxidative Stress Regulation Of Autophagy Nucleus Negative Regulation Of Apoptotic Process Regulation Of Golgi Inheritance Histone H3S10 Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Mitochondrion Organization Regulation Of Neuron Apoptotic Process Nucleoplasm Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Component Organization Leukocyte Apoptotic Process Regulation Of Cell Cycle Process Trachea Formation DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Protein Localization To Cell Periphery Response To Gamma Radiation Regulation Of Cellular Localization Response To Stress Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Small Molecule Metabolic Process DNA Repair Regulation Of Cellular Response To Stress Cell Cycle G2/M Phase Transition Positive Regulation Of MiRNA Transcription ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Cuprous Ion Binding Regulation Of Small Molecule Metabolic Process Regulation Of Programmed Cell Death	MRNA Processing MRNA Metabolic Process RNA Processing RNA Splicing RNA Metabolic Process RNA Binding RNA Splicing, Via Transesterification Reactions U4/U6 X U5 Tri-snRNP Complex Lsm2-8 Complex U2-type Precatalytic Spliceosome U6 SnRNP Nucleic Acid Metabolic Process Lsm1-7-Pat1 Complex Precatalytic Spliceosome Spliceosomal Complex MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex Macromolecule Metabolic Process Catalytic Step 2 Spliceosome RNA Catabolic Process Spliceosomal SnRNP Assembly U6 SnRNA Binding MRNA Catabolic Process MRNA Binding Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex U12-type Spliceosomal Complex Nucleobase-containing Compound Catabolic Process P-body PICln-Sm Protein Complex Spliceosomal Complex Assembly U7 SnRNP 7-methylguanosine Cap Hypermethylation Nucleus U4 SnRNP Nucleoplasm Methylosome Protein-RNA Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process U1 SnRNP U5 SnRNP Negative Regulation Of Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Gene Expression U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome Nucleic Acid Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?