ERG28 and RAB27A

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ERG28	RAB27A
Description		ergosterol biosynthesis 28 homolog	RAB27A, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Transport Vesicle	Photoreceptor Outer Segment Extracellular Region Lysosome Endosome Late Endosome Golgi Apparatus Cytosol Membrane Apical Plasma Membrane Secretory Granule Dendrite Multivesicular Body Membrane Weibel-Palade Body Melanosome Membrane Specific Granule Lumen Melanosome Extracellular Exosome Exocytic Vesicle
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Steroid Metabolic Process Sterol Biosynthetic Process	Exocytosis Blood Coagulation Protein Secretion Positive Regulation Of Gene Expression Vesicle-mediated Transport Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Multivesicular Body Organization Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Pigmentation Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Pigment Granule Localization Pigment Granule Transport Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion
Pathways			Insulin processing Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Regulation of MITF-M-dependent genes involved in pigmentation
Drugs
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS			Fractional exhaled nitric oxide levels ( 25431337) Glioma ( 30714141)
Interacting Genes		127 interacting genes: ALDH2 ANXA1 ANXA7 AQP2 AQP3 AQP6 ARL13B BAIAP2 BCL2L13 BID BTBD2 CCDC106 CCL18 CD53 CD74 CDC42 CDK5RAP2 CELF3 CLDN5 CLDN7 CLN8 COX17 COXFA4L2 CRADD CREB1 CREB3 CREB3L1 CSTF2 CYB561 DYNLL1 EBP ELOVL4 ERBB2 ERBB3 ERBB4 ERGIC3 FAM174A FAM209A FAS FCGR2B FFAR2 FXR1 FXYD3 GADD45A GET1 GJB5 GPR152 GPR37L1 GPR42 GPX8 GSK3B HMGB1 HNRNPH3 HNRNPUL1 HSD17B11 HSPE1 HTR2C HYLS1 JAGN1 KCNJ6 KLHL20 LHFPL5 LMNA LSM2 LYPD5 MAPK8IP2 MGST3 MPHOSPH6 MRM1 MRPL38 MRPS12 MS4A3 MSMO1 MTERF3 MTNR1B MUC1 NAT9 NCR3LG1 NDUFA3 NR1H2 NSDHL NSF PAFAH1B3 PCDHA4 PDZK1IP1 PEX2 PFN1 PHYHIP PIGY POLE2 POLR2C POLR3F PPP1R8 PQBP1 PSCA RAB27A REEP4 RETREG3 RPS6KA6 S100A8 SAR1A SAT1 SEPHS1 SERPINB9 SGPL1 SLC10A6 SLC26A6 SLC34A2 SLC71A2 SNRPB SNRPG SSMEM1 STOM STX1A SULT1E1 TFG TK1 TLCD4 TM4SF19 TMEM106A TMEM222 TMEM31 TMPRSS2 TSC22D1 TTR ZFP64 ZNF24	28 interacting genes: ADRB2 APP CEP126 COPS6 EEF1A1 ERG28 EXPH5 GDF9 GDI1 GZMB LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16
Entrez ID		11161	5873
HPRD ID		05201	04845
Ensembl ID		ENSG00000133935	ENSG00000069974
Uniprot IDs		Q6FII3 Q86TW5 Q9UKR5	A2RU94 P51159
PDB IDs			6HUF 7OPP 7OPQ 7OPR 8P3G 8P3H 8P3I 8P3J 8P3K
Enriched GO Terms of Interacting Partners?		Protein Binding Membrane Identical Protein Binding Negative Regulation Of Apoptotic Process Renal Water Transport Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Polyol Transmembrane Transport Regulation Of Apoptotic Process Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Regulation Of Secretion Regulation Of Programmed Cell Death Endoplasmic Reticulum Membrane Regulation Of MAPK Cascade Fluid Transport Water Channel Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Viral Entry Into Host Cell Neuregulin Receptor Activity Regulation Of Transport Negative Regulation Of Hemopoiesis Negative Regulation Of Secretion Apolipoprotein A-I Receptor Binding Regulation Of Protein-containing Complex Assembly Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Peptide Secretion Apical Plasma Membrane Positive Regulation Of Transport	Small GTPase Binding Intracellular Transport Establishment Of Localization In Cell Secretion By Cell Exocytosis Intracellular Protein Transport Cellular Localization Protein Transport Exocytic Vesicle Vesicle-mediated Transport Neurexin Family Protein Binding Secretion Establishment Of Protein Localization Intracellular Protein Localization Regulation Of Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Exocytosis Modulation Of Excitatory Postsynaptic Potential Regulation Of Secretion By Cell Regulation Of Secretion Regulation Of Regulated Secretory Pathway Regulation Of Vesicle-mediated Transport Positive Regulation Of Secretion By Cell Vesicle Docking Involved In Exocytosis Melanosome Positive Regulation Of Secretion Synaptic Vesicle Docking Positive Regulation Of Regulated Secretory Pathway Regulation Of Nervous System Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Priming Vesicle Docking Regulation Of Transport Signal Release Organelle Localization By Membrane Tethering Organelle Localization Myosin Binding Positive Regulation Of Establishment Of Protein Localization Membrane Docking Regulation Of Hormone Levels Neurotransmitter Transport Synaptic Vesicle Exocytosis Calcium-ion Regulated Exocytosis Regulated Exocytosis Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Transport Protein Localization To Extracellular Region
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