RAB27A and MYRIP

Number of citations of the paper that reports this interaction (PMID 12590134)
10

Data Source:
HPRD (in vitro, in vivo)

		RAB27A	MYRIP
Gene Name		RAB27A, member RAS oncogene family	myosin VIIA and Rab interacting protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Lysosome Late Endosome Golgi Apparatus Apical Plasma Membrane Secretory Granule Dendrite Secretory Granule Membrane Multivesicular Body Membrane Melanosome Extracellular Vesicular Exosome Exocytic Vesicle	Exocyst Photoreceptor Outer Segment Actin Cytoskeleton Transport Vesicle Dense Core Granule Melanosome Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding	Actin Binding Protein Binding Zinc Ion Binding Rab GTPase Binding Protein Kinase A Binding
	Biological Process	Protein Targeting Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Blood Coagulation Protein Secretion Positive Regulation Of Gene Expression Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Rab Protein Signal Transduction Multivesicular Body Organization Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Cellular Protein Metabolic Process Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion	Intracellular Protein Transport Positive Regulation Of Insulin Secretion
Pathways		Peptide hormone metabolism Insulin processing
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 23007406) Information processing speed ( 21130836) Sleep duration ( 17903308)
Protein-Protein Interactions		28 interactors: ADRB2 APP C14orf1 COPS6 EEF1A1 EXPH5 GDF9 GDI1 GZMB KIAA1377 LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16	3 interactors: C1orf216 MYO7A RAB27A
Entrez ID		5873	25924
HPRD ID		04845	14796
Ensembl ID		ENSG00000069974	ENSG00000170011
Uniprot IDs		A2RU94 P51159	Q8NFW9
PDB IDs
Enriched GO Terms of Interacting Partners?		Exocytosis Secretion By Cell Intracellular Transport Secretion Cellular Protein Localization Establishment Of Localization In Cell Cellular Localization Protein Transport Intracellular Protein Transport Establishment Of Protein Localization Protein Localization Vesicle-mediated Transport Regulation Of Secretion Regulation Of Cellular Localization Regulation Of Exocytosis Positive Regulation Of Secretion Transport Positive Regulation Of Exocytosis Positive Regulation Of Transport Regulation Of Vesicle-mediated Transport Regulation Of Establishment Of Protein Localization Multivesicular Body Sorting Pathway Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Membrane Potential Calcium Ion-dependent Exocytosis Regulation Of Protein Localization Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Protein Transport Positive Regulation Of Protein Secretion Regulation Of Protein Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Vesicle Localization Regulation Of Postsynaptic Membrane Potential Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Hormone Secretion Neurotransmitter Secretion Regulation Of Signaling Membrane Depolarization Glutamate Secretion Positive Regulation Of Protein Transport Regulation Of Neurotransmitter Levels Membrane Hyperpolarization Melanocyte Differentiation Neurotransmitter Transport Melanosome Localization Visual Perception Sensory Perception Of Light Stimulus Insulin Secretion Organelle Localization	Pigment Granule Transport Cellular Pigmentation Pigmentation Establishment Of Vesicle Localization Vesicle Localization Positive Regulation Of Constitutive Secretory Pathway Complement-dependent Cytotoxicity Multivesicular Body Organization Cytotoxic T Cell Degranulation Establishment Of Organelle Localization Multivesicular Body Sorting Pathway Exosomal Secretion Organelle Localization Natural Killer Cell Degranulation Epithelial Cell Differentiation Equilibrioception T Cell Mediated Cytotoxicity Post-embryonic Organ Morphogenesis Auditory Receptor Cell Stereocilium Organization Auditory Receptor Cell Morphogenesis Phagolysosome Assembly Auditory Receptor Cell Development Intracellular Protein Transport Natural Killer Cell Activation Involved In Immune Response Inner Ear Receptor Stereocilium Organization Positive Regulation Of Regulated Secretory Pathway Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Epithelium Development Leukocyte Mediated Cytotoxicity T Cell Mediated Immunity Endosome Organization Melanosome Transport Auditory Receptor Cell Differentiation Establishment Of Melanosome Localization Melanocyte Differentiation Leukocyte Degranulation Melanosome Localization Hair Cell Differentiation Eye Photoreceptor Cell Development Regulation Of Regulated Secretory Pathway Cellular Protein Localization Inner Ear Receptor Cell Development Protein Transport Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Neuroepithelial Cell Differentiation Phagosome Maturation Vesicle-mediated Transport Establishment Of Protein Localization Photoreceptor Cell Development
Tagcloud ?		adenocarcinoma aggressive benign cancerous carcinomas deadly ductal exosome gtpases hypothesized immunohistochemistry implicated invasion invasive malignancies member microarray microenvironment modulating pancreatic pdac regulating represent secretion tissues tp53 trafficking vesicle
Tagcloud (Difference) ?		adenocarcinoma aggressive benign cancerous carcinomas deadly ductal exosome gtpases hypothesized immunohistochemistry implicated invasion invasive malignancies member microarray microenvironment modulating pancreatic pdac regulating represent secretion tissues tp53 trafficking vesicle
Tagcloud (Intersection) ?