RAB27A and MYRIP

Number of citations of the paper that reports this interaction (PubMedID 12590134)
0

Data Source:
HPRD (in vitro, in vivo)

		RAB27A	MYRIP
Description		RAB27A, member RAS oncogene family	myosin VIIA and Rab interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Region Lysosome Endosome Late Endosome Golgi Apparatus Cytosol Membrane Apical Plasma Membrane Secretory Granule Dendrite Multivesicular Body Membrane Weibel-Palade Body Melanosome Membrane Specific Granule Lumen Melanosome Extracellular Exosome Exocytic Vesicle	Exocyst Photoreceptor Outer Segment Cytoplasm Cytosol Actin Cytoskeleton Transport Vesicle Cortical Actin Cytoskeleton Dense Core Granule Cytoplasmic Vesicle Melanosome Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Myosin V Binding	Actin Binding Protein Binding Zinc Ion Binding Myosin Binding Small GTPase Binding Metal Ion Binding Protein Kinase A Binding
	Biological Process	Exocytosis Blood Coagulation Protein Secretion Positive Regulation Of Gene Expression Vesicle-mediated Transport Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Multivesicular Body Organization Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Pigmentation Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Pigment Granule Localization Pigment Granule Transport Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion	Intracellular Protein Transport Positive Regulation Of Insulin Secretion
Pathways		Insulin processing Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Regulation of MITF-M-dependent genes involved in pigmentation	Insulin processing Regulation of MITF-M-dependent genes involved in pigmentation
Drugs
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Fractional exhaled nitric oxide levels ( 25431337) Glioma ( 30714141)	Acute lymphoblastic leukemia (childhood) ( 23007406) Information processing speed ( 21130836) Rapid automised naming of letters ( 30741946) Sleep-related phenotypes ( 17903308) Whole brain grey matter density ( 31530798)
Interacting Genes		28 interacting genes: ADRB2 APP CEP126 COPS6 EEF1A1 ERG28 EXPH5 GDF9 GDI1 GZMB LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16	6 interacting genes: C1orf216 MYO7A OIP5 RAB27A RAB27B VPS26C
Entrez ID		5873	25924
HPRD ID		04845	14796
Ensembl ID		ENSG00000069974	ENSG00000170011
Uniprot IDs		A2RU94 P51159	Q8NFW9
PDB IDs		6HUF 7OPP 7OPQ 7OPR 8P3G 8P3H 8P3I 8P3J 8P3K
Enriched GO Terms of Interacting Partners?		Small GTPase Binding Intracellular Transport Establishment Of Localization In Cell Secretion By Cell Exocytosis Intracellular Protein Transport Cellular Localization Protein Transport Exocytic Vesicle Vesicle-mediated Transport Neurexin Family Protein Binding Secretion Establishment Of Protein Localization Intracellular Protein Localization Regulation Of Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Exocytosis Modulation Of Excitatory Postsynaptic Potential Regulation Of Secretion By Cell Regulation Of Secretion Regulation Of Regulated Secretory Pathway Regulation Of Vesicle-mediated Transport Positive Regulation Of Secretion By Cell Vesicle Docking Involved In Exocytosis Melanosome Positive Regulation Of Secretion Synaptic Vesicle Docking Positive Regulation Of Regulated Secretory Pathway Regulation Of Nervous System Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Priming Vesicle Docking Regulation Of Transport Signal Release Organelle Localization By Membrane Tethering Organelle Localization Myosin Binding Positive Regulation Of Establishment Of Protein Localization Membrane Docking Regulation Of Hormone Levels Neurotransmitter Transport Synaptic Vesicle Exocytosis Calcium-ion Regulated Exocytosis Regulated Exocytosis Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Transport Protein Localization To Extracellular Region	Melanosome Pigment Granule Localization Protein Domain Specific Binding Pigment Granule Transport Multivesicular Body Membrane Exocytic Vesicle Myosin V Binding Multivesicular Body Sorting Pathway Apical Plasma Membrane Vesicle-mediated Transport Upper Tip-link Density Protein Transport Myosin VII Complex Photoreceptor Outer Segment GDP Binding Positive Regulation Of Exocytosis Cytotoxic T Cell Degranulation Positive Regulation Of Constitutive Secretory Pathway G Protein Activity Establishment Of Protein Localization Intracellular Protein Transport Establishment Of Vesicle Localization Secretory Granule Vesicle Localization Establishment Of Localization In Cell Complement-dependent Cytotoxicity Pericentric Heterochromatin Organization CENP-A Recruiting Complex Late Endosome Phagolysosome Assembly Stereocilium Base Intracellular Protein Localization Exosomal Secretion Endosome Equilibrioception Regulation Of Exocytosis Weibel-Palade Body Exocytosis Platelet Dense Granule Membrane Natural Killer Cell Degranulation Photoreceptor Cell Cilium Anterograde Axonal Protein Transport Establishment Of Organelle Localization CENP-A Containing Chromatin Assembly Chromocenter Positive Regulation Of Secretion By Cell Protein Transport Along Microtubule Vesicle Organization GTPase Activity Positive Regulation Of Secretion
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