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RAB27A and GZMB
Number of citations of the paper that reports this interaction (PubMedID
11266473
)
20
Data Source:
HPRD
(in vivo)
RAB27A
GZMB
Description
RAB27A, member RAS oncogene family
granzyme B
Image
GO Annotations
Cellular Component
Photoreceptor Outer Segment
Extracellular Region
Lysosome
Endosome
Late Endosome
Golgi Apparatus
Cytosol
Membrane
Apical Plasma Membrane
Secretory Granule
Dendrite
Multivesicular Body Membrane
Weibel-Palade Body
Melanosome Membrane
Specific Granule Lumen
Melanosome
Extracellular Exosome
Exocytic Vesicle
Immunological Synapse
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Lysosome
Cytosol
Membrane
Cytolytic Granule
Cytolytic Granule Lumen
Molecular Function
Nucleotide Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
Hydrolase Activity
GDP Binding
Protein Domain Specific Binding
Myosin V Binding
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Hydrolase Activity
Biological Process
Exocytosis
Blood Coagulation
Protein Secretion
Positive Regulation Of Gene Expression
Vesicle-mediated Transport
Antigen Processing And Presentation
Melanocyte Differentiation
Melanosome Localization
Melanosome Transport
Multivesicular Body Organization
Cytotoxic T Cell Degranulation
Natural Killer Cell Degranulation
Pigmentation
Positive Regulation Of Exocytosis
Synaptic Vesicle Transport
Positive Regulation Of Phagocytosis
Pigment Granule Localization
Pigment Granule Transport
Multivesicular Body Sorting Pathway
Complement-dependent Cytotoxicity
Positive Regulation Of Regulated Secretory Pathway
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Positive Regulation Of Constitutive Secretory Pathway
Exosomal Secretion
Plasma Membrane Repair
Positive Regulation Of Immune Response To Tumor Cell
Proteolysis
Apoptotic Process
Protein Secretion
Negative Regulation Of Translation
Killing Of Cells Of Another Organism
Natural Killer Cell Mediated Cytotoxicity
Ceramide Biosynthetic Process
Proteolysis Involved In Protein Catabolic Process
Protein Maturation
Pyroptotic Inflammatory Response
Granzyme-mediated Programmed Cell Death Signaling Pathway
Pyroptotic Cell Death
Positive Regulation Of Establishment Of Protein Localization To Mitochondrion
Pathways
Insulin processing
Neutrophil degranulation
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Regulation of MITF-M-dependent genes involved in pigmentation
NOTCH2 intracellular domain regulates transcription
Pyroptosis
Activation, myristolyation of BID and translocation to mitochondria
Nuclear events stimulated by ALK signaling in cancer
Drugs
Diseases
Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS
Fractional exhaled nitric oxide levels (
25431337
)
Glioma (
30714141
)
Blood protein levels (
30072576
)
Emphysema annual change measurement in smokers (adjusted lung density) (
31324189
)
Interleukin-10 levels in non-alcoholic fatty liver disease x mastiha supplementation interaction (
34025683
)
Vitiligo (
20410501
27723757
)
Interacting Genes
28 interacting genes:
ADRB2
APP
CEP126
COPS6
EEF1A1
ERG28
EXPH5
GDF9
GDI1
GZMB
LRIF1
MLPH
MYO5A
MYRIP
RABGGTB
RBM48
RIMS1
RIMS2
RPH3A
RPH3AL
STX1A
SYTL1
SYTL2
SYTL3
SYTL4
SYTL5
UNC13D
ZBTB16
26 interacting genes:
BID
CASP3
CASP7
CASP8
CASP9
CD2AP
CHRM3
DFFA
GRIA3
IGF2R
LMNA
LMNB1
PARP1
PRF1
PRKDC
PTGES3
PTK2
RAB27A
SERPINB9
SRGN
TUBA1A
UBE4A
UBE4B
XRCC4
XRCC5
XRCC6
Entrez ID
5873
3002
HPRD ID
04845
00476
Ensembl ID
ENSG00000069974
ENSG00000100453
Uniprot IDs
A2RU94
P51159
J3KQ52
P10144
Q67BC3
Q6XGZ4
PDB IDs
6HUF
7OPP
7OPQ
7OPR
8P3G
8P3H
8P3I
8P3J
8P3K
1FQ3
1IAU
Enriched GO Terms of Interacting Partners
?
Small GTPase Binding
Intracellular Transport
Establishment Of Localization In Cell
Secretion By Cell
Exocytosis
Intracellular Protein Transport
Cellular Localization
Protein Transport
Exocytic Vesicle
Vesicle-mediated Transport
Neurexin Family Protein Binding
Secretion
Establishment Of Protein Localization
Intracellular Protein Localization
Regulation Of Exocytosis
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of Exocytosis
Modulation Of Excitatory Postsynaptic Potential
Regulation Of Secretion By Cell
Regulation Of Secretion
Regulation Of Regulated Secretory Pathway
Regulation Of Vesicle-mediated Transport
Positive Regulation Of Secretion By Cell
Vesicle Docking Involved In Exocytosis
Melanosome
Positive Regulation Of Secretion
Synaptic Vesicle Docking
Positive Regulation Of Regulated Secretory Pathway
Regulation Of Nervous System Process
Regulation Of Establishment Of Protein Localization
Positive Regulation Of Calcium Ion-dependent Exocytosis
Synaptic Vesicle Priming
Vesicle Docking
Regulation Of Transport
Signal Release
Organelle Localization By Membrane Tethering
Organelle Localization
Myosin Binding
Positive Regulation Of Establishment Of Protein Localization
Membrane Docking
Regulation Of Hormone Levels
Neurotransmitter Transport
Synaptic Vesicle Exocytosis
Calcium-ion Regulated Exocytosis
Regulated Exocytosis
Spontaneous Neurotransmitter Secretion
Positive Regulation Of Inhibitory Postsynaptic Potential
Regulation Of Calcium Ion-dependent Exocytosis
Positive Regulation Of Transport
Protein Localization To Extracellular Region
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Nonhomologous End Joining Complex
Response To Radiation
Positive Regulation Of Programmed Cell Death
Programmed Cell Death
Cell Death
Regulation Of Programmed Cell Death
DNA-dependent Protein Kinase Complex
Apoptotic Process
Regulation Of Apoptotic Process
Response To Anesthetic
Response To Ionizing Radiation
Cellular Response To Stress
Protein Processing
Protein Maturation
Response To Cobalt Ion
Telomere Maintenance
Pyroptotic Inflammatory Response
Fibroblast Apoptotic Process
Protein-DNA Complex
Neuron Apoptotic Process
Granzyme-mediated Programmed Cell Death Signaling Pathway
Leukocyte Apoptotic Process
Positive Regulation Of Apoptotic Process
Response To Gamma Radiation
Protein-containing Complex
Telomere Organization
Regulation Of Neuron Apoptotic Process
Death Receptor Binding
Double-strand Break Repair Via Nonhomologous End Joining
Structural Constituent Of Nuclear Lamina
Response To Stress
Protein Poly-ADP-ribosylation
Cysteine-type Endopeptidase Activity
Response To UV
Positive Regulation Of Neuron Apoptotic Process
Enzyme Activator Activity
Macromolecule Metabolic Process
DNA End Binding
Ku70:Ku80 Complex
Small-subunit Processome Assembly
Chromosome, Telomeric Region
Execution Phase Of Apoptosis
Response To Light Stimulus
Regulation Of Immune Response
Apoptotic Signaling Pathway
Response To Metal Ion
Immune System Process
Response To X-ray
Regulation Of Immune System Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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