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RAB27A and MLPH
Number of citations of the paper that reports this interaction (PubMedID
11856727
)
0
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
RAB27A
MLPH
Description
RAB27A, member RAS oncogene family
melanophilin
Image
No pdb structure
GO Annotations
Cellular Component
Photoreceptor Outer Segment
Extracellular Region
Lysosome
Endosome
Late Endosome
Golgi Apparatus
Cytosol
Membrane
Apical Plasma Membrane
Secretory Granule
Dendrite
Multivesicular Body Membrane
Weibel-Palade Body
Melanosome Membrane
Specific Granule Lumen
Melanosome
Extracellular Exosome
Exocytic Vesicle
Cytoplasm
Cytosol
Dendrite
Cortical Actin Cytoskeleton
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Nucleotide Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
Hydrolase Activity
GDP Binding
Protein Domain Specific Binding
Myosin V Binding
Actin Binding
Protein Binding
Zinc Ion Binding
Myosin Binding
Protein-macromolecule Adaptor Activity
Small GTPase Binding
Metal Ion Binding
Biological Process
Exocytosis
Blood Coagulation
Protein Secretion
Positive Regulation Of Gene Expression
Vesicle-mediated Transport
Antigen Processing And Presentation
Melanocyte Differentiation
Melanosome Localization
Melanosome Transport
Multivesicular Body Organization
Cytotoxic T Cell Degranulation
Natural Killer Cell Degranulation
Pigmentation
Positive Regulation Of Exocytosis
Synaptic Vesicle Transport
Positive Regulation Of Phagocytosis
Pigment Granule Localization
Pigment Granule Transport
Multivesicular Body Sorting Pathway
Complement-dependent Cytotoxicity
Positive Regulation Of Regulated Secretory Pathway
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Positive Regulation Of Constitutive Secretory Pathway
Exosomal Secretion
Intracellular Protein Transport
Melanosome Transport
Pathways
Insulin processing
Neutrophil degranulation
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Regulation of MITF-M-dependent genes involved in pigmentation
Regulation of MITF-M-dependent genes involved in pigmentation
Drugs
Diseases
Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS
Fractional exhaled nitric oxide levels (
25431337
)
Glioma (
30714141
)
Central corneal thickness (
32528159
)
Heel bone mineral density (
28869591
30598549
)
Height (
33713608
)
Intraocular pressure (
29617998
)
Prostate cancer (
21743057
)
Interacting Genes
28 interacting genes:
ADRB2
APP
CEP126
COPS6
EEF1A1
ERG28
EXPH5
GDF9
GDI1
GZMB
LRIF1
MLPH
MYO5A
MYRIP
RABGGTB
RBM48
RIMS1
RIMS2
RPH3A
RPH3AL
STX1A
SYTL1
SYTL2
SYTL3
SYTL4
SYTL5
UNC13D
ZBTB16
7 interacting genes:
BLOC1S6
C1orf216
MTDH
MYO5A
RAB27A
RAB27B
RECK
Entrez ID
5873
79083
HPRD ID
04845
09409
Ensembl ID
ENSG00000069974
ENSG00000115648
Uniprot IDs
A2RU94
P51159
Q9BV36
PDB IDs
6HUF
7OPP
7OPQ
7OPR
8P3G
8P3H
8P3I
8P3J
8P3K
Enriched GO Terms of Interacting Partners
?
Small GTPase Binding
Intracellular Transport
Establishment Of Localization In Cell
Secretion By Cell
Exocytosis
Intracellular Protein Transport
Cellular Localization
Protein Transport
Exocytic Vesicle
Vesicle-mediated Transport
Neurexin Family Protein Binding
Secretion
Establishment Of Protein Localization
Intracellular Protein Localization
Regulation Of Exocytosis
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of Exocytosis
Modulation Of Excitatory Postsynaptic Potential
Regulation Of Secretion By Cell
Regulation Of Secretion
Regulation Of Regulated Secretory Pathway
Regulation Of Vesicle-mediated Transport
Positive Regulation Of Secretion By Cell
Vesicle Docking Involved In Exocytosis
Melanosome
Positive Regulation Of Secretion
Synaptic Vesicle Docking
Positive Regulation Of Regulated Secretory Pathway
Regulation Of Nervous System Process
Regulation Of Establishment Of Protein Localization
Positive Regulation Of Calcium Ion-dependent Exocytosis
Synaptic Vesicle Priming
Vesicle Docking
Regulation Of Transport
Signal Release
Organelle Localization By Membrane Tethering
Organelle Localization
Myosin Binding
Positive Regulation Of Establishment Of Protein Localization
Membrane Docking
Regulation Of Hormone Levels
Neurotransmitter Transport
Synaptic Vesicle Exocytosis
Calcium-ion Regulated Exocytosis
Regulated Exocytosis
Spontaneous Neurotransmitter Secretion
Positive Regulation Of Inhibitory Postsynaptic Potential
Regulation Of Calcium Ion-dependent Exocytosis
Positive Regulation Of Transport
Protein Localization To Extracellular Region
Pigment Granule Localization
Establishment Of Melanosome Localization
Melanosome Localization
Melanosome Transport
Pigment Granule Transport
Melanosome
Establishment Of Vesicle Localization
Vesicle Localization
Myosin V Binding
Late Endosome
Melanocyte Differentiation
Pigment Cell Differentiation
Exocytic Vesicle
Cytoskeleton-dependent Intracellular Transport
Multivesicular Body Membrane
Synaptic Vesicle Transport
Establishment Of Organelle Localization
Anterograde Axonal Transport
Pigmentation
Multivesicular Body Sorting Pathway
Vesicle Cytoskeletal Trafficking
Axon Cytoplasm
Axonal Transport
Apical Plasma Membrane
Secretion By Cell
GDP Binding
Cytotoxic T Cell Degranulation
Positive Regulation Of Constitutive Secretory Pathway
G Protein Activity
Bradykinin Biosynthetic Process
Circadian Sleep/wake Cycle
Protein Transport
Axo-dendritic Transport
Positive Regulation Of Exocytosis
Organelle Localization
Blood Coagulation
Secretory Granule
Ruffle
Coagulation
Secretion
Hemostasis
Establishment Of Protein Localization
Protein Localization To Extracellular Region
Establishment Of Protein Localization To Extracellular Region
Protein Secretion
Complement-dependent Cytotoxicity
Regulation Of Establishment Of Blood-brain Barrier
Intracellular Nitric Oxide Homeostasis
Exosomal Secretion
Establishment Of Localization In Cell
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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